psychomimetic
Bluelighter
That's interesting. I can understand this would apply to morphine, but heroin has the extra acetyl groups that are amazingly lipophilic, which would make snorting (in theory) just as good as rectal with quicker onset (assuming most is NOT swallowed by drip). Well anyway, here's the article, the intranasal and rectal analysis is on page 5...
http://www.bentham.org/ccp/samples/ccp1-1/Rook.pdf
Routes of Administration: "Considerable peak plasma concentrations of heroin and a fast absorption rate were established after intranasal application (snorting) or inhalation in the lungs... because of its lipophilicity and low ionisation grade at physiological pH, heroin is rapidly absorbed through the mucous membranes... the first pass effecdt by the liver is avoided in these routes of administration."
"When heroin was administered orally or rectally, no heroin or 6-monoacetylmorphine could be detected in plasma... Probably hydrolysis of heroin into morphine occurred under the alkaline condition of the duodenum and colon before absorption. Moreover, heroin could be subject of the first pass effect by esterases in the liver."
Next is some ambiguity regarding what was said previously about rectal absorption...
"The first pass mechanism by the liver is avoided to a high extent after application of a heroin suppository, resulting in a lower M3G/morphine ration after rectal administration than after oral administration of heroin. Scores on euphoria were significantly higher after rectal application than after an equal oral heroin dose."
The inconsistency between the second and third quoted parts confuses me about what is actually being said. Can anyone understand this?
That's pretty confusing indeed. In my experience, when plugging I use a slightly higher dose then IV. I've only snorted heroin once, and I used a bit more then I would plug, but I can't really compare because I never plugged any of that stuff so I don't know if it was just lower quality or what. Seeing as I live in Tx, I've only seen powder once and thus have only snorted heroin once, the first time I did it. Good times in the middle school bathroom....