if a drug gets out of you system faster will your tolerance go down faster?

[nothing]

like if you drink a lot of water and stuff does it help your tolerance go down too?

 

[Unknown]

from my personal experience with opioids, no. You have to say off them for a peroid of time. The drug itself isn't creating the tolerance. Its the chemical reaction in the brain and the amount of receptors that determine tolerance. I would think this applies to other class of drugs as well.

 

[brutus]

Even if you do abstain from drugs from a long period of time, your tolerance will come back a lot quicker than you developed it. I spent almost 6 months clean from opiates and within a week or so of taken hydrocodone, I was taking 240 mg.

 

[Unknown]

Even if you do abstain from drugs from a long period of time, your tolerance will come back a lot quicker than you developed it. I spent almost 6 months clean from opiates and within a week or so of taken hydrocodone, I was taking 240 mg.

Yeah, thats what sucks about any opiate. I havn't used them that heavily or that long, so I can quit for a week and be back at baseline for a looooong time. To the OP, just be careful. wiggi is a good example of a permanent high tolerance.

 

[Newmoonrecord]

OT: is the shorter half life of a drug mean that there will be a shorter withdrawal?

 

[brutus]

^ I wouldn't say my tolerance was all that high, there are people with a much higher tolerance, I'm on bupe now though so I really don't mess with opiates, unless it's something worthwhile like hydromorphone.

 

[Unknown]

OT: is the shorter half life of a drug mean that there will be a shorter withdrawal?

I would say the half life doesn't play a big roll in withdrawal. Its more of the amount of tolerance you have (physically and mentally), the amount you take and for how long, and what class of drug it is / MOA. If half life were the determining factor, people who smoke pot would withdrawal worse than people who smoke crack.

 

[bingey]

OT: is the shorter half life of a drug mean that there will be a shorter withdrawal?

As a rule of thumb i'd say yes , but doesn't go for everything for instance obviously methadone and bupe withdrawals will be longer than morphine or heroin withdrawals on the other hand codeine which only lasts about 4 hours has the same lenght of withdrawals as morphine (maybe the pro druh thing but i think it was proven it actually has another mechanism which makes it work)

 

[Unknown]

As a rule of thumb i'd say yes , but doesn't go for everything for instance obviously methadone and bupe withdrawals will be longer than morphine or heroin withdrawals.........

Im not trying to be rude at all, but thats statements an oxymoron. You said yes, but not for everything. Its either half-lifes and withdrawals have a correlation with each other or not. A half-life of a drug dictates how long it is active. This does not determine peak plasma levels or traces levels in the body. The withdrawal is brought on by the lack of a substance that the body is dependent on. This has nothing to do with the half-life of the drug. When the half-life of the drug has been exceeded, one MIGHT go into some sort or withdrawal, but to say theres a correlation between half-life and withdrawal is plain silly.

 

[bingey]

^
why are methadone withdrawals 3x times as long as dope withdrawals?

I mean the longer something affects you the longer the opposite reaction will be , its a bit like newton really.

I dont think its a coincidence and there is definately a correlation , oh and i said as a rule of thumb just to cover my ass , in fact i think it always applies

oh and half life means the time it takes for half of the drug to leave your body


ps I wonder if the way the drug is administrated effects WD too , like intravenous use giving shorter but more intense withdrawals could definately see that coming however now im just ranting

 

[Unknown]

^
why are methadone withdrawals 3x times as long as dope withdrawals?

I didn't want to get technical, but here we go: Methadones withdrawal aren't a direct affect from the half-life. Methadone is a full mu agonist. The withdrawals are caused from the potency of the mu agonist. Methadone is one of the strongest full mu agonist out there. I dont know off the top of my head if methadone is a K opoid agonist? Reguardless, the mu and the K opoid receptors have very strong physical dependance characteristics to it. Thats why people feel like shit when they get off opiates.

I mean the longer something affects you the longer the opposite reaction will be , its a bit like newton really.

I thought so at one time too, but I learned the brain is quite a unique one.

I dont think its a coincidence and there is definately a correlation , oh and i said as a rule of thumb just to cover my ass , in fact i think it always applies

Not always, like I said, I thought half-life dictated withdrawals too at one time.

 

[bingey]

well i dont know for sure so i will give you the benefit of doubt , the opiate receptor stuff doesn't make much sense though how can you explain that heroin has a shorter withdrawal than buprenorphine?


found a short article on benzodiazepine withdrwals this dude seems to agree half life and metabolites are key in the length of withdrawals

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1268424&blobtype=pdf

 

[Unknown]

You did an edit on me!

oh and half life means the time it takes for half of the drug to leave your body

A half-life is when the elements are 1/2 active.

ps I wonder if the way the drug is administrated effects WD too , like intravenous use giving shorter but more intense withdrawals could definately see that coming however now im just ranting

Method of Administration (MOA) can dictate a drugs half-life, bioavailability (BA), and potency of a drug. Withdrawals can be worse than other MOAs because of the BA of the drug is different per methods of administration.

 

[Unknown]

well i dont know for sure so i will give you the benefit of doubt , the opiate receptor stuff doesn't make much sense though how can you explain that heroin has a shorter withdrawal than buprenorphine?

I can and will explain this when I move from my smartphone to a computer.

found a short article on benzodiazepine withdrwals this dude seems to agree half life and metabolites are key in the length of withdrawals

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1268424&blobtype=pdf

Benzos and opiates are different, but have only the dependance similarlies. I will read and reply soon.

 

[Mr Blonde]

obviously methadone and bupe withdrawals will be longer than morphine or heroin withdrawals on the other hand codeine which only lasts about 4 hours has the same lenght of withdrawals as morphine (maybe the pro druh thing but i think it was proven it actually has another mechanism which makes it work)

Codeine converts to morphine, which provides the high and most of the analgesia, so the half-life of codeine, morphine and heroin are roughly the same. Codeine itself has a half-life similar to morphine's anyway.

 

[sixpartseven]

No. The speed at which it leaves your system has very little - if anything at all - to do with tolerance.

Tolerance is your body getting used to the amount you are taking in, not the amount you are getting rid of.

Also, shorter half life usually means quicker onset of withdrawals, but it doesnt necessarily mean worse withdrawals.

 

[Unknown]

^^^The two mods above me said pretty much what I was going to say regarding my last post. The question with bupe and withdrawals is, because bupe is a partial mu antagonist. It works 30 times stronger than morphine on your pain receptors, but is not effective on eurphora and physical dependence. I dont claim to know 100% about suboxone, but I have this general idea. So methadone and bupe aren't really a comparable drugs to do the difference of antagonist effects.

As for heroin, it is the street name for diacetylmorphine. all the "diacetyl" means that there is a double bond to cross the blood brain barrier much quicker than morphine, which doesnt have an acetyl group. This being said, heroin is morphine, but which a much quicker on-set.

 

[sonnyluv]

I often wonder about Reglan or metoclopramide. In addition to being an opiate agonist it also has prokinetic activities with the GI system which is why its used as an antiemetic for chemo. If you speed up the GI to prevent nausea, wouldn't it also push the opiate out of the system faster? But this certainly doesn't take into account how fast a substance is simply absorbed into ones system. Ponderous...

 

[hitomaro]

in regards to sixpartseven's post

actually yes it does, it is one of the factors that has to do with a build up of tolerance (there are quite a few, also implicated in the severity and duration of withdrawals experienced)

tolerance builds up as a result of over-stimulation of a particular receptor (opioid receptors in this case) which leads to down-regulation and desensitization blah blah blah. but! the longer a drug is circulating in your body, the more time it has to associate with its target receptors and thus stimulate them. so! the quicker a drug is removed by your body (a smaller half life) theres a lesser chance for the drug to build up a tolerance.

that being said, whilst this factor is not as significant as other factors such as the drugs affinity/efficacy or bioavailability/method of admin, it can still play a significant role. so yes tolerance is your body getting used to the amount your taking, but the rate at which your body removes the drug directly effects this. and yes again a shorter half life does mean a quicker onset of withdrawals, but can also effect the severity and duration of withdrawals aswell.

well thats how i understand it anyways.

 

[Unknown]

in regards to sixpartseven's post

actually yes it does, it is one of the factors that has to do with a build up of tolerance (there are quite a few, also implicated in the severity and duration of withdrawals experienced)

tolerance builds up as a result of over-stimulation of a particular receptor (opioid receptors in this case) which leads to down-regulation and desensitization blah blah blah. but! the longer a drug is circulating in your body, the more time it has to associate with its target receptors and thus stimulate them. so! the quicker a drug is removed by your body (a smaller half life) theres a lesser chance for the drug to build up a tolerance.

that being said, whilst this factor is not as significant as other factors such as the drugs affinity/efficacy or bioavailability/method of admin, it can still play a significant role. so yes tolerance is your body getting used to the amount your taking, but the rate at which your body removes the drug directly effects this. and yes again a shorter half life does mean a quicker onset of withdrawals, but can also effect the severity and duration of withdrawals aswell.

well thats how i understand it anyways.

Getting back on topic, I agree with this statement, as it was pretty much what I said. I still disagree that the shorter half life will effect the severity and duration of withdrawals. They may effect when one starts withdrawals, but like I said in my posts, half life does not define the strength of the drug or how they act on brain receptors.