A little maybe. But most of it will dissolve in cold water. Make sure the water is cold. COLD, not cool.
I guess that at least 95% of the hydrocodone will dissolve in the water. When dissolving oxycodone pills in water or buprenorphine pills/strips, most of the drug dissolves. At least 95% in most cases as shown in one of the micron-filtering threads.
As I said: I wouldn't want that much APAP (paracetamol) in my body. Just crush up your pills, stir them in cold water, wait a few minutes, then filter it and drink the liquid. That's how I'd do it - but I haven't done a CWE for oral consumption. I 've shot oxycontin for bout 18 months (I use micron-filters for everything!) - I guess that's similar to a CWE for oral consumption. I just crushed up the pill(s), stirred the powder in cold water, filtered it with cotton, then filtered it with a micron-filter (you don't need to do this, that's just for shootable drugs and I.V. use) and shot it.