Simply put! Depends On The Brand. But Mostly the AGE of the Tire. If your Talking [KNOLL] from Many a Moon Ago; Then crush'em, practically turning into a nice soft sand if possible. Pull-Out-Plunge, Crease The Shiny Crush Paper, Pure'em Down Barrel, Draw Approx. 20-30ml/of warm H2 O / per ea. 4 mg yellow sized. Shake Fast, and Do not stop til Set. Make Final Incremental Push til u jus hav Liquid, No Air space. Be Certain NOT to Jam Borehole w/ Floating Deposit. Upon Entering that Blue Blooded River, make a Gentle Draw to (Ensure) {a Hint/a Smokey Sign} Of RED, Confirmed Blood has Infiltrated the barrel. Once Satisfied, [Keeping { a Steady & Most Importantly, Angular Throat Twixt I.P, Insertion Point & Limb ( Thorax ), etc. Depending on Amount of Fluid & Self Knowledge, be Safe & Register @least Once. Again The Age of Manufacture, Pharm. Company, Size Barrel & Guage of Instrument holds the Trump Card on course of Events. It is My Experience that Neither Inhaling or Running these NEW TABS makes a Difference, b/c of the Science. Sublingual, Crushed n Parachuted, much safer, much the Method they were Designed for. LOL , Only u Know the Truth! God Speed/ J.S.