DeathIndustrial88
Bluelighter
Absolutely! My pleasure! Anything I can do to help!Thank you for your insight, DeathIndustrial88!
Oxycodone is metabolized by the CYP3A4 pathway, so you could try drinking grapefruit juice with your oxy to extend the duration of analgesia. But it's also possible some of the other meds you're on could be metabolized by this pathway (I'm not sure). So doing this could potentiate more than just your oxycodone.
Oral antifungal meds are also CYP3A4 inhibitors, like itraconazole. I actually took itraconazole recently a few months back & felt like it potentiated my buprenorphine but only slightly.
If you look up "CYP3A4" inhibitors, it should show you what drugs & foods will inhibit this enzyme, which will slow down your metabolism of oxycodone.
The gabapentin will work wonders for opioid withdrawal. I take about 900-1,200mg of gabapentin myself every day. It should absolutely help in the right doses.
Dextromethorphan is another thing that can help tremendously. It's the main ingredient in Robitussin & OTC cough meds. Make sure to only use products that contain DXM and nothing else. Taking 30-90mg of DXM can help potentiate an opioid. Taking higher doses can actually help with withdrawal big time but the higher dose causes a dissociative trip & I don't think you're trying to go for that. lol
I use to take small doses of DXM, loperamide & tonic water when I had withdrawals. Some times it helped, some times it didn't do much.
Tizanidine can potentiate opioids. My sister gave me some of those a few years back & I snorted some of them (because I'm an addict & like to snort things lol) and it knocked me on my ass. I believe it's related to clonidine but is more of a muscle relaxant.
The vyvanse should also help. I'm surprised you're able to get all of these meds honestly! lol The gaba, vyvanse & tizanidine should be doing at least a little to help keep withdrawal at bay.
And yes, you may need a little bit higher doses of loperamide than that. Supposedly no more than 8mg a day of loperamide is safe. Some sites say no more than 16mg a day... So I would hover around that area & see if it helps any better.