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I Like to Draw Pictures of Random Molecules

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yo pharmakos, with dat cisplatin in your body you should be able to give some anecdotal evidence!

(I hope you are doing well regarding the circumstances... :) )
 
Less talk, more structures!

Aminotetralin inspired structural isomer of MDPHP.

6-(pyrrolidin-1-yl)-2H%2C5H%2C6H%2C7H%2C8H-naphtho%5B2%2C3-d%5D%5B1%2C3%5Ddioxol-5-one.png
 
But the Gods are immediately perceptible to each other, as quickly as like is to like, and so too had M. de Charlus been to Jupien.
 
roi said:
Should be similar as methadone

1-(furan-2-yl)-2%2C2-diphenyl-5-(pyrrolidin-1-yl)pentan-1-one.png
Click to expand...

I have a /lot/ of these drawn up! The patterning in the open chains is beautiful. What got me even more excited was Piritramide; it's (almost) pethidine jammed onto where your pyrollidine ring is. I had a chance to try it last year actually, lovely compound.
 
This is probably a rookie mistake but something got to me this morning; Shulgin missed out one of the TMAs. It's this one:

67sA05Y.jpg


Is there any reason why he missed it out or does the a-methyl flip round to make TMA-3 or something?
 
sekio said:
ss%20(2016-04-15%20at%2002.23.28).png


hydroxyflunitrazepam water soluble prodrug aka "super roofies"

drug companies in india take note
Click to expand...

Heh! I had a similar idea: Nitrifluorazolam

uYW9nTZ.jpg


I love the water soluble touch though, you could take a page out of Rilmazafone's book there. Something like this:

UUnxQSW.jpg
 
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Final one, I swear. So...I started out by trying to make a lefetamine analogue but with oxymorphone attached to one of the phenyls, then I got a bit carried away and made a sort of "cube" (I can't remember the word for a six sided 3D structure, it's not even that anyway) from it's arch. I'm 99% sure it will never work but what about the possibility of creating 3D structures over morphine aside from the original arch?

loFMzFg.jpg



Ooh and quickly; is there any possibility of a dioxycyclobutyl (not really butyl anymore though!) ring instead of an MDO on amp? Eg:

Su2RAz9.jpg
 
blueberries said:
Final one, I swear. So...I started out by trying to make a lefetamine analogue but with oxymorphone attached to one of the phenyls, then I got a bit carried away and made a sort of "cube" (I can't remember the word for a six sided 3D structure, it's not even that anyway) from it's arch. I'm 99% sure it will never work but what about the possibility of creating 3D structures over morphine aside from the original arch?

loFMzFg.jpg



Ooh and quickly; is there any possibility of a dioxycyclobutyl (not really butyl anymore though!) ring instead of an MDO on amp? Eg:

Su2RAz9.jpg
Click to expand...

Artemisinin is the only drug I know with a peroxide bridge. In your particular case, there would be too much strain as well. See how in benzocyclobutene, the square isn't really a square, it is more a trapezium, because the phenyl bonds are trying to project from an angle of 120 degrees. I guess the same issue would happen here, but only with a much more reactive moiety. https://en.wikipedia.org/wiki/Benzocyclobutene#/media/File:Benzocyclobutene-3D-balls.png
 
blueberries said:
This is probably a rookie mistake but something got to me this morning; Shulgin missed out one of the TMAs. It's this one:

67sA05Y.jpg


Is there any reason why he missed it out or does the a-methyl flip round to make TMA-3 or something?
Click to expand...

That is TMA-3 :)
 
Yeah, I figured soon after!! There's definitely something interesting there though, I was reading the Isomescaline entry earlier. Fascinating. I wonder what could activate them both? I mean it's said that DMT is present in schizophrenic patients' urine, so perhaps it's something there; maybe sigma in spades! Then again there's probably a lot more going on than just DMT so it's anyone's guess. Also what's even more interesting is the difference in potency between MMDA and MMDA-3a. If we're following the 2,3,4 rule, shouldn't MMDA-3a be inactive instead of 4-5x the potency? The difference seems to be TAAR1 agonism, so perhaps the key to treating schizophrenia is with TAAR1 antagonists? So; https://en.wikipedia.org/wiki/EPPTB

Sorry I was kind of thinking aloud there!
 
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