• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

I Like to Draw Pictures of Random Molecules

Status
Not open for further replies.
Yeah, that was a rather unconventional interpretation of fried. If it managed not to polymerise or autocyclise then it'd probably be all kinds of toxic!
King Kong said:
Otherwise, I would be very interested to know more on the properties of this cyclic version of mescaline:

2zdqc84.gif


It doesn't fit in the classical SAR of psychedelics or stimulants, but it's quite close to pellotine, which is the main alkaloid of lophophora diffusa (old source: http://www.ncbi.nlm.nih.gov/pubmed/647075 ).
So, could be active!
Click to expand...

Reminds me rather of Lorcaserin, the diet drug which just got approved despite being a significant 5HT agonist.

Lorcaserin.png
 
^Why the 6-methyl?

I imagine 6-(2-aminoethyl)benzofuran (6-apb without the 'a-methyl'?) would be inactive since MDPEA is, but would 6-(2-aminobutyl)benzofuran be? I'd guess MBDB vs MDMA / Butylone vs Methylone kind of 'downgrading', probably not a winner but active.

Also, cathinone analogue of 6-apb [ 6-(2-amino-propan-1-one)benzofuran ] might be active, but then it would be unstable due to dimerising so we'd need a N-Methyl on that and with the difficulty of synthing 6-MAPB, I can't imagine we'll see this in the forseeable future.

I wonder how trading out Tryptamine's Nitrogen for an Oxygen to produce 3-(2-aminoethyl)benzofuran would work for tryptamine derivatives - we could get N,N-DM... EB? BF? Numbering system is same so we could get the 4-HO/5-MeOs.
Saying that, doing the reverse (tryptamine->phenethylamine structure) didn't exactly work for 5-IT (5-API). I was going to suggest 6-API but Shuglin got there first on that one.
 
Last edited:
MrPorter said:
^Why the 6-methyl?

I wonder how trading out Tryptamine's Nitrogen for an Oxygen to produce 3-(2-aminoethyl)benzofuran would work for tryptamine derivatives - we could get N,N-DM... EB? BF? Numbering system is same so we could get the 4-HO/5-MeOs.
Click to expand...

My idea was to reduce polarity. I actually meant to put it at the 5 position but I fucked up :\ If I recall correctly, there is a paper that Dave Nichols published a few years back investigating various tryptamine analogues. If my memory is indeed right, it was either the indene or benzothiophene analogues that had the highest affinities for 5ht2a.
 
Shulgin mentions these 2 under the BOD entry in PIHKAL =D lol

D.E.A (3,5-dimethoxy-4-ethylamphetamine)

DEA_zps9e236f62.jpg


I'm assuming this one would be active and a psychedelic. The next one I'm guessing would be a stimulant? if active at all? Did I even draw it the right way? I'm not sure.

C.I.A (4-cyclopropylmethyl-N-isopropylamphetamine)

CIA_zpsab94e920.jpg


sekio said:
I heard y'all like cyclopropyl groups.
200px-Syntin.png

http://en.wikipedia.org/wiki/Syntin
Click to expand...
LOL :D It looks like a joke, ha, awesome.

sekio said:
https://en.wikipedia.org/wiki/Sulfur_mustard

you would almost certainly not want to try it.
Click to expand...

Would the Chloro-thio-methyl functional group come off in the body and be poisonous like mustard gas? I guess that what your saying, right?
 
Fagott said:
Would the Chloro-thio-methyl functional group come off in the body and be poisonous like mustard gas? I guess that what your saying, right?
Click to expand...

Kind of - the chlorine comes off to give a sulfonium ion, which is really good at binding to DNA and lots of other things.

Loving those other two you've drawn
 
Transform said:
Kind of - the chlorine comes off to give a sulfonium ion, which is really good at binding to DNA and lots of other things.

Loving those other two you've drawn
Click to expand...

Hmm, so it's a mutagen? No big deal, I come into contact with mutagens everyday! Bring on the 2C-Mustard-gas.

To Fagott: I like those 3,5,dimethoxy 4-substituted phenethylamines without that oxygen. cool stuff. I wonder what a methylthio or a trifluoromethyl or a diflouroethylthio group would do here. I wonder if it's possible.
 
3v5jSEw.png


I've done it guys. I've created the ultimate molecule. It literally has everything you need. The hydroxylamine looked unstable so I figured a cobalt complex will stabilize it. Then water displaces the cobalt in vitro and the molecule unfolds in all its glory. With the spiritual awakening this will grant its users, surely world peace is imminent.
 
Possibility of New Opioid (spit-balling ideas)

Would it be possible to engineer a µ/δ agonist with comparable strength to morphine that also acts as a selective, H1/2 antagonist? The idea came to me tonight thinking about how itchy this OP 80 has made me. A powerful opioid that keeps one from getting itchy and nauseated would just be so bad ass.
 
You should go to the draw random molecules thread. I think maybe a mix of diphenhydramine and tramadol's structure would work. lol
 
Jktm said:
Would it be possible to engineer a µ/δ agonist with comparable strength to morphine that also acts as a selective, H1/2 antagonist? The idea came to me tonight thinking about how itchy this OP 80 has made me. A powerful opioid that keeps one from getting itchy and nauseated would just be so bad ass.
Click to expand...

Delta agonists tend to produce convulsions. Why do you want delta agonist activity tacked on there in the first place?
 
The reason for the delta agonism would be for the additional analgesia.
 
Is there not some animal toxin (a cardiotoxin perhaps?) that has many many ether groups in sequence?
 
Status
Not open for further replies.
Top