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I Like to Draw Pictures of Random Molecules

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ulD6fnc.png
 
The primary effect of the close amphetamine analogue is as a psychedelic and cathinones need the N-methyl group for stability, which destroys psychedelic activity.

That would probably leave a pretty second rate stimulant. Why the a-ethyl chain?
 
My mistake, I'm a tad hungover, this was meant to be what I was drawing:

VQv26JF.png


I don't really know my SAR at all other than making basic comparisons between similar drugs and what effect the change in structure has on their overall effects, so my thinking may be completely along the wrong lines here but I was looking at Buphedrone's structure and thought it might be more interesting if one could shift the balance towards more serotonin release and maybe some 5-HT2A activity.
 
transformer said:
The primary effect of the close amphetamine analogue is as a psychedelic and cathinones need the N-methyl group for stability, which destroys psychedelic activity.
Click to expand...

I would argue that the primary activity of the amphetamine analogue is entactogenic instead (as it substitutes fully for other serotonin releasers in animal experiments, but only partially for LSD). The very few human trials that have occurred (I've read of 2...RIP, coolio :/) suggest effects similar to MBDB.

However, the extended alpha chain and beta-ketone group of the compound shown suggest primary activity as a reuptake inhibitor, not a releaser, and reduced affinity for SERT. The SAR here is completely different from amphetamine skeleton compounds, and you can't really coax anything except for different selectivities for NE vs. DA and overall potency (that's at least what we've seen with the plethora of crap built from the pentadrone and buphedrone skeletons).

ebola
 
Does someone know of an example of a drug that is an NMDA antagonist and mu agonist with similar degrees of efficacy, i.e. both effects are felt at about the same concentration?
 
k7apuHA.png

Dicyclopropyltryptamine. Not particularly original but as there is a report of McPT being active, this sort of made sense. Anyone know if this has been synthesized (and tested)?

I have been reading BL for years, but this is my first post so please let me know if this breaks any rules/conventions and I will update it appropriately.
 
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sipete said:
k7apuHA.png

Dicyclopropyltryptamine. Not particularly original but as there is a report of McPT being active, this sort of made sense. Anyone know if this has been synthesized (and tested)?

I have been reading BL for years, but this is my first post so please let me know if this breaks any rules/conventions and I will update it appropriately.
Click to expand...

the cyclopropyl groups sort of look like trumpets or speakers, and therefore i hope this molecule produces action similar to the diisopropyl :)
 
oBlbYy5.png


Now we have trumpets (and severe abuse of chemistry).

Also, regarding DCPT activity, I would speculate that it would be closer to DPT than DIPT as the level of auditory specificity of DIPT seems to be extremely rare. I suppose this makes it statistically less likely that DCPT will be close in action to DiPT, but I am just guessing really. Does anybody that knows tryptamine SAR have any ideas?

Also also, that is some pretty interesting looking rocket fuel! Unfortunately, I have now lost an hour reading about different types and the history of rocket fuel.
 
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thenightwatch said:
2w71dns.png
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I would like to see the pharmacokinetic of this one.


Otherwise, I would be very interested to know more on the properties of this cyclic version of mescaline:

2zdqc84.gif


It doesn't fit in the classical SAR of psychedelics or stimulants, but it's quite close to pellotine, which is the main alkaloid of lophophora diffusa (old source: http://www.ncbi.nlm.nih.gov/pubmed/647075 ).
So, could be active!
 
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