Also, to my knowledge, nobody but rats and monkeys have been trialed on wierd ass D1 full agonists. I can only imagine using such a drug would have an effect somewhat similar to that of a rampaging bull in a china shop on the psychology of most people. A drug with no primary effects - not a stimulant nor a depressant nor a hallucinogen, that just induces reward? Seems like something out of a bad remake of Limitless...
The first molecule was being used to showcase its own uniqueness, antidepressant with anorectic properties producing wakefullness.... but also producing sedation? Just seems a bit crazy to me and I was giving that to dingophone to chew on, these things can be a little crazy.
The last 2 I listed did have primary effects, to quote the wiki article(s):
A-77636 is a synthetic drug which acts as a selective D1 receptor full agonist.[2] It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies,[3][4][5][6][7] but its high potency and long duration of action causes D1 receptor downregulation and tachyphylaxis,[8][9][10] and unlike other D1 full agonists such as SKF-82,958, it does not produce place preference in animals.[11] A-77636 partially substituted for cocaine in animal studies, and has been suggested for use as a possible substitute drug in treating addiction,[12] but it is better known for its use in studying the role of D1 receptors in the brainstimulant effects
SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist.[1][2] SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.[3][4][5][6][7][8][9][10][11]
Not to say they shouldn't stay with the monkeys and rats but they do seem to be interesting compounds.
