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I Like to Draw Pictures of Random Molecules

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Very cool, TOT and TOET look pretty rad.

Has anyone looked into 5-isopropoxy tryptamines by the way? The substituent might be too bulky, but the resemblance to 5-EtO-DMT (which IRC is active) is too tempting...
MVi36NC.png
 
There are drugs like 5-nonyloxy-tryptamine that have been synthesized, they are selective for the 5ht1d receptor, may or may not be worthwhile in humans; I haven't read of any bioassays.
Right, the long alkyloxy chains certainly improve affinity for 5-HT1d, but unless I'm mistake the shorter alkyloxy chains (methoxy, ethoxy, ?isopropoxy?) have greater affinity for 5-HT2a. I guess the big question is here is whether or not isopropoxy is too big to fit the receptor or not.
 
Q2JW1sa.png

I think something like this was already done with Fluor

Also, was thinking about replacing the oxygen in MDMA with fluor, like 3,4-difluoromethanemethamphetamine. But I don't think that's a valid thing.
QPvDyur.png


Bit of a random question, what are the requirements for an analogue to produce effects ? I have been drawing a lot just for fun the last few hours and the things I took in mind where shape and positive and negative fields.
 
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^^
fluorine does not do that.
and i'm pretty sure the first compound is quite impossible too. even if it were possible, it would be highly mutagenic.



i've been playing with the 5-ht2b receptor model and this thing should fit in nicely:
1pylw5.png


it could be a psychedelic and serotonin releaser (probably more of a releaser; even more so and less of a psychedelic when you attach another methyl to the N on the left).

another thing that could be interesting is dmt with the nitrogen fixed in lsd's configuration:
1j5cvs.png
 
compounds like that chopped down LSD are known and active as 5ht1a agonists I think.

yes, apparently a similar compound (like the molecule above, but lacking the double bond in the upper ring and of course with the fully aromatic indole, which i forgot) has already been tested and called RU 28306, but it's selective for 5-HT2 over 5-HT1. but it's quite an old paper, they're only talking about the 5-HT2 receptor...

edit: there's also a patent of the N,N-dipropyl analogue of RU 28306 as a prolactine inhibitor.
 
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why 5HT2B? just for novelty's sake? i always thought 5HT2B activity contributed more to side effects.

because they recently made a model of the 2B receptor and someone posted it here in ADD. :)

and i don't think that 5-HT2B is that bad at all. activation of 5-HT2B is apparently necessary for mdma-like serotonin release and most nice psychedelics have some affinity for it (lsd has a higher affinity to 2B than any other receptor).
 
in the wiki entry for 5-APDB, there's mentioned this:

"Methoxy-substituted analogues of 5-APDB and 6-APDB have also been made and substituted for DOM in animal tests, although they were around 10x less potent than DOM!"

What are these? I really can't get my head around were these methoxy groups are supposed to go? 2,5 on the phenyl ring?

Also, I'm wondering if the Isobenzofuran analogs of MDA/MDMA could be possible? or maybe they have already been looked into?
 
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What a coincidence ! I was also thinking about isobenzofuran this week!

I think the compounds are called IBF5AP and IBF5MAP (They might have different names though, because I couldn't find much about them.)
 
I would be shocked if the isobenzofuran analogues were stable enough to be affordable to produce or practical to store.

"Methoxy-substituted analogues of 5-APDB and 6-APDB have also been made and substituted for DOM in animal tests, although they were around 10x less potent than DOM!"

Most likely the analogues of MMDA?
 
What a coincidence ! I was also thinking about isobenzofuran this week!

I think the compounds are called IBF5AP and IBF5MAP (They might have different names though, because I couldn't find much about them.)
Nice, there they are :) Seems they are in the Shulgin index. Who came up with the APB/APDB names? by the way, and what do they mean? 3-desoxy-MDA and 4-desoxy-MDA makes alot more sense imo.

Yeah, I guess that must be it...
 
The AP(D)B names are just abbreviations of the IUPAC naming schemes: 6-(2-aminopropyl)benzofuran
 
PB22 weirdness

200px-PB-22.png


OK so many of you might not be familiar with this compound, it's the latest cannabinoid synth attempt to get around recent US and UK bans.
I have a real issue with this compound, I feel that it activates 5HT2A receptors and also acts as a partial NMDA antagonist.
I think people will be getting themselves into lot's o' mess with this one.
Bizarre, isn't it, to think that the major players in construction of the advance of psypharm is not in fact global science but bureaucracy.
 
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