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N&PD Moderators: Skorpio
I Like to Draw Pictures of Random Molecules
- Thread starter nuke
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Incunabula
Bluelighter
- Joined
- Dec 10, 2010
- Messages
- 1,861
last one: methylenedioxy-methylphenidate
ha ha
sekio
Bluelight Crew
azetine rings are rather hard to construct.
also, blowjay, many of those compounds are hemiaminals, ketals, or lactones, so they wouldn't be very stable.
spephspeph
Bluelighter
What happens if you add an acetyl group to the beta position on phenethylamines?
you mean like this:
?
then you'd get ephedrine and acetic acid because it's quickly cleaved by esterases.
spephspeph
Bluelighter
What would be the point?
For moronic ideas: how about the nitrate ester of ephedrine?
It'll counter the increased blood pressure
or explode
haha
but why stop at one nitro group? trinitro-ephedrine would be fun, who doesn't like drugs with explosive effects
pharmakos
Bluelighter
speed that you can really bang
How about the last one, any thoughts on it?
ebola?
Bluelight Crew
hammilton said:
Let the future of terrorism be explosives concealed as research chemicals.
ebola
dingophone
Bluelighter
That's super cool, 3,4-MDPCP?
Was wanting to throw this one out there last time since 3 and 4 meo exist, why not bridge them? I'd like to see the pharmacology of that one haha.
Here's some things I've come up with recently.
DMAA-based tryptamine analogue:
Non-hepatotoxic analogue of amineptine:
Methylenedioxybenzofuranylpropylaminopentane or, MDBPAP!
That's super cool, 3,4-MDPCP? I'd like to see the pharmacology of that one haha.
Here's some things I've come up with recently.
DMAA-based tryptamine analogue:
I liked this one, have always been interested in DMAA having activity, makes me wonder how much of a ring system is really needed for some recreational activity, propylhexedrine always intrigued me, what would a cyclohexene ring do instead and what about placement of double bond?
I am wondering about analogs of Phenmetrazine as well, why not move the oxygen over one closer to the nitrogen and see what that does of why not just replace said oxygen with a carbon instead?
http://www.chemspider.com/Chemical-Structure.14447455.html
Hell, why not methylate the nitrogen while we are at it?
Someone entertain my ideas, always wanting to 'learn' (or at least ask questions).
dingophone
Bluelighter
For some types of activity it certainly seems necessary. For this one, I would wonder if the absence of the pyrole ring would make a huge difference. It might prevent 5ht2a binding, but I'm not 100% sure. I think it might still have SERT affinity though, and might act as a releasing agent. Some cyclohexene ideas have been thrown around before actually, and I think it's a ripe field for discover
I'm not honestly sure how removing the nitrogen would affect it. I would assume it would keep some sort of dopaminergic activity based on the structure of amineptine, but it could be a reuptake inhibitor rather than a releasing agent. Changing the position of the oxygen probably wouldn't change much.
Haha they actually have done that: http://en.wikipedia.org/wiki/Phendimetrazine
Makes it into a prodrug!
Also, here's something else I made hoping to find a dopamine agonist/reuptake inhibitor and GABA transanimase/reuptake inhibitor (based on dopamine and bamaluzole/muscimol):
Last edited:Also, here's something else I made hoping to find a dopamine agonist/reuptake inhibitor and GABA transanimase/reuptake inhibitor (based on dopamine and bamaluzole/muscimol):
http://en.wikipedia.org/wiki/A-68,930
Check out this interesting fellow, not quite what you were wanting but very interesting IMO.
I am a bit interested in this guy below
http://en.wikipedia.org/wiki/A-77636
I find bromantane is useful and have stumbled on (distantly) related stimulants, the anxiolytic + stimulant combo is very ideal.
As an added bonus I will throw in another interesting dude below:
http://en.wikipedia.org/wiki/SKF-82958
I hope you find these at least mildly interesting, dopamine agonists seem to be extremely variable and have always intrigued me.
Would love to find 'functional' dissociative with mild dopamine release, IMO this would be the perfect everyday boredom buster. Tune out everyone else but your self and your ambitions/duties and have motivation whilst doing so. Maybe throw in some neuroprotective properties for good measure but ehh sometimes we think a bit too much.
sekio
Bluelight Crew
dingophone, that compound would sooner fall apart than be absorbed by a human cell. Typically the N-CH2-OH motif is pretty... uncommon warranting to its ability to decompose to formaldehyde and an amine.
Aromatic rings are needed for activity at most transporter sites and things like serotonin receptors - the exception tends to be the adrenoreceptors which seem to be pretty promiscuous for alkylamines especially (see, for instance, tuaminoheptane... possibly one of the simplest drugs?). I think NET has a little tolerance for bulky alkyl groups in general, but remember that propylhexidrine (hexahydro-dextro-methamphetamine) is about 1/100 - 1/1000 as potent as the drug it is 'derived' from !
Nobody gets arrested for extracting nasal inhalers to sell on the street, either...
Also, to my knowledge, nobody but rats and monkeys have been trialed on wierd ass D1 full agonists. I can only imagine using such a drug would have an effect somewhat similar to that of a rampaging bull in a china shop on the psychology of most people. A drug with no primary effects - not a stimulant nor a depressant nor a hallucinogen, that just induces reward? Seems like something out of a bad remake of Limitless...Last edited:- Status
