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I Like to Draw Pictures of Random Molecules

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How about these things..


Had this in my head all day. I'm thinking that with the N-Benzyl, my (Originally DMT, now NMT) molecule will remain sigma agonistic properties, while being a strong 5-HT2A antagonist. Antidepressant effects?
UA4qn.png


And if MAO devours that compound, how about an ethyl instead of the methyl?
QHDcU.png
 
^ You may be interested in this paper, I haven't looked through it completely but it may actually cover these compounds. (in German)
 
This is the perhaps one of the most interesting ongoing thread here, I wish to contribute some of my humble doodles (enpenetrate sodium, etc). However, I need a chemdraw app for this new android device; any suggestions? On my last device, I failed to find an app the worked well, so I ended up using a CAD program designed for engineering.....
 
Those are not amine nitrogens though, delocalisation of the lone pairs into the C=N should make the hemiaminal type things more stable.
 
How about leaving the ring open, like in the original compound posted?
 


Would something like this be active? Not that i would want to try it anyway, the thaught just occured to me. Also any other beta-ketones were the carbonyl group is replaced with a thioketone group. Maybe the compound would be unstable, thioketones dont tend to be the most stable compounds.
 
tryptalin would be the tradename for methyltryptidate, no? (or methylindolidate perhaps)

instead of that methyl "up top" you could have that oxygen connect to the "4 position" on the phenyl, for obvious reasons IMO :)

lol thats a structural analogue of 4-AcO-MPT if i am looking at it right :) (with a bit of shuffling of the carbons/bonds)
 
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Anybody care to use their imagination on one of these from my thread on DRA DAT modulators (I have the upper right, SoRI-20041, in mind the most)...

F1.small.gif


...on ways of making them into functioning DA releasing agent as well?

An allosteric modulator of DAT of this type that is also a DA releaser may just be an optimized abusable dopaminergic.
 
3n7q2.png


Its a shot in the dark but would adding Nitrogen to the ring affect 5HT2A docking that much? If not then you have 2CBCB-Fly.
 
cannibalsnail said:
http://i.imgur.com/3n7q2.png
Click to expand...

Nitrogen cannot have five bonds because it cannot have an expanded octet. Phosphorus may though the phosphabenzene analogue of what you have drawn would most likely be very contorted/skewed whereas a fairly planar parent is believed to be preferred by the 5HT2A receptor for agonism. I'd recommend reading introductory general and organic chemistry texts.
 
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