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I Like to Draw Pictures of Random Molecules

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--> random molecules thread

If bisphenol A (BPA) in plastics can be estrogenic in humans, I see no reason this little gem couldn't possibly be an androgenic stimulant, no?
Click to expand...

BPA resembles estrogen much more closely than that cmpd resembles testosterone, check the space filling models of estrogen sometime. stuff like diethylstilbestrol also overlays nicely.

and as a rule of thumb any highly polar substitutions on the ring / dearomatization of the phenyl ring in amphetamine leads to weaker central activity
 
That tilidine sounds like an interesting one, glad it doesn't require CYP2D6 membership - the reason i can't enjoy tramadol :p

I think opioids for depression should be kinda tricky. I mean wouldn't the mood-lifting effects fade over time? It sounds analogous to BZDs for anxiety in that it should be very effective but unsustainable in the long term. Unless it's not the opioid effects you're saying should be useful for depression but some other mechanism like NMDA or something.
 
aced126 said:
Wouldn't nortilidine be void of most opioid activity
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It should be more potent, Tilidine is only a pro-drug for it but is so fast metabolized that I think it doesn´t make a big difference other than pure potency/mg ratio (Tilidine is used in doses from 25 to 400mg, Nortilidine should be more in the dosage of Morphine. This article also states the dopamine-reuptake effects I mentioned as well as nmda-activity which could contribute to it´s antidepressive effects like with Tramadol (but a hundred times more enjoyable than Tram, it´s the most abused "light-opioid" in germany for example and I know no one who would switch it for anything else. It´s stimulating effects also feel more like coke (very pronounced "sunshine feeling") than amphetamine.

Nortilidine[1] is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine[2] but virtually all of the opioid activity resides in the (1S,2R) isomer.[3] The (1R,2S) isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor.[4]
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https://en.wikipedia.org/wiki/Nortilidine
 
Does anyone know how this drug is called and if it was available on the rc market in the recent years? By searching for the name I couldn´t find anything useable. I remember reading it was used as a designer drug in Israel but can´t find the article.

2-(dimethylamino)-1-(4-methylphenyl)propan-1-one
5gadci4f.png



also some more molecules:

m88qzx7m.png
 
That's 4,N,N-trimethylcathinone. N-methyl-Mephedrone. Should be a barely active prodrug. Dimethylone/Dibutylone were rather big failures as well.

It has been sold as 4-MDMC (4-methyldimethylcathinone).
 
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Dresden said:
Here's my first 2C contribution to this thread:
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My God. How did you get in my head!? That Ethscaline was my pride and joy for god knows how long (coming from that glorious DESOXY)! Plus most of the rest have been drawn and fantasised by me too many times. The deuterium analogues also sailed through many times but attached to 2C's ala 4D. Those MMDA analogues too. IMO the 5 is much too weak but brain movies. The 2 is much more applicable for recreation but at one point I sincerely felt that the 5-Methyl-MDA myth was actually perpetrated by 2-Methyl-MDA (still could be...).

Plus roi; I love the PCP/Pethidine analogue. I did something similar with MXE and Ketobemidone.

Anyway; I got into these pseudo-halogens and found Cobalt Carbonyl. It'd be very bulky, sure, but you think it would allow it at 4, like this? It's a shot in the dark and even if you could use the Cobalt effectively, I don't want to know what would happen in vivo! It's another 2C-At type compound.

ksUYJd0.jpg


EDIT: Also on Tilidine, I should mention that when 4-MeO-PCP came out there was a certain supplier who had a lot of very dodgy compounds and foolishly (I was young) I got some DXM and 4-MeO from them. Both felt exactly the same at the same dose and I later heard a rumour saying that they were vending Tilidine instead. This corroborates my latter experiences of 4-MeO as it was wildly different. Wild being the integral word. It was pure chaos and not pleasant, unlike my 4-MeO experiences. I'm still glad I tried it though.
 
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blueberries said:
Anyway; I got into these pseudo-halogens and found Cobalt Carbonyl. It'd be very bulky, sure, but you think it would allow it at 4, like this? It's a shot in the dark and even if you could use the Cobalt effectively, I don't want to know what would happen in vivo! It's another 2C-At type compound.

ksUYJd0.jpg
Click to expand...

brb drawing 2C-B12
 
Exactly! Another 2C-At! I just wanted to know if it could actually be created though. I realise it'd be wholly unfit for consumption but I love the idea of having a compound, incredibly rare, fitting to the 2C archetype yet being completely untouchable. Kind of like forbidden fruit.

I mean besides the rampant toxicity, if some superhuman immortal type were to try it there would be an affect, no? Similar to 2C-At; there would be an affect if you could survive the toxicity/radioactivity. Who knows, maybe sometime in the future we'll get carbon tubing organs which make us invulnerable to any toxicity (probably still not Astatine though!). Then we could try it!

EDIT: And a carbon tubing brain!! Taking into account the ancient philosophical question of whether consciousness could survive if a new brain were implanted with memories reprogrammed into it...but let's just say it would!
 
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Ok, now for a serious compound. I began researching Quinazolinones recently and after the RC analogues to come out and having tasted real Methaqualone, I figured there must be a way to retain the affect of MQ while increasing potency. I went through nearly every paper I could find but on each one it seemed to lose. I did happen to gleam some nuggets of information though, which are:

- Replacement of any integral positions (2, 2', 3' & 4') with a halogen results in loss of affect but gain in potency. Dead-end.

- Addition of alkyls at any of these positions also reduced affect. Another dead-end.

- The 4 position increases potency some 4x, the 3 position increases it some 6x.

- Metabolites of MQ include hydroxy's at 2, 2', 3' & 4'.

Therefore with point #3 & 4, I created this. If nothing else it should be as potent as MQ, if it adheres to the rule it should be perhaps 3x the potency or more with a similar affect.

ElOzr6J.jpg


Thoughts?
 
I've always wanted to try this one but never have:

2-ethylamino-1-phenylpropane.png


The closest I got to trying it was the following:

1-phenyl-1-oxo-2-ethylaminopropane.png


It was only so-so, as many cathinones are wont to be.

blueberries,

I tend to think you'd have better results with:

2-methyl-3-(2-chlorophenyl)-4-(3H)-quinazolinone.png
 
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Whoa! Of the Quinazolinone? I just don't think in all honesty. I mean the structure is so out of line..I just don't see how it would work. I mean it could be an MAOI from there let alone a specific GABAergic compound that matches itself with MQ. Not even GHB can reach it's infamy.
However I'd still like to hear an explanation of such a compound!

EDIT: Ok I was a bit drunk and completely misread that compound. Aaaanyway 6-Cl compounds do increase potency somewhat but still need to have something anchoring the 2 position (as seen here: http://www.google.com/patents/US3162634). Halogens in general also ruin the affect of the compound as I have tried personally.

The only thing that works is alkyl bonds and well, not fucking with it...at all! MQ is just one of those divine compounds that can't have any analogue and unfortunately it hit the sweet spot at a low potency. Even with the 3-HO bond it still could have a similar potency or even have an altered affect but out of the possible combination it really is the best we can hope for.
 
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