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I Like to Draw Pictures of Random Molecules

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blueberries said:
Whoa! Of the Quinazolinone? I just don't think in all honesty. I mean the structure is so out of line..I just don't see how it would work. I mean it could be an MAOI from there let alone a specific GABAergic compound that matches itself with MQ. Not even GHB can reach it's infamy.
However I'd still like to hear an explanation of such a compound!

EDIT: Ok I was a bit drunk and completely misread that compound. Aaaanyway 6-Cl compounds do increase potency somewhat but still need to have something anchoring the 2 position (as seen here: http://www.google.com/patents/US3162634). Halogens in general also ruin the affect of the compound as I have tried personally.

The only thing that works is alkyl bonds and well, not fucking with it...at all! MQ is just one of those divine compounds that can't have any analogue and unfortunately it hit the sweet spot at a low potency. Even with the 3-HO bond it still could have a similar potency or even have an altered affect but out of the possible combination it really is the best we can hope for.
Click to expand...

what do you think about about an ortho-CF3 substitution? posted that in here a while ago

It's so damned easy to make such an analogue that I'd get a chinaman to whip me up some but I always seem to find better things to spend my money on
 
Oh, I'm not so familiar with methaqualone. The only thing I know about it is that etaqualone didn't work very well and stories in rehab from old addicts from the 70s saying how messed up they used to get on methaqualone. I have no idea that these two would work either, but anyway, they are pared down versions of amfonelic acid, one with a 2-benzyl and the second with a 2-piperonyl:

2-benzylpyridine.png


and

2-piperonylpyridine.png


And just for kicks (note similarity to amphetamine):

2-aminonaphthalene.png


I don't think I'd be willing to try this last one. But yeah, woke up feeling aromatic this morning, I suppose.
 
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blueberries said:
Ok, now for a serious compound. I began researching Quinazolinones recently and after the RC analogues to come out and having tasted real Methaqualone, I figured there must be a way to retain the affect of MQ while increasing potency. I went through nearly every paper I could find but on each one it seemed to lose. I did happen to gleam some nuggets of information though, which are:

- Replacement of any integral positions (2, 2', 3' & 4') with a halogen results in loss of affect but gain in potency. Dead-end.

- Addition of alkyls at any of these positions also reduced affect. Another dead-end.

- The 4 position increases potency some 4x, the 3 position increases it some 6x.

- Metabolites of MQ include hydroxy's at 2, 2', 3' & 4'.

Therefore with point #3 & 4, I created this. If nothing else it should be as potent as MQ, if it adheres to the rule it should be perhaps 3x the potency or more with a similar affect.

ElOzr6J.jpg


Thoughts?
Click to expand...

US Patents 3086910,3135659,3162534,3194806,3382246,3406173,3448109,3514466,3651230,396731,4276295,5283247

The BEST legal-lude isn't specifically mentioned - it was worked out using Intelligent Design and some time with Ames tests, affinity tests & metabolism tests. Like Pyrazolam - it exits the body unchanged so the dose doesn't have to be changed for the young, the old and those with comorbidities. I advise everyone to buy a copy of Vogals Handbook of Medicinal chemistry and Chemoffice. From there you will want unlimited Reaxys and lots of time. I'm interested if any of the chemists here still stick to rational design... if not, I'm interested in just how good these 'molecular guessing programs' really are. Tip - Watch out for AMPA affinity; all the later patents use the quinazolinones as a scaffold FOR AMPA ligands.

Hope this helps!
 
I will bet you these "molecular guessing programs" are not good at all. I wouldn't exactly call my design methodology "rational," either. Far from it.

Anyway, here's some shortish acting synthetic "legal" cannabinoid wax [literally] that I threw together for the stoners among us who nevertheless can't get real THC dabs or plant matter atm:

3-(2-hydroxy-4-(5-carbomethoxypentyl)phenyl)-cyclohexanol.png


And here's a JWH-018 variant:

1-(naphthalene-1-yl)-1-(N-(2-carbomethoxyethyl)-(indol-3-yl))-methanone.png


Which may be made into a short acting psychedelic by the addition of a 4-hydroxy indolic substituent:

1-(naphthalene-1-yl)-1-(N-(2-carbomethoxyethyl)-(4-hydroxyindol-3-yl))-methanone.png


Or just all around powerful but fairly short acting by the addition of a 5-methoxy indolic one:

1-(naphthalene-1-yl)-1-(N-(2-carbomethoxyethyl)-(5-methoxyindol-3-yl))-methanone.png


Anyway, just some Wax n' Facts (which are not yet known to be facts if they even are!) for your brain today. :)
 
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from US law:

Schedule I

...

(d)(1) Unless specifically exempted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of cannabimimetic agents, or which contains their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation.
(2) In paragraph (1):

(A) The term "cannabimimetic agents" means any substance that is a cannabinoid receptor type 1 (CB1 receptor) agonist as demonstrated by binding studies and functional assays within any of the following structural classes:

(i) 2-(3-hydroxycyclohexyl)phenol with substitution at the 5-position of the phenolic ring by alkyl or alkenyl, whether or not substituted on the cyclohexyl ring to any extent.
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i believe that molecule would fall under this definition.

blanket bans suck.
 
Yes, but the *real* question is: Is the compound legal in China, whose illegal compounds are listed specifically but not publicized or the subject of a blanket analogue act type ban, now? If so, it can probably be made for the right price, but you just don't want to get caught importing it or possessing it or distributing it in the U.S. as with any Schedule I drug.

While I'm at it, anyone know anything about 4-OH-AMT?

1-(4-hydroxyindol-3-yl)-2-aminopropane.png


Or 4-Cl-AMT?

1-(4-chloro-indol-3-yl)-2-aminopropane.png


I know 5-MeO-AMT is a horribly toxic, potent, sucksome drug.

Indolic N-pentyl-AMT might, potentially, be a winner of sorts, though:

1-(1-pentylindol-3-yl)-2-aminopropane.png


You can probably tell I'm on Adderall.
 
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I thought production and selling of illegal chems in china is legal if it´s for export only? Especially as many labs cooperate with the government like China Enrichment Labs (where "Eric Chang" works).

wmvxsvdu.png


can you replace a sulfoyl-thiol with a methyl-sulfonyl-methane unit without loosing activity?
 
so like, has no one considered the benzofuran analogue of aMT? I sure hope it's in the pipeline what with 5-MeO-DiBF seeing the light of day

Loved 5-APB, which if it isn't obvious this would be an isomer of; wonderful balance of the psychedelic with the empathogenic.
 
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I THINK the time has come to ask everyone look up 'Lipinski's rule of 5'

Also, use Marvinsketch for LogP & Pka - no use unless it's unprotonated at physiological pH.
 
Midnight Sun said:
so like, has no one considered the benzofuran analogue of aMT? I sure hope it's in the pipeline what with 5-MeO-DiBF seeing the light of day

Loved 5-APB, which if it isn't obvious this would be an isomer of; wonderful balance of the psychedelic with the empathogenic.
Click to expand...

3-(2-aminopropyl)-benzofuran.png


Seems like I saw the methcathinone benzofuran analogue of this for sale somewhere, don't remember where.

3-(2-methylaminopropan-1-one-yl)-benzofuran.png


Soulfake,

The 3,4-dimethoxy phens have proved largely and surprisingly disappointing.

clubcard,

What, are you assigning us homework? Just explain yourself. Many of us such as myself are not in college or high school anymore.

One time I finally got to try 3-MeO-MA, but it was very, very mild and frankly quite a disappointment, and I took 500mg:

1-(3-methoxyphenyl)-2-methylaminopropane.png
 
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lipinski's rule of five was pretty easy to look up

Lipinski's rule states that, in general, an orally active drug has no more than one violation of the following criteria:

- No more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds)
- Not more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms)
- A molecular mass less than 500 daltons
- An octanol-water partition coefficient[5] log P not greater than 5

Note that all numbers are multiples of five, which is the origin of the rule's name. As with many other rules of thumb, (such as Baldwin's rules for ring closure), there are many exceptions to Lipinski's Rule.
Click to expand...

thanks clubcard
 
Your welcome P - May I recommend the on-line Marvinsketch free software? Gives you the LogP AND pKa - if you medicine isn't unprotonated at physiological pH, it's not likely to work. Try methadone - now you can SEE why it's slow onset.... on the other hand, if you base it out and smoke it.... ahem.... forgive me, BAD IDEA!
 
X1ovS.jpg


sekio brought "NK-1145" to my attention in a PM, for whatever reason the benztropine-substituting-carbmethoxy style phenyltropanes but with isoxazoles, and changing the oxygen to a nitrogen at the linkage to the benzene as has been seen in other analogs, & voilà.

mLWD5.jpg


^my attempt to make the cyanotoxin "Very Fast Death Factor" (VFDF) into a cocaine like compound (seeing as cocaine can be a precursor in its synthesis, even)

Anybody know what the following compound is? Chemicalize.org says this is one in their database that matches as similar to the above one I was working on:
exo-8-Benzyloxymethyl-3-ethoxycarbonyl-4-hydroxy-1-azabicyclo[3.3.1]non-3-ene

it looks like:
MFI0E.jpg


Why would this show up as an attested compound? Something I've overlooked in my in-depth study of such compounds or am I being foolish and it is something obvious?

EDIT:

Finally, would something like this make sense? "Cupric cocaine benzoate?" ;-p

ipn6O.jpg
 
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Hello,

I read somewhere that the phenylethylamine is a very potent stimulant but is metabolized by the body too fast to be active. I also read that the utility of adding an alpha methyl group to the PEA to create an amphetamine structure prevent this destruction by blocking some enzyme. Is there a possibility for a non akyl group to act the same way ?

3Wee4GG.png
 
Now - one of those really IS active. the p-N version of (meth)amphetamine is known, but the LogP is less favourable so their are more physical side-effects. Just changing the 'beta' to use non-IUPAC, trivial names, to a CH2F makes active compounds. A I have said, they have BIG MAOI issues so this is purely informational - make them and your going to kill a lot of people. Durations are also LOONNGGG!
 
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