Cocaine I do not respond to drugs anymore, huge tolerance despite infrequent use.

[hematocritter]

Let me begin by saying that I have a huge tolerance to all medication; OTC, prescribed, and recs.
I have family members that are the same way.
Anytime I have messed with drugs around people that have a lot of experience, they always comment that I must have worked up to that dose over a long time.... they are shocked
when I tell them its my first time or that I have only done it 5 times in my life.

If I use drugs consistently at all, the effects rapidly decrease in a matter of days, to the point that it is foolish to even try again, I need months off to feel anything.


On to my question....
I am prescribed 300mg a day of Oxycodone. I still get pain relief, but I only got high from them the first month of use. I don't mind that, I am just glad to have my pain managed.
However, ever since I have been on this medication I have had even more tolerance to other drugs.

I have fooled with coke on and off over the last few months. Maybe 2-3 days in a row once a month. I noticed that the first line or two would be great, and then it was like nothing after that.
I tried crystal meth the other day (only done it 5 times in the last ten years). I barely felt it at all, despite my heart rate and BP increasing. I was also able to stay awake, but had almost no euphoria.

I am thinking that I have completely depleted my dopamine levels. I have read that oxycontin does that over time. Since I have been on it so long and I no longer get euphoria from it, I assume that is
what happened. Further supporting my theory is that cocaine and meth work primarily on dopamine (right?), and since the oxy has depleted those levels, then the coke and meth have nothing to work
with.
Does anyone agree with my theory? Or does anyone have any other explanation?

 

[pbuilder]

"I have fooled with coke on and off over the last few months. Maybe 2-3 days in a row once a month. I noticed that the first line or two would be great, and then it was like nothing after that. "

this is normal... that's why cocaine is so addicting lol you get this mind blowing euphoria from your first couple of lines and then u just kinda start tweeking the more you do after lets say the first hour, and the euphoria almost changes into just a "content" with chatting my head off type high, rather than the mind blowing, drooling in your chair high from the first lines, but because you remember that euphoria you just wanna do more and more but you will not get back that first high of the night lol.

Also, is it possible that maybe your meth was of low quality, thus you got all the tweek with no skeet skeet (euphoria lol), I don't think that opiates have to much of an effect on the dopamine systems, i was under the impression that they work in their own little opiod receptor circuit that is connected throughout the body but I don't really know the science so maybe I'm talking out of my ass.

 

[Dextromaniac]

Look into Opiate tolerance reversal with DXM. Some people who tried it say that when DXM was introduced with their opiate dose they required less opiates to reach their desired level of effects.

Tolerance is different for everybody, some get it fast some dont even get it at all. I don't have any knowledge of this but, your theory sounds like it could be possible but, theres probably a different reason.

 

[sir_thizzalot]

I am thinking that I have completely depleted my dopamine levels. I have read that oxycontin does that over time. Since I have been on it so long and I no longer get euphoria from it, I assume that is
what happened.

Does anyone agree with my theory? Or does anyone have any other explanation?

Smart call. I don't agree with either of the people posting above me, pbuilder- opiates work massively off dopamine, and Dextromaniac- that could be worth looking into, but I doubt it'd fix his problem here.

I know plenty of big pot heads who have a "natural" massive tolerance to pretty much every drug they try. When I smoked a lot for something like 6 months, I felt this greatly. I think in this case of weed it might both have something to do with lower DA levels, along with a slowed synapse (slower DA transporters). I'm no expert though.

I just know that I've seen many cases of an addict or long time user of one drug have a big tolerance to anything else they try. Low DA levels, possibly DA receptor down regulation, possibly a slower synapse, could all be part of it. DA is the main chemical in all the best known feel good recreactional drugs.

Not that I'd recommend adding coke to your drug use, but if you do, I'd recommend trying to go a little light on the oxy throughout the day, then take a normal or possibly slightly bigger dose, and start your lines right when you start to feel it. With the DA release, it should be a nice combo with the cokes DA reuptake inhibitor effects. The NA will (I think) be slightly depressed by the oxy, so when you do the coke it might be a little less energetic than it would be for most of us, especially a few lines in. The benefit of this combo is the oxy really helps the comedown. Mixing the two works pretty well, nothing like H and coke though.

 

[sir_thizzalot]

Also note that if you feel decent on your days where you only use your 300mg of oxy, you don't have completely depleted DA levels. If you always had that, you'd always feel like shit! You just have LESS DA than most of us, I'd imagine, but the oxy is still releasing some keeping you feeling "normal" or maby a little good. Hopefully.

 

[helium-4]

Being on 300mg of oxycodone will certainly effect the way you perceive other drugs. I've noticed with certain opioids amphetamine doesn't have the same punch as if I used the amphetamine alone.

 

[sekio]

Damage/deficiency in the dopamine system is not exclusively what you have (otherwise known as Parkinson's disease). It's a condition that can be more appropriately termed stimulant burnout.

 

[TheLostBoys]

Tolerance is different for everybody, some get it fast some dont even get it at all. I don't have any knowledge of this but, your theory sounds like it could be possible but, theres probably a different reason.

What do you mean by never getting a tolerance? Ive never heard of someone doing opiates & never increasing their tolerance.........are you saying its possible?

 

[LesFleursDuMal]

I believe persons who 'abuse' their prescriptions always increase their tolerance over time. And oxycodone seems to (like many opiate derivatives) dull the other senses to a point where a coke or speed high isn't as pronounced. Opiates do effect the DA neurotransmitters to be clear, but to what extent they 'deplete' the 'natural' amount of dopamine, I can not say. I think it has something to do with continued use of any drug, which downregulates the body's need to replinish these neurotransmitters (such as DA). Therefore, upon cessation of a drug, the body is still in this mode until it begins upregulating the body's flow which had previously been disrupted. (rememeber: psychoactives only mimick natural chemicals.)

 

[sir_thizzalot]

Damage/deficiency in the dopamine system is not exclusively what you have (otherwise known as Parkinson's disease). It's a condition that can be more appropriately termed stimulant burnout.

Can this stimulant burnout, cause parkinson's- like effects? Like could it make someone mildly twitchy like someone with parkinsons. I'm curious, as there's what I'm 99% sure is a tweaker in my community that I always see walking around, and he has some parkinson's-like effects like rubbing the pointer finger/thumb, or snapping them randomly. I'm sure parkinsons is a possibility too. Just a random thought.

 

[hematocritter]

Well, it's been a while since I made this post.
I am currently off of oxycontin, but by my last dose I was up to 580mg. I felt it a little bit, but not at all like I used to. That was part of why I stopped using it, too damn pricey to take something just because you don't want to get sick (I figure if it isn't treating pain or getting me high, but still costing money and possibly hurting my health, what the hell am I doing with it?).
At first I hated being off the oxy, I just felt no motivation and no passion towards anything. I started having a lot of drinks after work, taking xanax now and then, using Gabapentin or soma, basically anything to feel different than the state of mind I had from being off of oxy. I was irritable, sad, and felt everything was pointless. It didn't help that a lot of external factors in my life had been going badly too.

I began using coke more than normal (1-2x every 10 days probably), and constantly craved it, even though I didn't feel it that much at all. The physical symptoms were there, but the euphoria was so mild that I again began wondering why I was wasting my health and money for barely any benefit. Remeron helped me sleep and gave me a little better mood, but the sedation really hurt my motivation and made me dread work (I am very busy at work). I was willing to try just about anything to feel better, which has never been my nature. I bought some crystal meth that was of high quality, and it did make me feel really good.... but only for one day. The next day I didn't feel anything pleasurable, just more awake. I was still able to sleep the day I took it.
My friends had loads of pure MDMA, and we all tried some..... every one of them was rolling like crazy, and I experienced ZERO, ZILCH, NOTHING.
On another occasion, someone had Phentermine and offered me one because it was late and I was really tired. I had intense feelings of well being and great energy. She gave me a couple more to take home because she could tell I liked them so much.
The next time I used one, nothing happened at all except appetite suppression. I used another one many months later and got nothing again, not even the appetite suppression. Sleeping was no problem either.

I began smoking my medical cannabis far more frequently, something I only used to do at night to help get to sleep. I like cannabis, but I never smoked in the day because it hurt my motivation. Since I was already lacking that from the opiate withdrawal, and I wanted to feel anything other than my natural feelings, I began smoking earlier and earlier each day, to the point where I felt normal smoking before lunch. I started smoking cigarettes again to ease anxiety (a very unhealthy habit I kicked easily a while back). I dropped them after a couple packs, realizing it was a bad road to go down again.

I wanted energy so badly, but none of my OTC 'pre workout' stimulants or ephedrine did anything anymore. They would raise my heartrate, but wouldn't give energy or any pleasurable feelings. When I was not on drugs at all, I could take a supplement like that or some chocamine and be bouncing off the walls with euphoric energy all day long. I loved it. Now I could take a bunch of them and not even experience the negative effects, they might as well be sugar pills.

I just made a post today about cocaine, I got some yesterday and played around with it today. I feel mild euphoria and good energy, but nothing like I used to.
I guess doing various drugs including OTC stims in high doses for long periods of time just doesn't work for some people after a while.

Maybe its a good thing, I might make me go completely sober since nothing is working anymore, making it all pointless to bother with.

I did see a doctor a while back about adrenal problems. I was told I was producing excessive cortisol, far more than normal. I have read that stimulant abuse can cause this. I didn't understand that because I have known meth addicts that are active balls of energy after using meth daily for years. How do I fry my adrenals from OTC supps while other people can do hard drugs for months on end and still get the effects they desire?

I went in for surgery once and they gave me IV valium to calm me down. It felt nice and cool, but didn't slow me down one bit. I kept talking to the nurses and doctors, and they gave me more meds until I finally went under. I woke up during surgery, groaned in pain, and went back under. The anesthesiologist said I needed way more drugs to be put down than the average patient.

I guess drugs are just not for me. I had a lot of fun with them in my twenties, but I just can't justify using hard drugs in high doses to barely get any benefit from them.
I suppose we are all different, and some people just can't get high.
I'll never forget my first shot of IV coke, it was the most beautiful and amazing experience of my life. I took a long break from it hoping it experience it again, and I never did. No bell ringer, no train station, not even any euphoria beyond what I get from snorting it.

Oh well..... time to get sober. I'm going to finish these few grams of blow and try my best to avoid drugs for good.
I'll probably end up killing myself in a race car or jumping out of a plane trying to get as close as I can to the pleasure I felt from drugs the first few times I used them.