Wow a lot of responses, thanks to everyone for taking the time to do that, I will answer back any of the questions that were asked....
If you don't know this gentleman has posted at least one.....
Thank You
Until he can get into specifics of what may be causing his problem from discussion in other forums, his question is not advanced. Once he thinks what receptor may be ailing him.....
I cant answer that when thats the very answer Im seeking, all Ive been told by specialists that when I overdosed 8 years ago I may have damaged areas in my hypothalamus or preoptic area during the hyperthermia along with the fact that it happened during sexual activity causing further distruption whilst the brain was in an aroused state with certain hormones released like oxytocin, vasopressin, endorphins, but there is uncertainty what receptor would trigger a chemical sensitivity to all drugs.
do you get pain relief before you get hyperthermia?...assumably not nearly in full i would gather.....
All the times Ive been given opioids during painful incidences I've been too overwhelmed by the adverse reactions to notice what happens to the pain. But Im pretty sure its gone, either that or I no longer notice it having to deal with the intensity of the the adverse reactions and hyperthermia which is a lot worse than the actual pain.
Ever used any illegal drugs? Had heat stroke? Hypothermia? Also, what other meds have you taken in the past and what are you taking ?
I used to take drugs every weekend for many years at at Clubs and Raves, mainly so I could dance my ass off, mainly used mdma, meth, crystal meth/ice, mda, lsd, shrooms, and other random party pills and smoked pot the rest of the week. Never had a bad trip or adverse reaction or side effect in those many years until one day I had an overdose resulting in severe hyperthermia. when I went back to use after that I found that I had developed some sort of chemical sensitivity that would cause me to overheat everytime I tried and soon after I was diagnosed with a neurological illness (Autonomic Dysfunction) that was the end of my recreational drug use and the rest is history for me. Now I just take betablockers to manage my blood pressure issues and rapid heart rates that occur due to volume depletion and postural changes. Also trialling pain meds to mange my chronic pain but still having recations to them as you can see by this topic from whatever damage I did 8 years ago.
For you to develop a severe sensitivity to all psychoactive drugs no matter what their mechanism makes me wonder if all of this isn't psychosomatic
I can understand your scepticism, beleieve me its not the first time ive had the psychosomatic theory thrown at me, at first I used to get shitty everytime someone that dosent know me assumed that, but now I can understand why anyone would think that when i claim something as uncommon as this situation. Heck I would probly think the same bout anyone else....
I had to push my neurologist and specialists into sending me to psychiatrists, pyschologists, neuro-psychiatrists just to clear any doubt anyone would have when I knew all along it was not the case and the shrinks confirmed that, if theres one thing I have left its a strong head on my shoulders, even when im having adverse reactions a lot of the time im as calm as calm can be, maybe cause ive had enof fof this shit and im not scared to die in the worst case scenario.
My Immunologist ( allergy specialists has determined that it is not a allergic sense where swelling occurs its more of a pharmocological effects that occurs in the braion causing supression in my vitals and breathing. Often when ive gone to the ER with adverse effects my oxygen levels are lowr than normal indicating a respiratory depression, my heart rate is exteremely low along with my blood pressure, if i was having a panic attack wouldnt my heart rate be higher? and my oxygen levels not effected. Also the Dr's at ER have never heard of anyone with fevers and hyperthermia from being anxious. The duration of the adverse effects seem to last the duration of the drugs effect.
Furthermore the adverse effects only occur at higher doses where the medications starts to show its pain relieveing effects not any lower and I have no clue when using oral liquids what the threshold is until i get there so there is no predispositioned idea and furthermore the dose i have an adverse reaction seems to be the same equalanalgesic range for other opioids which I discovered after. When I get hyperthermia from an adverse reaction I can go outside at night in winter without a top and sit there in the freezing cold for an hour watching the steam rise off me, if it was psychosamatic I should be able to cut down on my heating bills in winter then by simply thinking warm thoughts?
What about the odd coincidence of developing a chemical sensitivity immideately following and overdose which was severe enough to end my years of drug use , like whats up with that....or the reactions I now have to second hand smoke, fumes, alcohol, food preservatives and which I never used to have, or the reactions and overheating I have to my own bodies chemical changes that occur from different modes like sleeping to waking...or the hyperthermia I experince from sexual activity, one of which ended me up in the ER after sex
There are many more reasons I know its not psychsomatic but I dont want this to end up as a journal right,

jokes, its k man no harsh feelings on the journal suggestion.
it is very likely that a moderate amount of the pain you experience is in your head. It would not be a bad idea to consult a physician or psychiatrist. In the meantime,[/URL]
As In the response above Ive seen shrinks, Ive also seen orthopedic surgeon and rheumatologist for my joint deteroration and go to physio once a week, I have actual detereoration and torn cartlige in all my joints some which require surgery. Ive tried neuropathic pain meds like lyrica (pregabalin) and Gabapentin without any relief thats why im trying opioids. Pain relief is more important for me than getting high but sure I wouldnt mind the occasional escape from lifes problems.
psychological respone would be to stay fucking away from drugs... You better listen to your body!- Murphy
Please see comments right above to Trambunox and the response to The Monkey Mantra. Thanks