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I Almost Got High Today, or did I ?

Unlucky

Bluelighter
Joined
Apr 26, 2007
Messages
594
I've been under the impressions that Ive lost the ability to feel any pleasure or high from drugs as it seems to result in hyperthermia and feeling ill instead of any pleasure. Todays trial with oxy allowed me to feel a what I assume may have been a slight high feeling for the first time in 8 years although uncertain, as it was quickly overshadowed by hyperthermia and adverse ill reponses. What sort of changes in the brain might contribute to this response to drugs.





EDITED IN LENGTH AND DETAIL : Due to the comments below....
SECOND EDIT: Ok, I admit my topic title sucks, mods please change to something more apropriate. =D
 
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no kidding. why is this here?

Its here because I have an issue with inability to get high without experiencing hyperthermia and becoming ill, you guys seem to know a lot bout brain receptors and responses to drugs, thought maybe yous could throw some theories out at me.

This is nota topic I can discuss with my specialists or anyone else, as I use pain medication for chronic pain but I beleive Im also entitled to the ocassional bonuses that come with these drugs as a coping mechanism or whatever as I currently havent been able to drink, smoke or get high in any form in past 8 years.

If my topic reads as a journal then I can cut it down
 

No I'd say it was more of a pathopoeia or anacoenosis


...for some self-representation, I guess. Not all ADD.

Thats right I require some self representation in order to try and find some answers for my condition, it seems I wasted 8 years already without a knock on my door from any person saying they will do their best to work out my mysterious illness, if I dont try and help myself no one else is going to.
 
good god. this isn't an advanced question. Ever hear of the health and wellness forum?
 
good god. this isn't an advanced question. Ever hear of the health and wellness forum?

man, you guys really hammered him on this one.. i havent seen threads like this in ADD though... but maybe he just wants to know what are the bio/chemical routes by which somebody can undergo a change in their response/experience of drugs.
 
good god. this isn't an advanced question. Ever hear of the health and wellness forum?

Was that sarcasm? please tell me it was because I actually thought you were one of the smart dudes but just incase you missed the point....

Tell me what health and wellnesss forum can answer the mechanics behind how its possible for someone to who was previosuly able to take all psychoactive substances reacreationally without incidence to suddenly develop a major significant allergic type reaction and hypersensitivity to ALL pyschoactive substances immedeately following a drug overdose ?

If my question isnt as advanced as you claim then tell me how someone with no prior health issues suddenly develop a Neurological illness and "Autonomic Dysfunction" that has them overheating for the next 8 years immideately following a drug overdose.

Explain to me why I constantly overheat everyday which only gets worse everytime I have an adverse reaction to drugs.

Tell me why there is no other cases in literature like mine if its such a common problem that simply belongs in a health and wellness forum. If its such a basic problem why do all the specialist and neurologist I've seen over the years find my case so complex to diagnose and treat?

I obviously made a mistake posting about a complex issue as this in here but to state that this isn't "an advanced question" is simply ridicilious particularly when Im still undiagnosed and untreated due to its complexity.
 
he just wants to know what are the bio/chemical routes by which somebody can undergo a change in their response/experience of drugs.


Wow, someone that actually understands the problem, thanks man, kudos to you for simply reading and comprehending.:)

I started to feel like I was speaking in a different language, is there anymore people like you in this forum or am I doomed ? perhaps I need to explain my condition with a chemistry formula chart....
 
If you don't know this gentleman has posted at least one (off the top of my head) thread in this forum about his condition and received multiple replies from multiple moderators. Not saying that means he can post whatever he wants, but at least historically the moderators have viewed his question as advanced.

So lay off the moderating if you're not a moderator (uhoh internally inconsistent advice! 8o)
 
Until he can get into specifics of what may be causing his problem from discussion in other forums, his question is not advanced. Once he thinks what receptor may be ailing him, he may ask a question about the specific mechanism of that particular receptor that is an ADD question. Generalized questions about your reactions to drugs are never advanced questions.
 
actually it is well specific enough to try to form hypothesis and is an intriguing situation and only those with insight in the area could even stab at a hypothesis making it more than ADD material in that sense

so if anyone has any bright ideas maybe they can lend some insight to this poor guy :\:D;)

i am no expert in the hyperthermic aspects of opioids however you may simply have a unique chemistry that creates a high sensitivity and lack of tolerance to opioid induced hyperthermia that is far greater than that which will engage the 'high' response

do you get pain relief before you get hyperthermia?...assumably not nearly in full i would gather...
and opioids are not that effective for certain types of pain as well of course, so you may want to note the pain condition...
 
Ever used any illegal drugs? Had heat stroke? Hypothermia?

Also, what other meds have you taken in the past and what are you taking now?

Like Lux said, seems like your body chemistry might leave you predisposed to this unless there's an answer elsewhere (like in the ?s above).
 
For you to develop a severe sensitivity to all psychoactive drugs no matter what their mechanism makes me wonder if all of this isn't psychosomatic. Like, you perceive drug effect and have a mental freak out about worries of overdose and respiratory depression. Or, alternatively, if there's some connection by which your hyperthermia and other bizarre "allergic effects" (which aren't allergies at ALL, as I'm sure you know - if they were, you'd be itchy and your throat would close up) could become a learned response much like a dog drooling at the sound of the dinner bell, then all of this makes sense. It's actually the only hypothesis I can come up with given the absolute non-specificity of what drugs provoke this unusual response. Do you think this is possible?

I would say that, given the lack of knowledge from even the best specialists, this topic may dead-end no matter WHERE you put it on Bluelight, though Gaian Planes was right - it wasn't really my place to suggest it was journal material, and I apologize if it seemed like I was minimizing your concerns, Unlucky.
 
I can honestly say I've never seen or heard of anyone who has a condition as extreme as yours. The only thing remotely close only stems from your hyperthermia, and it occurs in an old acquaintance of mine who fried his hypothalamus gland from a nasty case of heat stroke in the Marines. I think it's safe to say however, that this is not the same condition you have, as you would most certainly be dead by now.

Monkey Mantra brings up an interesting point though. Psychosomatic disorder seems much more likely than any drug-related issue, but it might be helpful to know what experiences you've had with this in the past and what drugs you were on at the time, if any.
 
^ Good suggestion, and I did read the singular post describing your history. Sounds like a pretty rough hand you were dealt that definitely suggests psychosomatic disorder (at least in part). While your condition, as you described it, does seem to stem from a physical problem, it is very likely that a moderate amount of the pain you experience is in your head. It would not be a bad idea to consult a physician or psychiatrist. In the meantime, I would say that you need to keep your body as hydrated as possible and work on finding a different outlet for your pain. Take it for what it's worth....

On another note, cutting yourself is no kind of solution to any problem, and that you realize this is great. I remember my friends from high school who used to cut themselves, and the little rows of scars along their legs and shoulders were VERY obvious to anyone withing speaking distance. They became addicted to the rush of cutting as well as the ability it granted them to say, "Look what I did. Look at what I can handle." Not so much an analgesic as it was an attention-grabber.

Also, take a look at this link... who would have thought that Lifetime would have something to say on the topic?
http://www.mylifetime.com/lifestyle/health/health-a-z/malignant-hyperthermia
 
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Am I the only one here that thinks it is an absolutely dumb idea to give someone hints about his drug induced malfunctions when it is OBVIOUS that he doesn't only seek for an explanation but for a way to continue to take drugs ("Todays trial with oxy")?!?!

DAMN IT! Obviously he has done too much in the past (I've read "drug overdose" several times) so why don't you better leave it? I know that people will think of me as being rude but for some folks the best advice is to stay away from drugs. It's that simple...

The only logical explanation that one develops 'severe side-reactions' from all kinds of drugs is a pure psychological one. It is highly improbable to get 'allergies' from such different substances like ethanol, opioids, THC etc. There's just no rational basis for this. Monkey Mantras "learned response"-statement hits it best. And my interpretation of such a strong (!) psychological respone would be to stay fucking away from drugs... You better listen to your body!

Therefore I felt and still feel that the initial comments to this thread were absolutely justified. ...Bluelight...harm reduction...anybody?! :\

- Murphy
 
Wow a lot of responses, thanks to everyone for taking the time to do that, I will answer back any of the questions that were asked....

If you don't know this gentleman has posted at least one.....

Thank You :)

Until he can get into specifics of what may be causing his problem from discussion in other forums, his question is not advanced. Once he thinks what receptor may be ailing him.....

I cant answer that when thats the very answer Im seeking, all Ive been told by specialists that when I overdosed 8 years ago I may have damaged areas in my hypothalamus or preoptic area during the hyperthermia along with the fact that it happened during sexual activity causing further distruption whilst the brain was in an aroused state with certain hormones released like oxytocin, vasopressin, endorphins, but there is uncertainty what receptor would trigger a chemical sensitivity to all drugs.


do you get pain relief before you get hyperthermia?...assumably not nearly in full i would gather.....

All the times Ive been given opioids during painful incidences I've been too overwhelmed by the adverse reactions to notice what happens to the pain. But Im pretty sure its gone, either that or I no longer notice it having to deal with the intensity of the the adverse reactions and hyperthermia which is a lot worse than the actual pain.

Ever used any illegal drugs? Had heat stroke? Hypothermia? Also, what other meds have you taken in the past and what are you taking ?

I used to take drugs every weekend for many years at at Clubs and Raves, mainly so I could dance my ass off, mainly used mdma, meth, crystal meth/ice, mda, lsd, shrooms, and other random party pills and smoked pot the rest of the week. Never had a bad trip or adverse reaction or side effect in those many years until one day I had an overdose resulting in severe hyperthermia. when I went back to use after that I found that I had developed some sort of chemical sensitivity that would cause me to overheat everytime I tried and soon after I was diagnosed with a neurological illness (Autonomic Dysfunction) that was the end of my recreational drug use and the rest is history for me. Now I just take betablockers to manage my blood pressure issues and rapid heart rates that occur due to volume depletion and postural changes. Also trialling pain meds to mange my chronic pain but still having recations to them as you can see by this topic from whatever damage I did 8 years ago.

For you to develop a severe sensitivity to all psychoactive drugs no matter what their mechanism makes me wonder if all of this isn't psychosomatic

I can understand your scepticism, beleieve me its not the first time ive had the psychosomatic theory thrown at me, at first I used to get shitty everytime someone that dosent know me assumed that, but now I can understand why anyone would think that when i claim something as uncommon as this situation. Heck I would probly think the same bout anyone else....

I had to push my neurologist and specialists into sending me to psychiatrists, pyschologists, neuro-psychiatrists just to clear any doubt anyone would have when I knew all along it was not the case and the shrinks confirmed that, if theres one thing I have left its a strong head on my shoulders, even when im having adverse reactions a lot of the time im as calm as calm can be, maybe cause ive had enof fof this shit and im not scared to die in the worst case scenario.

My Immunologist ( allergy specialists has determined that it is not a allergic sense where swelling occurs its more of a pharmocological effects that occurs in the braion causing supression in my vitals and breathing. Often when ive gone to the ER with adverse effects my oxygen levels are lowr than normal indicating a respiratory depression, my heart rate is exteremely low along with my blood pressure, if i was having a panic attack wouldnt my heart rate be higher? and my oxygen levels not effected. Also the Dr's at ER have never heard of anyone with fevers and hyperthermia from being anxious. The duration of the adverse effects seem to last the duration of the drugs effect.

Furthermore the adverse effects only occur at higher doses where the medications starts to show its pain relieveing effects not any lower and I have no clue when using oral liquids what the threshold is until i get there so there is no predispositioned idea and furthermore the dose i have an adverse reaction seems to be the same equalanalgesic range for other opioids which I discovered after. When I get hyperthermia from an adverse reaction I can go outside at night in winter without a top and sit there in the freezing cold for an hour watching the steam rise off me, if it was psychosamatic I should be able to cut down on my heating bills in winter then by simply thinking warm thoughts?

What about the odd coincidence of developing a chemical sensitivity immideately following and overdose which was severe enough to end my years of drug use , like whats up with that....or the reactions I now have to second hand smoke, fumes, alcohol, food preservatives and which I never used to have, or the reactions and overheating I have to my own bodies chemical changes that occur from different modes like sleeping to waking...or the hyperthermia I experince from sexual activity, one of which ended me up in the ER after sex

There are many more reasons I know its not psychsomatic but I dont want this to end up as a journal right, ;) jokes, its k man no harsh feelings on the journal suggestion.

it is very likely that a moderate amount of the pain you experience is in your head. It would not be a bad idea to consult a physician or psychiatrist. In the meantime,[/URL]

As In the response above Ive seen shrinks, Ive also seen orthopedic surgeon and rheumatologist for my joint deteroration and go to physio once a week, I have actual detereoration and torn cartlige in all my joints some which require surgery. Ive tried neuropathic pain meds like lyrica (pregabalin) and Gabapentin without any relief thats why im trying opioids. Pain relief is more important for me than getting high but sure I wouldnt mind the occasional escape from lifes problems.

psychological respone would be to stay fucking away from drugs... You better listen to your body!- Murphy

Please see comments right above to Trambunox and the response to The Monkey Mantra. Thanks
 
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