Opioids Hydromorphone rectal dose vs. Oxy rectal dose?

[qwertythirty30]

As much as I've looked, I haven't been able to find any real information on this. The HM rectal BA is somewhat debated.

How does rectal HM compare to rectal Oxy?

I plug 120mg of oxy in the morning and that gives me a solid buzz. Any more and I start needing a nap.

I have six 8mg Dillys. I want to get the most out of them without IV/IM.

I dont want to have to re dose in order to feel it.

This is my math, can someone verify?
12.5mg oxy IV equals about 1.5mg HM IV.

Since plugging oxy is around 80% BA, 12.5/.8 = 15.6mg

HM plugging BA is around 50%, so 1.5/.5 = 3mg

So HM plug dose times 3 is about the oxy plug dose.

Does that sound right?

If so, plugging 40mg HM should do the trick?

 

[TheLightBringer]

Youre calculating it all wrong. Why are you dividing with a decimal? Thats like multiplying it. This is basic math…

I hope youre trolling. Im sorry if youre not, dont mean to come of as an asshole.

Your 120mg oxy with 80% BA would mean ~96mg enter your bloodstream. (Its lower than 80% by the way) youre wasting oxycodone not taking it orally

Rectal hydromorphone is less bioavaliable than intranasal even. Intranasal is roughly around 52 - 57% allegedly.

Oral HM is stated to be somewhere in the ballpark of 5 - 7 times more potent than oral morphine. So it would be around 3,33 - 4,66 more potent than oxycodone. The oral BA of HM stated in studies is varied I would just start with 1/5th of your dose of oxy and just do the HM intranasally.

So start with 24mg HM intranasal, even that is pretty high. 40mg would be overkill

 

[qwertythirty30]

Youre calculating it all wrong. Why are you dividing with a decimal? Thats like multiplying it. This is basic math…

I hope youre trolling. Im sorry if youre not, dont mean to come of as an asshole.

Your 120mg oxy with 80% BA would mean ~96mg enter your bloodstream. (Its lower than 80% by the way) youre wasting oxycodone not taking it orally

Rectal hydromorphone is less bioavaliable than intranasal even. Intranasal is roughly around 52 - 57% allegedly.

Oral HM is stated to be somewhere in the ballpark of 5 - 7 times more potent than oral morphine. So it would be around 3,33 - 4,66 more potent than oxycodone. The oral BA of HM stated in studies is varied I would just start with 1/5th of your dose of oxy and just do the HM intranasally.

So start with 24mg HM intranasal, even that is pretty high. 40mg would be overkill

It is basic math, you're just not understanding what I was calculating.

Assuming 12.5mg oxy IV equals about 1.5mg HM IV, and oxy rectal has BA 80% and HM rectal has BA 50%

Then 12.5/0.8 = 15.6mg (this means you have to boof 15.6 to get 12.5 in your system)
and 1.5/0.5 = 3mg (so you would need to boof 3mg to get 1.5 in your system)

So the math I'm doing is calculating how much you would have to take in order to get x amount in your system. Thats why I'm dividing.

"Your 120mg oxy with 80% BA would mean ~96mg enter your bloodstream. (Its lower than 80% by the way) youre wasting oxycodone not taking it orally"
This is highly debatable. Many estimates put boofing higher than oral. Back in the day, 80 snorted or chewed did nothing, but boofing got me high.

"So start with 24mg HM intranasal, even that is pretty high. 40mg would be overkill"
This sounds like a smart plan.

 

[TheLightBringer]

It is basic math, you're just not understanding what I was calculating.

Assuming 12.5mg oxy IV equals about 1.5mg HM IV, and oxy rectal has BA 80% and HM rectal has BA 50%

Then 12.5/0.8 = 15.6mg (this means you have to boof 15.6 to get 12.5 in your system)
and 1.5/0.5 = 3mg (so you would need to boof 3mg to get 1.5 in your system)

Haha now I see it, sorry if I came off as a grumpy asshole I thought you were dividing as to calculate how much you were absorbing through boofing when it was the other way around

 

[TheLightBringer]

"Your 120mg oxy with 80% BA would mean ~96mg enter your bloodstream. (Its lower than 80% by the way) youre wasting oxycodone not taking it orally"
This is highly debatable. Many estimates put boofing higher than oral. Back in the day, 80 snorted or chewed did nothing, but boofing got me high.

"So start with 24mg HM intranasal, even that is pretty high. 40mg would be overkill"
This sounds like a smart plan.

True, could be varied from person to person so do what works best for you. Another benefit to oral though is that more will be metabolized into oxymorphone (a whopping 11 - 19% although Ive heard numbers like 10% being thrown around)