Hydrocodone Metabolism

[DroneLore]

Is there anyway to take advantage of the fact that hydrocodone is metabolized into hydromorphone to get more bang for your buck?

 

[laCster]

hydrocodone is not a prodrug as hydro does not rely on its metabolites for its opiate-effects.

2D6 makes up around 2% of the 450 cytochrome family, while 3A4 makes up roughly 75%. you should probably shoot to inhibit 3A4 with tagamet (cimitidine). 100% pure white grapefruit juice works aswell, but results may vary...

 

[Oxide]

Inhibiting the enzymes will increase the duration of the drugs action, it won't increase the subjective effects at all. (i.e. euphoria, the high.) You can use cimetidine or white grapefruit juice to do this, but don't expect miracles.

Not very much hydrocodone is metabolized into hydromorphone IIRC, as laCster said hydrocodone does most of the work itself.

 

[THC2LSD]

I agree that grapefruit juice may potentiate hydrocodone. To increase hydromorphone, you need something that induces CYP2D6, but not other enzymes like CYP3A4 which make weaker norhydocodone. The only thing i can think of is Doriden(glutethimide), it's also a nice sedative by itself. Unfortunately it's been pulled of the market in most nations, and their is little to no clandestine production. You have a better chance of finding Quaalude than Doriden. The combination of codeine and Doriden was called "Doors and fours"

 

[Pilll_head]

CYP2D6 is considered " non-induceable " unlike most P450 enzymes. Your best bet is grapefruit juice (the white not the ruby red stuff) to extend the half life of hydrocodone, although personally I've noticed GFJ has more of an effect on oxycodone than hydrocodone. I usually drink about 12 oz about 1 hr before dosing. But ugh, it tastes awful...

 

[Oxide]

Answered and closed.