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  • BDD Moderators: Keif’ Richards | negrogesic

hydrocodone and kratom cross tolerance

falsifiedhypothesi

falsifiedhypothesi

Bluelight Crew
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Feb 22, 2014
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Detroit MI
I've had a pretty decent kratom habit for the past three months. I've been taking 5-15 grams of kratom a day, usually in two doses, over the past few months with only about 5 days total of not taking it.

Just recently i ran out of kratom and coincidentally my hydro connect hit me up for the first time in a while. I have had 2 days off of kratom and have yet to experience any noticable withdrawal symptoms.

If I take hydro today how much cross tolerance might I expect? My plan is to take 20mg on an empty stomach, but I really hope kratom hasn't caused my tolerance to shoot up. I'd like to add that I've never taken an opioid for the aforementioned length of time before, I've always had a low tolerance.
 
Kratom is definitely not as well studied as the opioids, so finding concrete answers to your question is difficult. From what I understand of Kratom, a lot of it's action in vivo is in some way related to your opioid receptors. I think you can expect a little bit of cross-tolerance between the two.
 
Hello OP,
I have been using Kratom daily for the last 5 weeks.
After approximately 2 weeks of Kratom use I ingested around 40mg of Oxy (only Oxy, without Kratom)
The effects of the Oxy were minimal at best, and given my Oxy tolerance 40mg should have done it's job.
So yes there certainly is cross tolerance.
However, after about 4 weeks of Kratom use. I ingested a smaller dose of Hydro along with my regular Kratom.
The effects were definitely there. I Proceeded to consume more Hydro and more Kratom throughout the day and ended up having an excellent experience.
You have to take the Hydro with Kratom or the Hydro will go to waste.
At least that's my experience, buy everyone is different.
If you don't have any Kratom, I would definitely save the Hydro until you get more.

Coincidently, my old Oxy plug just contacted me. I passed up the Oxy because I'm currently worried about Kratom WD.
I realize 5 weeks of Kratom use (multiple doses daily), is not that bad. But I'm pretty sure that my body has become physically addicted.

Hope this helps, and I would be interested to hear how it works out for you.
 
Full cross-tolerance to the mu activity is to be expected, to just about every other alkaloid in kratom aside from the opioids, not so much. In other words kratom is fully cross-tolerant with hydro but not the other way around, if that makes sense. Being that kratom has such a low ceiling I can still catch a buzz from as little as 40mgs of oxy after years of daily kratom use though.
 
that's dissapointing to hear, I was hoping for only a small amount of cross tolerance. I'm not going to get hydro until at least tomorrow so I've still got time for my tolerance to go down. I also plan on using the hydro once every couple days but I know how well that plan will hold up lol.
 
Daily kratom use has wreaked my tolerance to oxy/hydro. Before it became a daily thing 25mg had me feeling pretty good, now even after taking a couple weeks off 45mg doesn't even get me itchy. :(
 
That's terrible news. I use K every time the month is longer then my scripts. What would be the best way to get tolerance back down so i no 1 has to take Kratom and Hyds both.? Would u suggest a taper?. which one first?. Also how fast of a taper should it be,like how long and how much to drop daily,weekly monthly maybe
? Thanks for the information. I had no idea about needing both when regular scripts come in. Severe saddy face :(
 
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