Opioids hydrocodone and cigarettes

[runner17]

I don't knw if this has been discussed. i used the search engine, and couldn't find anything that talked about the effects of cigarettes on hydrocodone..
if there is somewhere that talks about this, please point me in the right place.
anyways.

i have noticed that back a few years ago before i smoked cigs i would get a really great sense of euphoric from hydrocodone...
well i have started back taking hydrocodone, but now i smoke cigs. i noticed a big decrease in the effects of the pills, not really the pain killing effects,
but the euphoric feeling. no matter how much u take it feels weaker.. so i didn't smoke yesterday or this morning and i took my dose of hydrocodone a few hrs ago,
and the feeling was back like it was before i was smoking. the great well-being feeling euphoric. it was great..%)

so my question is.
What cause this effect on hydrocodone.. is it the nicotine in the cigs or something else?
i heard that nicotine does something to the liver enzymes that deal with hydrocodone, but i have no idea, and was looking for help from yall.

Thanks.

 

[ErgicMergic]

Short term dopamine tolerance? Nicotine releases a good amount of dopamine, some people find cigs quite euphoric.

Taking a nicotine break for a couple of days might have somehow lowered DA tolerance (upregulation, dopamine stores being repleted, etc.).

 

[Secobarbital]

I don't think cigs have any effect on the strength of hydrocodone. I'd figure the decreased euphoria is tolerance. I would say that when you stopped smoking, you got more euphoria b/c you were concentrating on/looking for it. You'd be amazed what an effect your mind can have on the whole process.