I definitely do start feeling a little sick after awhile if I take a lot of Tylenol in the day. Usually I'm fine with my initial dose of 4 or 4.5 (10/325 pills) (1300-1462.5mg Tylenol). But if I take a 2nd dose later in the day, alot of times it definitely gives me a sick feeling, a little nausea and general discomfort feeling, almost like I'm getting a cold. However, this does sometimes happen with the initial dose as well. I think it just depends how much you're throwing at your liver. Cold water extraction is good, gives you a much more pure high, hits you faster, but unfortunately not quite as strong or long-lasting in my experience. Take milk thistle, it helps significantly with your liver health and actually makes me feel a bit less sick if I've taken too much tylenol in any given day. It's really disgusting to see how much tylenol you put into your body by doing a cold water extraction and seeing the chunk of filtered tylenol. The vast majority of that pill is tylenol and fillers. It just doesn't make sense to not perform a CWE. Simply not worth the damage to your body, and I generally prefer the more mellow, pure, less "intoxicating" high.