Prozac and celexa build up in your system for weeks before having effect, so the am pm doesn't really matter here. They're more dangerous to take together, but I'm assuming both are prescribed, so you should talk to your doc about that. I'm guessing it's worth the risk here, as your doctor defiantly knows the danger of taking both and wouldn't prescribe it otherwise. Dexidrine is safe to take with both, no interactions, but it can possibly destabilize your mood which may or my not affect your depression. I've found amphetamines to help with my depression, but that's because they help with several other conditions that result in my depression, so it may not apply to you. If you're only worried about dexedrine and SSRI interactions, you've got nothing to worry about.