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How toxic is Mephedrone?

the come down or WDs are definitely horrendous. Holy shite. I started crying a couple times the first day, over meaningless bullshit, because I was coming down nearing the WD state.
 
penpal said:
is 1 gram snorted throught out the night considerded alot?
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When I was using Mephedrone, 1 gram in a night was pretty much the standard, if not more. Most people I know would consider that to be an average night with the stuff, but we were into it pretty hard. Looking back now, 1 gram in a night seems to be too much if you're concerned with health, keeping your tolerance low, and dealing with comedowns. I'd say 500-750mg in a night would be considered 'moderate' by me.
 
Sentience said:
Is Methylone considered significantly safer and less toxic?

Compared to Mephedrone, on average for most users, is it any less likely to produce anxiety?
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To be honest my two experiences on methylone were much more scary than any of my ~100 experiences on mephedrone. Mephedrone is more toxic only due to the fact users tend to dose multiple times. I personally believe methylone is more psychologically draining for the following days though.
 
Not trying to be a dick, but it really is different for everyone. It isn't physically addictive, so it isn't a question like "how long can you do heroin before WD's?". If you are someone who loves stims, has an addictive personality, and has a lot of mephedrone available when you try it psychological addiction could be near instant.
 
No hoe here. You need to understand that it's a bit of a silly question. It's like asking "how fast is a car?". Even if you got an answer, it wouldn't be useful. I understand what you're wanting to know, and why, but that information doesn't exist.
 
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lagger said:
cant be worse than coke
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its more addictive (than cocaine) in mine and quite few people i have come across's experinces. its THE most addictive drug i have ever tried, pure and simply its brutal and getting away from it is the best thing you can do
 
pofacedhoe said:
its more addictive (than cocaine) in mine and quite few people i have come across's experinces. its THE most addictive drug i have ever tried, pure and simply its brutal and getting away from it is the best thing you can do
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Totally agree. Nothing gripped me so fast, for so long, and took me as far down as Mephedrone.
 
UK cocaine use cut in half during mephedrone boom

Interesting quote from a recent talk by Prof. Nutt:
Mephedrone was banned before we had any proven deaths from it. Most of those reported turned out to be caused by something else. But during the year when it was a popular drug, deaths from cocaine fell by half, saving around 40 lives.
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Source
From all the nasty reports I figured meph was probably more dangerous than cocaine. Perhaps it is more addictive on average, and it does seem to cause even more vasoconstriction than cocaine, and maybe it causes greater bodily harm than cocaine in other ways short of death, but in terms of blunt mortality this finding that cocaine use was cut in half during the UK mephedrone boom and that substituting with mephedrone perhaps aided in saving far more lives than it ended makes mephedrone look like a, ahem, harm reduction drug! I'm not really defending meph, just saying that if this is true for the reasons the Prof. says it would be remiss to ignore it.
 
Well, ive just read another report about a guy being hospitalized with the blue knee thing, something that is common in those reports is that in the hospital they detect normal oxygen levels and everything appears normal wich imo does indicate its not just normalk vasoconstriction being at play here, other stimulants also appear to retrigger those symptons, perhaps due to inflammation.
 
Wikipedia mentions a guy being hospitilized with inflammation on the heart, looks like that is the issue, inflammation, rather then vasoconstriction. There havent been any reports of the start of necrosis with is rather odd (something i have experienced myself, extreme vasoconstriction, turning blue/purple and the start of necrosis in my neck, it cleared up after a few weeks tough, this wasnt related to mephedrone).
 
Sorry for the bad link, and thanks for the correction.

Inflammation is just another symptom of the 'root cause', I think. One of the links posted in the thread I tried to reference suggests the inflammation is an auto-immune response, resulting in vasculitis. Here is a direct link to that source document (I'll test it first): http://www.setox.org/Archivos/Noticias/Mephedrone.pdf

And there is some other supporting evidence in that particular post: http://www.bluelight.ru/vb/showpost.php?p=9276462
 
I'm pretty sure its not just vasoconstriction being at play here.

Yesterday after taking mephedrone i experienced the exact same symptons after i took, 2 gram flephedrone last summer.

- Sudden fatigue and inability to get high, despite taking huge doses of other stimulants
- Rod spots, some sort of rash appearing somewhere
- Rash gets worse and skin looks alot darker

I assume those are the first symptons after wich the blue knee thing can turn up, its not just vasoconstriction but whatcauses this defeats me.
 
Seems that the para substitued ephedrine's cause some sort of inflammation, autoimmume reaction, i would gues there should be case reports of simular things occuring with ephedrine.
 
If sure that this was already mentioned, but 5ht2b agonism is NOT good in a drug that one doses with frequency and intensity similar to how a coke addict approaches coke. MDxx has significant agonism here, but people tend to be marginally sensible dosing them. We should expect mephedrone to too. Along the lines of your hypothesis, maybe this type of cardiac strain, coupled with severe, persisting adrenergic stimulation, could induce some sort of auto-immune feedback loop (it's somewhat plausible, as we'd expect cardiac inflammation from 5ht2b agonism, and para-modified ephedrines should severely fuck with adrenergic function, which mediates this type of allergic response). This line of reasoning remains highly speculative though.

ebola
 
Does 5HT2B agonism cause inflammation acutely? My understanding was that only months of chronic exposure cause fibrosis, and thus likely not behind the adverse reaction we see with mephedrone.

While speculative, the vasoconstriction theory is much more questionable imo, as never there was cardiovascular issues detected in any emergency department and many talk about a "rash" going on too.
 
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