For a first time with 2c-e, I would say go for 12-13mg... I suppose if you are looking for a strong effect... 15-16mg would be better... Although I'd say it isn't worth it to go to high for a substance you have not yet explored. 12-13mg should definitely be enough to experience a good effect. I have had some pretty potent trips at this level. 16mg is where things get pretty mind-fuckish... I ate 22mg recently and that was very strong. I suppose it is all what your into... Some people like to get fucked up and have their mind addled... 12-13mg should be enough to get some visual effects, and have your mind at a real nice place... 16mg confuses the mind a little more, and makes things more dream like, for me at least.
I have never had any nausea problems in particular with 2c-e. Smoke a small amount of weed if you do experience nausea... no more than a hit or 2. 12-13mg should be enough to go explore a bit. It'll be fun walking around, and exploring a construction site... make sure not to be too loud though... you don't want to get in trouble. At this level things get really cool, and you will probably enjoy being exploratory...
In my experience 16mg and more makes me wanna stay at home... because my mind gets all swirly... and it is easier for me not too give a fuck about anything, except my thoughts and some stimulus from my friends... Conversation is always good. Watching movies at the tail-end of the trip (Like 4-6 hours after dosing) is pretty enjoyable... and the drug may stimulate you to be immersed in the film... even if the film is quite boring, you'll probably be excited by it in some ways.
Don't get me wrong I have done 20mg and gone to festivals... but I don't enjoy it as much as i would a dose of acid or 2cb... It muddles my mind too much... and I can't focus on the event taking forth in front of me... Instead I think more about life issues, and how the preceding moments are going to wash over me and bring me to the future... but it is hard for me to stay in the present... a smaller dose around 12mg does not tend to do this.
If you are into glow sticks and stuff.. go for it, throw on some music... liquid dancing will probably give you some joy.
And yeah, i would agree to capsule your dose, and drink it down with some water or juice.
All in all... 2ce is quite strange... Haven't really figured it out yet... I prefer smaller doses with this one... My typical range is 8-16mg... Anything lower is just weird... and anything over that can be sorta weird too, although I'm tripping too hard to really care at that point.
Enjoy and good luck.