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Opioids How to minimize Skin reactions caused by Opioid/Opiate-released Histamine?

As Seroquel has anti histamine based properties would it be effective for this purpose and if not could you advise why?

Thanks in advance
 
Update: the orphenadrine works really nice, has absolutely no sedating qualities but gives a little uplift, potentiation properties are not that massive as with, let's say, DPH, which i found to be a strong potentiator (just like doxylamine).

Hydroxyzine is very sedating (@25mgs), wouldn't even think about taking this during the day (same as with DPH and Doxy), but it goes very well with the opiate buzz. Since the orphenadrine i got (Norflex) is sustained release, it's especially good for long acting opioid substances like tramadol, which i usually take as liquid and sustained release pills to get prolonged effects.
 
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