Yea. Sympathetic nervous system and parasympathetic. Drugs will bind to multiple receptors. @Skorpio
More fundamental than that. 5ht2a agonism decreases the activity of GABA a channels through phosphorylation. As benzos increase GABA a receptor activation when GABA is present, they will directly interfere with the activity of psychadelics (hence why they are fairly effective trip abortificants).
The parasympathetic and sympathetic branches of nervous system are how your brain sends inhibitory and stimulatory signals to muscles/organs/glands, not really germane to the topic.