How powerful synthetic drugs will upend drug markets globally

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How powerful synthetic drugs will upend drug markets globally
By Keith Humphreys
December 2 2014

Keith Humphreys is a professor and director of mental health policy in the Stanford University Department of Psychiatry.

In a 2011 raid, Slovakian police seized over 4 kilograms of a powerful opioid; enough to cause over 2,000 fatal overdoses. But the opioid wasn’t heroin sourced from Afghanistan, Thailand, Iran or some other far away home of the opium poppy. The drug was far more powerful fentanyl, synthesized on the spot.

The Slovakia bust was a dramatic example of a European trend: Illicit drugs made from plants (e.g., cocaine, heroin) are being replaced in some national drug markets by those that are synthesized (e.g., methamphetamine, fentanyl). The U.S. has had a parallel experience in the past decade with the rise of illicit consumption of synthetic opioids and cannabinoids. If illicit drug markets continue to separate from an agricultural base, it would upend traditional understandings of drug markets and drug policy.

Relying on plants grown in far-off locales increases production prices for drug traffickers. Their product is vulnerable to bad weather, blight, wars, eradication efforts and in transit seizures. The speed at which they can produce drugs is captive to the growth cycle of cannabis sativa, coca and the opium poppy and the time required for long-distance transport. When illicit drugs are synthesized in laboratories close to market, all these risks, costs and constraints vanish. The cost-efficiencies of local, synthetic production would allow drug dealers to lower their prices, thus stimulating more use.

Some traditional approaches to drug interdiction would be obsolete in a drug market dominated by synthetic drugs. With drugs being created domestically, there would be little point in spraying Colombian hillsides or chasing down speedboats and airplanes in the Caribbean. On the positive side, the eclipse of international interdiction efforts would ease the understandable resentment of consumer nations among people in drug source and transit countries (e.g., Peru, Afghanistan, Mexico).

Domestic law enforcement would face new challenges in a synthetic-dominated market.

Most obviously, hiding a kitchen sink-based meth lab is much easier than hiding a field of coca plants. Complicating enforcement further, synthetic drugs can be altered at a molecular level by chemists such that they fall outside current legal definitions of prohibited substances. This is in fact already happening with a new, rising class of drugs called either “legal highs” or “new psychoactive substances”.

Law enforcement might be able to reduce synthetic drug supply by controlling precursor chemicals used in drug production. This approach can work -- putting ephedrine-containing cold medicine on prescription wiped out meth labs in Oregon, for example -- but some precursors are available in such bulk and have so many legal uses that controlling them would be daunting.

Given the economic and enforcement-evasion advantage of synthesizing drugs at market rather than creating thousand mile long agricultural production chains, why hasn't this transformation in drug markets happened long ago?

One of the effects of prohibition is to make industries less efficient, including in adopting innovations. When Apple wants customers to abandon old iPhones for the latest model, it conducts a huge press launch with a coordinated marketing campaign and worldwide product rollout. An illegal drug trafficking organization wanting users to supplant, say, cocaine with methamphetamine, has no such options.

Also, drug policy expert Peter Reuter of the University of Maryland points out that established drug users have narrowly defined preferences. “Even with the vast array of psychoactive substances, there is strong loyalty to the tried and true," he says. "Cocaine users in particular show little enthusiasm for trying new stimulants that would seem to provide even better experiences."

Continued here http://www.washingtonpost.com/blogs...hetic-drugs-will-upend-drug-markets-globally/
 
I'm still curious to see if they'll invent a purely synthetic opioid which matches the euphoria induced by natural or semi-natural opiates. So far it hasn't happened, fentanyl (and it's various analogues), methadone and buprenorphine are all better than a kick in the head, but they're nothing compared to the originals.
 
I think it's a 'wait and see' on the black market heroin producing bacteria setups.
 
Now that they are able to use bacteria to produce any opiate they want it wont be long until we start seeing labs of that nature.

Not quite true , as of now they aren't able to fully bio-synthesize opiates. The current research I'm aware of shows that the bacteria require a naturally occurring opiate such as thebane as a feedstock.
Turning one opiate into another is a lot easier than fully bio-synthesizing opiates without the need for a plant derived isoquinoline alkaloidal source, It is only a matter of time though.
 
Methamphetamine is not really a synthetic drug. Although it can be synthesized from scratch, it is easier to use the Chinese grass, ma huang, which contains ephedrine, the most common meth precursor. Thus, meth can be totally synthetic or semi-synthetic depending on the method of synthesis employed in its manufacture. Also, semi-synthetic meth has the advantage of being the dextrotatory isomer, not the racemate as P2P methods produce.
 
Methamphetamine is not really a synthetic drug. Although it can be synthesized from scratch, it is easier to use the Chinese grass, ma huang, which contains ephedrine, the most common meth precursor. Thus, meth can be totally synthetic or semi-synthetic depending on the method of synthesis employed in its manufacture. Also, semi-synthetic meth has the advantage of being the dextrotatory isomer, not the racemate as P2P methods produce.

Most ephedrine isn't sourced from ephedra anymore, but is synthesized from L-PAC. Your point still stands, though, since L-PAC is synthesized through yeast fermentation, and as far as I can tell products that are synthesized from biosynthetic precursors are generally considered semi-synthetic. Though I think you're expecting too much from the Washington Post to care about these technical details!
 
Dresden said:
Methamphetamine is not really a synthetic drug. Although it can be synthesized from scratch, it is easier to use the Chinese grass, ma huang, which contains ephedrine, the most common meth precursor. Thus, meth can be totally synthetic or semi-synthetic depending on the method of synthesis employed in its manufacture. Also, semi-synthetic meth has the advantage of being the dextrotatory isomer, not the racemate as P2P methods produce.

It is because of examples like these that I think the designation "semi-synthetic" tends to be incoherent. I mean, all syntheses derive their precursors from stuff on this planet, right? So how close need the precursor be to the product for said product to be deemed "semi-synthetic"?

ebola
 
It is because of examples like these that I think the designation "semi-synthetic" tends to be incoherent. I mean, all syntheses derive their precursors from stuff on this planet, right? So how close need the precursor be to the product for said product to be deemed "semi-synthetic"?

I think the general rule of thumb is that if the precursors are all petrochemicals, it's synthetic, and if the precursors include compounds harvested from recently-living organisms, it's semi-synthetic. I think this is generally what the terms are used to indicate, not necessarily the actual degree of complexity of the intermediates.
 
Yeah, that's pretty much my thinking as well. My understanding is that semi-synthetic drugs (MDMA, LSD, heroin, and sometimes methamphetamine, depending on synthetic route and precursors employed in its synthesis) are chemically synthesized from organic natural products derived from a living thing--plant, fungus or animal--while synthetic drugs (e.g., ketamine) are never found in nature and wouldn't exist were it not for the invention of the organic chemistry laboratory.
 
My understanding is that semi-synthetic drugs (MDMA, LSD, heroin, and sometimes methamphetamine, depending on synthetic route and precursors employed in its synthesis) are chemically synthesized from organic natural products derived from a living thing--plant, fungus or animal--while synthetic drugs (e.g., ketamine) are never found in nature and wouldn't exist were it not for the invention of the organic chemistry laboratory.

The semi-synthetic drugs wouldn't exist without the organic chemistry laboratory either, nor are they ever found in nature.
 
Yeah, that's pretty much my thinking as well. My understanding is that semi-synthetic drugs (MDMA, LSD, heroin, and sometimes methamphetamine, depending on synthetic route and precursors employed in its synthesis) are chemically synthesized from organic natural products derived from a living thing--plant, fungus or animal--while synthetic drugs (e.g., ketamine) are never found in nature and wouldn't exist were it not for the invention of the organic chemistry laboratory.

My main problem here is that many, many compounds could be potentially synthetic or semi-synthetic, depending on synthetic route used. So this seems like a viable way to categorize syntheses but not compounds. gonna go off the deep-end with pedantry here though: I'll have to note that petrochemicals are roughly as 'natural' as compounds extracted from living things, as the geological forces that formed them out of dead organisms are every bit as 'natural' as those living things. The only valid theoretical pivot I can see is to somehow privilege analysis over synthesis as more 'natural'.

ebola
 
I disagree. If the precursors are not natural products, then the resulting compound will be synthetic regardless of synthetic route. If the precursor chemicals are natural products, the the resulting compound will be semi-synthetic.

For example, methamphetamine: acetylene-->benzene-->benzaldehyde-->PNP-->P2P-->meth (synthetic)
but
ephedrine-->methamphetamine (semi-synthetic)

The deciding factor is the original precursor. Acetylene is synthetic, while ephedrine is a natural product.
 
I disagree. If the precursors are not natural products, then the resulting compound will be synthetic regardless of synthetic route. If the precursor chemicals are natural products, the the resulting compound will be semi-synthetic.

For example, methamphetamine: acetylene-->benzene-->benzaldehyde-->PNP-->P2P-->meth (synthetic)
but
ephedrine-->methamphetamine (semi-synthetic)

The deciding factor is the original precursor. Acetylene is synthetic, while ephedrine is a natural product.

The whole argument is silly - nothing is purely synthetic if you follow the chain of it's creation back far enough.
 
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