I have a moderate tolerance to opioids. 100mg of morphine gives me a nice buzz, but I have to take at least 30-40mg of hydrocodone to feel it. I may be getting some Opana. How much is safe to take at first? How long does it take to kick in? I'm talking oral delivery - I don't do needles and I'm not keen on snorting things either. I certainly don't want to take too much but I want to be able to feel it. Harm reduction and all. How many mg should I start with? Thanks in advance.