I think it depends on how many pills you are doing. The larger the scale, the less careful you have to be, if a little bit of spillage occurs then a few drops lost isn't that big of a deal. But if you're only doing like 4 pills then small errors can mean a lot. I'm not a big fan of CWE because it doesn't give a complete separation, even though it has high solubility in water, some of the hydrocodone will precipitate with the acetaminopen. My personal advice is that if you are only taking 30-40 mg orally then I would probably use about 10 pills, assuming these are 5/325 mg. If you were taking less than that then I wouldn't bother with a CWE because the amount of acetaminophen would probably be safe. The maximum recommended daily dose is about 3000 mg per day
