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How long to wait between MXE and MDMA?

D

dizzai

Greenlighter
Joined
May 30, 2010
Messages
15
Curious about this since it's assumed that mixing MXE with serotonin releasers can be dangerous. I dosed roughly 60mg (pretty high dose for me) of MXE tuesday night, and was hoping to dose some MDMA sunday or monday. Can this be presumed to be relatively safe, or need I wait an extra week?

I realize nobody can give me a definite answer with MXE being so new, but any input is appreciated. Thanks.
 
The drug will be far gone out of your system by then so yes, you should be fine.

Some people have reported bad side-effects and some reported none when these are taken in conjunction.

If it settles your mind, I took roughly 100mg of Methoxetamine about 3 hours after taking 200mg MDMA and I was perfectly fine. In fact it was the most spiritual moment of my short existence in this realm thus far. I know that everybody reacts differently to these mixtures, but even so you're talking about taking them a WHOLE WEEK apart. You'll be fine dude. Have fun:)
 
Your time frame is fine, 4-5 days is plenty time to clear the MXE if you are concerned with the potential for a drug-drug interaction. The only concern is to realize the more frequently you use psychedelics the greater the chances are that you will experience negative after effects like worsened memory, excess sleeping in days following use, etc. hence you should do your best to practice harm reduction, particularly with MDMA use.

I don't know why combining MXE with MDMA in a single night is really any more dangerous than taking either alone though, as long as you don't overdose the drugs or are particularly sensitive to the combination for some reason. I have also combined them in one night and was just fine outside any sort of minor hangover-type effects that pretty much all psychedelics cause.
 
Can someone explain why MXE is dangerous in combination with MDMA? As far as I'm aware, it's safe to mix ketamine and MDMA. I understand that MXE is a dopamine reuptake inhibitor, but what about it makes it dangerous to combine with MDMA?
 
Search, but I'll quote what I wrote in an other post.

Bone14 said:
I would be very cautious with this combo. It is not the same as MDMA/MDA/6-APB + ketamine, methoxetamine is a DARI and a D2 partial agonist. (it most likely has a broad binding profile: NMDA antagonist, mu agonist, sigma agonist, K+ channel blocker, NACh antagonist,, what I'm saying it that it is not easy to predict if this is same to combine with MXE)

Something tells me that methoxetamine's dopaminergic pharmacology might be more similar to PCP than to ketamine. I don't have any data to back it up, because MXE is unstudied, but its just something my instinct tells me. I would honestly be pretty hesitant to combine any of above with MXE because some of the things involve a decent amount of dopamine.

When on MXE, I would stay away from stimulants and MDxx's it just does not seem safe.

I've seen people having insane motoric problems for as long as 20 hours when combining stimulants like methylphenidate and MXE - high doses though, but still, no reason to take the risk. Do not combine.
Click to expand...
 
hmmm... I've combined MXE with the "molly" I have numerous times without any problems. I'm almost positive that this "molly" is bk-MDMA but without testing I can't confirm it.

Also, comparing MXE to ketamine doesn't really make sense. I read somewhere in PD that MXE is actually pharmologically a lot more similar to PCP than ketamine, saying it's a K replacement is more just a marketing tool that RC vendors use
 
Excuse me if i'm wrong, but NONE of the timesframes posted above are based on actual knowledge. No one knows exactly how long MXE is in ones system.
 
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