Just did a quick google search and I'm still not convinced that you can change your blood pH to any noticeable degree. Search the term "changes in blood pH" and correct me if I'm wrong. I would really love for this to be true though.
The real question is if a change in stomach fluid pH will affect Vyvanse due to it being a prodrug.
this isn't totally incorrect imo, its along the right lines.
What im thinking, but not really so much with vyv more with dex and adder is that it is the stomach/urine ph which is variable, not the blood.
The plasma level of the drug in the blood would be influenced by change in stomach/urine ph, however it is not necessarily desirable.
I have tried this, not with vyv, but with the others and it makes for a shorter duration, and a less of a therapeutic effect.
I did not try with vyv because I realized that the stuff is already good enough by itself.
IMO/E sodiumbicarbonate is not effective. I have found a certain type of B12 vitamin to be ok, but I can't be certain if it isn't just placebo effect.
to address your point though, I suspect that since vyv is cleared by the liver, and since that I have thrown it up and still had effects later the day when if i had thrown up dex i wouldn't have, that the key to vyv is your liver. and your heart ofcourse, but liver
so, you need to ask what can affect the liver? well imo other drugs which also work off the liver, however this might not be desirable, but I do see opportunity here to do the opposite of what you asked, I could maybe regulate my vyv better if i used another drug with it which worked from the liver and had desirable contradicting effects. but then again, i dont know. just my 2cents
just saw your contribution GBM, nice. nice. when i have time i will try to look at it, but in the meanwhile if anyone of you who isn't currently occupied doesn't mind summarizing the important points for our purposes your benefiting some# of ppl, thanks