Opioids How Long For Methadone To Absorb And Have Full-Effects On An Empty Stomach An Full.

[Thomas29]

I Usually Take My Methadone on An Empty Stomach But that is Why Effects Can Vary So Much From Factors Such As Food in the Stomach which Not Only will Obviously Inevitably Slow Down the Onset Of Any Orally Ingested Drug But I Read you Can Absorb Methadone as Quick as 15-30-60-120 Minutes Into the Stomach that is Of Course But Methadone Does Not Absorb in the Stomach Unlike Most Orally Consumed Drugs..... But it Only Absorbs in the Intestines, which is Why some say it can take Up to 2 Hours and I usually Take My Dose On an Empty Stomach I am Asking this Question because I Ate One Grapefruit an Hour before My Methadone Drink and then 2 Hours Bit More Roughly I Puked Up whats Seems to be the Grapefruit so I got NO IDEA IF I ABSORBED THE MEATHADONE and just Puked up the Grapefruit or I Puked it ALL UP,


Also I DO NOT FEEL Withdrawal Until 1 Hour And 30 Minutes to 2 Hours for Beginning Effects some people say it Takes 4 Hours for it to Peak then I just Read 6 Hours for the Peak and I Read 7 Hours for the Peak it Me it feels like thats when it is coming Down not peaking Maybe I am just a Rapid Metabolizer LOL! Like Incredibly Fast One If I were hah!


My Source Saying 4 To 6 Hours To Reach Maximum Blood Plasma Levels.

 

[sekio]

It usually takes up to 3-4 hours for oral methadone to peak.

 

[Thomas29]

I Need a 100% Sourced Backed Up Factual Studies Link..... PLEASE GIVE ME YOUR OWN WORDED EXPLANATION, It would be Greatly Beneficial NOT JUST TO ME I Am Always Willing to Share and Let Others Indulge In My Knowledge that is the Words I Speak and Facts that I Can Easily Explain the Plausibility of the Truth Behind How the Concept Works.....


My Question is can it get Stronger After 4 Hours because I Read somewhere it said it could Take 6 Hours to FULLY PEAK And Absorb Completely But I Think I Read somewhere Saying it was as Long as 7 Hours is that True or Not???

 

[sekio]

Orally administered methadone was found to reach peak concentrations between 1.6 and 4.0 hours in 7 healthy volunteers who took it and were monitored for methadone blood concentrations[ref] In another 8 healthy volunteers the average time to maximum plasma concentration after orally administered methadone was 2 hours.[ref2]

There are more references if you search for "methadone tmax". I think 7 hours is overkill to wait.

 

[Thomas29]

PERFECT ANSWER I COULD KISS YOU MWAH! LOL Ok So Good to Know it makes Sense I Usually Notice the Biggest Difference Of Feelings/Effects After 2 Hours and Never Noticed it Stronger By Much After that and 4 Hours Makes Perfect Sense And Is Very Helpful Information To Know when it Comes Time For Me To Dose Before A Certain Occasion to make Sure I Am Fully In Working And Or Thinking Mode For the Upcoming Event.

If Anyone would Like to Back Up OR EVEN DISPUTE with sekio Please Do..... But He Posts A Lot And is Always Comprehensive In His Answers I Have Found His Posts Very Useful while I Am Just Lurking On the Forums And Not Posting.