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  • BDD Moderators: Keif’ Richards

How long for an opiate tolerance to diminish?

D

Downsey

Bluelighter
Joined
Dec 13, 2010
Messages
82
I guess for the past year-year and a half I've been using opiates, mainly oxycodone, anywhere from regular to at least once a week. Only within the past 5 months have i noticed a tolerance build up. In the beginning i remember 15mg had me with sever sweats and nausea...last month 60mgs insufflated would get me feeling pretty nice...now i stopped for around a month and just started again...yet it still takes around 60mg to get to the Nice feeling. I even came across an opana 40mg and killed that within a few hours.

From personal experience, how long did it take your tolerance to simmer down?
 
It's going to take you a while, man, and it will probably never go back down to 15 mg. You're lucky that 60 mg is still doing it for you. There are people posting on this forum who have to take much more than 60 mg to get high.
 
i am a daily user of oxycodone, 30mg's and 15's (rarely, usually 30), for about 1.5-2 years (severe heroin addict for ~4 years, clean off H for ~3.5 years). i didnt take any oxy for 4 days, except taking 100mg's of nucynta in the morning for the 4 days, and took 5-HTP the first 2 days. i just plugged a 30mg roxy tonight, and i got pretty high off the one 30.. slight nod, and just a great opie feeling. my tolerance goes down within a couple days, but for 100% gone, it will be about 1 month, 3 at the most (i was locked up for 3 months for heroin needles, and took 20mg percocet and was fuuucked up. but i have high metabolism, im about 5'7 135 pounds. metabolism has a big role in tolerance depletion and build up ime.
 
ch1nawhite said:
i am a daily user of oxycodone, 30mg's and 15's (rarely, usually 30), for about 1.5-2 years (severe heroin addict for ~4 years, clean off H for ~3.5 years). i didnt take any oxy for 4 days, except taking 100mg's of nucynta in the morning for the 4 days, and took 5-HTP the first 2 days. i just plugged a 30mg roxy tonight, and i got pretty high off the one 30.. slight nod, and just a great opie feeling. my tolerance goes down within a couple days, but for 100% gone, it will be about 1 month, 3 at the most (i was locked up for 3 months for heroin needles, and took 20mg percocet and was fuuucked up. but i have high metabolism, im about 5'7 135 pounds. metabolism has a big role in tolerance depletion and build up ime.
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Maybe thats why my tolerance is so low, because of my high metabolism rate. Im also 5ft 8 & 130 pounds
 
Mine always goes down once I've detoxed. I would use to maintain a constant 'high' and never really tried to see how far I could go - if I had one baf left at bedtime id save it til morning...I would leave some at home and take some with if I left. But my tolerance plummets whenever my DOC has been completely metabolized.
 
True, totally spaced on the fact that weight/size plays a massive roll in dosage. I'm 6'2 210lb.

Here is an interesting question, to maintain a tolerance do you simply need to have an opiate in your system on the daily or does it need to be in your system around the clock, not just administered once?

Stemming from that question, I'm a power lifter and always have been. I have eased up since my microdiscectomy in 2008 (one of the reasons i was introduced to painkillers in the first place) but i still lift heavy weights on the daily. The three main lifts (bench, squat, deads) cause the highest endorphin release out of all the lifts. My next question is exactly how potent of an opiate are endorphins and would they be enough to act on your system in a profound way?

Edit: Then again this question may be irreverent. Finding mixed results on weightlifting vs prolonged workouts for substantial endorphin release
 
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I've never heard of a definitive timeline. Tolerance will increase as long as you take it, and it also develops "memory." By that I mean that if you've developed tolerance before, and managed to lower it by abstaining for long periods of time, once you start using again it'll build up faster than before.

Also, I think you have to consider non physical tolerance. By that I mean that once you've become experienced with opiates, you become accustomed to bigger highs. So even if your tolerance is back to baseline, 15mg won't really feel that good.

That's just my experience and the experience of others that I've talked to.

Here is an interesting question, to maintain a tolerance do you simply need to have an opiate in your system on the daily or does it need to be in your system around the clock, not just administered once?
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Tolerance will build if you dose once a day, or if you dose multiple times a day in order to keep serum amounts level. As long as you're regularly dose, there's no escaping it.


Also, you might want to cut out the opiates if you're lifting. They mask pain, which is an indicator of injuries and they significantly lower testosterone levels, leading to diminished gains.
 
phrozen said:
Also, you might want to cut out the opiates if you're lifting. They mask pain, which is an indicator of injuries and they significantly lower testosterone levels, leading to diminished gains.
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I never lift if I'm on an opiate, my strength plummets when i have an opiate coursing through my veins which makes it pretty much pointless to lift. The testosterone issue was one that originally kept me away from opiates pre-surgery. At that time increasing strength was my only concern while nowadays i just try to maintain.
 
Good topic. I have been wondering the same thing because I know that it would never be as great as when you first hit it but it would be nice to be able to get it back down to a lower amount to get a good feel. I remember the days of just eating a couple of 10mg hydrocodones and feel awesome for most of the night. Now it's over a couple hunderd mg of oxy a day just to get "high". Ah the good ol' cheap high days..
 
You stated you took "anywhere from regular to at least once a week." What does "regular" mean? Once a day? Twice a day? Twice a week?

I've been taking 20mg Hydros about 6-9 times a month since Sept 2010, and so far no signs of tolerance. 20mg still hits me really hard.
 
Regular usage for me would pretty much be all day long. Sometimes i only did them two days out of the week...but when i did, it was/still is an all day event...a fun day of oxycodone would probably be around 120-250mgs depending on what time i started
 
Downsey said:
Regular usage for me would pretty much be all day long. Sometimes i only did them two days out of the week...but when i did, it was/still is an all day event...a fun day of oxycodone would probably be around 120-250mgs depending on what time i started
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Yup....a bit much in my opinion. An all day event gives your system opportunity to adjust to it, and make changes accordingly. Enjoy the high but don't overdo it or you'll be needing more and more just to match that feeling. Pretty soon you're out on the streets buying street heroin.

I'm no doctor but but I would recommend dosing twice a day, two times a week MAX. Any more than that and the addiction monkey is climbing up your back and parking his stinky ass on your shoulders....ewwww!
 
Does methadone curtail an opiate tolerance reset??

I found that after 4 years of being at 15mg for an oxy dose that killed my pain, I started down a bad road of tolerance. I now take 40 to 50mg. I also take methadone. If I take my methadone on time and dont miss a dose, I can handle a break in my oxy use.
I have toyed with the idea of going off the oxy altogether if I can get the benefit of going back to at least 20 mgs for a good dose..

Will the methadone interfere with the tolerance reset? Has anyone had a reset in a month? What is a normal reset period (I know everyone is different...),,, Thanks all!
 
Methadone increases my tolerance to opiates. Let's say if I'm taking 30mg of oxycodone to get high (damn, I wish) and then quit and start taking up to 60mg of Methadone (right before it starts blocking the effects of other opiates) for a few months I'll need twice the amount of oxycodone than I usually need to get high.
 
How long it takes for an opiate tolerance to diminish can vary depending on the type of habit a person has - there are also many other factors, and can even depend just on a person's state of mind and expectations.

I personally binge on oxycodone over a few days, and then take a week or two long break - or sometimes even a month or two. I start at 30 or 45mg twice a day and end up at 60mg twice a day -- always taken orally for the best bioavailability.

I've found that my tolerance can go back down in as little as a week (however, there is also a permanent opiate tolerance I've developed, particularily to oxycodone, and I always need at least 30mg to get high enough); but if you are a daily opiate user and you've been using for a month or longer, it'll probably take longer.

The more you use opiates and the more experience with opiates you have, the faster your tolerance will build up again with a baseline tolerance. It takes me just a few doses of oxycodone to be right back at a 60mg twice a day oxy tolerance.

One thing I've found is that there isn't much of a cross tolerance between hydrocodone and oxycodone -- I am high from 30mg of hydrocodone right now, but I would actually need 45mg of oxycodone to get this same high. However, that being said, I've noticed that oxycodone will block hydrocodone completely if I try taking hydrocodone too soon after taking oxycodone. I need to wait at least 4 days after taking oxycodone in order to get high on hydrocodone, but strangely, I need to wait at least 7-14 days after taking oxycodone to get high on a lower dose of oxy. Hence, I've come to the conclusion that cross-tolerance is incomplete between oxy and hydro, and I take advantage of this to get high on a low dose of hydro (20-50mg) a few days after oxy binges when I would otherwise need 60mg of oxy to get high.

Ever since I used to mess around with hydrocodone as a teenager, my opiate tolerance has never really gone back down to baseline, even after 9+ month long breaks. When I first started using opiates when I was 14, as little as 5mg of hydrocodone or 90mg of codeine would get me high. But eventually I worked my way up to a permanent 20-40mg hydrocodone tolerance that never goes away.

I also feel that methadone has permanently hindered some of the opiate effects for me. I've taken methadone probably less than 25 times in my life, at doses of 20-45mg, but it seems to have taken away from me some of the effects of opiates permanently. I never get a "lovey, empathetic, completely content with life, absolute euphoric" feeling anymore no matter how much I take. Even if I were to take a shitload of oxy or hydro, I'd end up having a mild overdose and start shivering and feeling dysphoria before I ever reach that "lovey empathetic absolute euphoria" feeling again.

Realize that opiate tolerance can be largely psychological -- sometimes, taking a high dose can actually decrease euphoria, because you've actually taken too much and are having a mild overdose, and your body starts blocking the opiate high, perhaps due to a fight-or-flight response. It also seems like the more you've taken opiates, the more your state of mind can influence the high. If you believe that your dose isn't high enough or your tolerance is too high and think that you won't get high, your mind will make this become a reality. It's a lot of mind over matter.

When I'm coming down off speed and my body is completely in pain, as little as 20mg of hydrocodone can feel amazing. However, if I'm feeling normal, even 50mg of hydrocodone might not get me high.

Also, a lot of SSRI antidepressants will inhibit the enzymes needed to metabolize pro-drug opiates (like hydrocodone or codeine, and to an extent oxycodone) into their centrally active metabolites.

Hope this info was useful to someone; I had to learn all this through years of experience and self-experimentation
 
Hi Everyone, this is my first post! If I do/ask/say something against the rules I apologize in advance...LOL

My post is also regarding tolerance and a schedule I have made for myself that seems to work. My DOC's are Norco 10/325 and 2 mg Xanax bars, and ingested marijuana of all types, brownies, oils, love it all. (Some folks will laugh, but you can VERY effectively plug mj oil and it's fabulous and really strong.) I find that adding my ingested mj products adds mountains of euphoria and synergizes perfectly with my other DOC's and helps to keep tolerance down.

Also especially with the Xanax/plugged MJ mix, I have NO PARANOIA AT ALL JUST A BLISSFULL FEELING! I watch Judge Judy on my DVR and think to myself.... "this is what heaven feels like..." (contented sigh..LOL)

I digress... So, of course, like most people, my goal is to use as little of these things as possible, and avoid physical dependency. I've been addicted to alcohol (one year with no alcohol on 10-23-14!!) and I have NO DESIRE to be physically addicted to anything again.


So I have been using as follows:

Day 1: Ingested mj/or plugged mj oil (one hour before other goodies) then 20mg hydrocodone; plugged with 50-75 mg benedryl tablets (done late in the day, around 6 pm, if I do it too early I will re-dose all day long, not a good thing!)8(

Day 2 & 3: are sober days, by "sober" I mean just Mary Jane.... Hey it's not a drug! =D

Day 4: Ingested mj/or plugged mj oil (one hour before other goodies) then 2 mg Xanax....(again, always late in the day or I will certainly re-dose)

Day 5 & 6: 2 more sober days, mj only

Day 7: back to Day 1's Hydrocodone routine. the cycle continues

This way, I put 6 days between use of each addictive substance, but I always have something to look forward to. I would like to hear any comments on what you guys think.

I would absolutely love to have something else to throw in the mix but those are the three that I have access to and that I enjoy. I cannot use uppers for the most part because I have anxiety, I generally need something to relax me.

If I could I would turn 2 of my "sober" days into "Soma" days but I haven't been able to find those lately which is just plaid sad.

Anyway, I have avoided any physical dependency for about 6 months and keeping my costs down using this schedule. Also, I am comfortable using as Much MJ as I want, and I can ALWAYS raise my dose as much as I want and count on it to provide extra euphoria without any worries of overdose.

Thanks!
 
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