How Long Before I Start Feeling Its Effects?

[Mac98]

I picked up some L-5HTP last week and started taking some about 3 days ago (or this is my 3rd day... I think) and I was wondering how long before you start feeling its effects...

And should I take it the day right after a roll? Will it work instantaneously or is it one of those things that take time before you start to feel its effect?

And is it better than Piracetam? Everyone talks about Piracetam like it's key to getting over the MDMA crash...

 

[Bsiren]

Piracetam pre-roll makes a massive difference in the level of pleasure you'll get from MDMA, it also helps minimize come down. 5-htp should not be a pre-loaded supplement, as it can actually diminish the effects of MDMA. It's fantastic as a post- load serotonin regenerator.

Piracetam and 5-htp are two completely different things, so there's no value in comparing their effects. I recommend pre- loading and post loading with piracetam, and an attack dose 4 hours prior seems to be especially beneficial (2 grams or just over is my dose).

 

[socalthizzn]

I picked up some L-5HTP last week and started taking some about 3 days ago (or this is my 3rd day... I think) and I was wondering how long before you start feeling its effects...

And should I take it the day right after a roll? Will it work instantaneously or is it one of those things that take time before you start to feel its effect?

And is it better than Piracetam? Everyone talks about Piracetam like it's key to getting over the MDMA crash...

Piracetam is the key. Ive never noticed much help from 5htp inless coupled with piracetam.
omega3, antioxidants like acai, magnesium i also take. Omega3 is awesome.

 

[Mac98]

So if anything, 5-htp isn't really that great 3 weeks later? Is there anything at all that can help for post-roll depression?

I've been taking Omega3 and Magnesium. I'm not too informed about antioxidants but I guess I can. I'm just trying to find something that'll boost my morale...

 

[Bsiren]

5-htp is likely your best weapon against post-use depression, as it helps regenerate serotonin, and serotonin's depletion is likely most of the cause for depression afterwards.

Piracetam is great afterwards for feeling clear as well as before. Getting as much sleep as possible afterwards helps as well, as this is a natural way of replenishing serotonin. Sunlight is very beneficial too.

 

[mgmt&mdma]

Piracetam pre-roll makes a massive difference in the level of pleasure you'll get from MDMA, it also helps minimize come down. 5-htp should not be a pre-loaded supplement, as it can actually diminish the effects of MDMA. It's fantastic as a post- load serotonin regenerator.

Piracetam and 5-htp are two completely different things, so there's no value in comparing their effects. I recommend pre- loading and post loading with piracetam, and an attack dose 4 hours prior seems to be especially beneficial (2 grams or just over is my dose).

this is probably the best answer IMO.

and whats L-5HTP? i know of L-tryptophan and 5htp. but ive never heard of L-5HTP

 

[Bsiren]

Not sure, I'd look it up- I've only used 5-htp a handful of times post use, and it certainly made a different vs. piracetam alone. Melatonin is a great post use sleep aid as well.

 

[socalthizzn]

sure taking 5htp is going to regenerate serotonin levels. when taking mdma and getting huge rushes of serotonin your brain downregulates the receports that serotonin binds too these are called "5ht1a" receptors. once down regulated these can take anywhere from 3-90 days to start upregulating again. so if you have lots of downregulation then having normal serotonin levels will not help with post roll depression because the serotonin that is being pumped thru your brain has nowhere to bind. this may be why 5htp is not working for you.

 

[mgmt&mdma]

sure taking 5htp is going to regenerate serotonin levels. when taking mdma and getting huge rushes of serotonin your brain downregulates the receports that serotonin binds too these are called "5ht1a" receptors. once down regulated these can take anywhere from 3-90 days to start upregulating again. so if you have lots of downregulation then having normal serotonin levels will not help with post roll depression because the serotonin that is being pumped thru your brain has nowhere to bind. this may be why 5htp is not working for you.

yeah thats a good point. so mixing 5htp with hypericin (st. johns wort) would be a good idea since hypericin upregulates 5ht receptors.

 

[Mac98]

5htp and L-5htp are pretty much the same thing. In fact, I'm sure they ARE the same thing. The treat the same problems and are used for the same reasons. Sorry, I guess I should've specified.

I'll look into Hypericin since I'm in real need of a morale boost right now. My crash was pretty severe and I don't like it at all. I want to start rolling again soon but I'm in no condition to do so even 3 weeks later :s