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How long after taking 5-HTP until I can do DMT?

T

The Smoking Man

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Earlier today at around 1 PM I took 100 mg of 5-HTP, after having drank green tea 40 minutes before. Tomorrow evening I was planning on tripping DMT. However, I don't want all the serotonin getting in the way of the DMT and blunting out the trip. Is 28 hours after taking the 100 mg of 5-HTP long enough, or should I wait another day?
(Physical characteristics, if it matters: 5'11", 109 lbs, 19 years old)
 
I find the "extra serotonin from tryptophan blocking the receptor" thing only seems to have effect when talking about empathogens. Taking 5-HTP or tryptophan before MDMA or methylone will completely blunt it; I have experience with this. I've taken them before tryptamine psychedelics and had no blunting or muting of the experience.

I wouldn't take it before something like a 2C though; I have a feeling serotonin release is part of their action.

Either way; yeah I'd say 28 hours is enough for it to be out of your system.

Don't forget eating a bunch of chicken or drinking a whey shake is putting a bunch of tryptophan in your system so don't consume either of those is you want open serotonin receptors.
 
PepperSocks said:
I find the "extra serotonin from tryptophan blocking the receptor" thing only seems to have effect when talking about empathogens. Taking 5-HTP or tryptophan before MDMA or methylone will completely blunt it; I have experience with this. I've taken them before tryptamine psychedelics and had no blunting or muting of the experience.

I wouldn't take it before something like a 2C though; I have a feeling serotonin release is part of their action.

Either way; yeah I'd say 28 hours is enough for it to be out of your system.

Don't forget eating a bunch of chicken or drinking a whey shake is putting a bunch of tryptophan in your system so don't consume either of those is you want open serotonin receptors.
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I see. I did read a report somewhere else about 50 mg of 5-HTP completely killing someone's ability to hallucinate on DMT and could only feel the body load, but waiting 24 hours after the last dose of 5-HTP solved the problem.
Hmm, I wonder if I'll break through smoking 100 mg... considering my body weight, probably? When I did salvia about a year ago the damn trip lasted 80 minutes (!!!), but that's a kappa-opiod agonist, and I also really don't remember how much of it I smoked, but I don't think it was any sort of ridiculous "heroic" dose.
 
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Not everyone experiences any muting effect whatsoever with 5-HTP; some people continue their preloading right up to their dose of MDMA and say it enhances it best if taken on the same day. I preloaded a recent MDMA roll, stopping about 20 hours before dosing (the night before my evening dose). I smoked DMT while rolling and it was certainly plenty active.
 
solistus said:
Not everyone experiences any muting effect whatsoever with 5-HTP; some people continue their preloading right up to their dose of MDMA and say it enhances it best if taken on the same day. I preloaded a recent MDMA roll, stopping about 20 hours before dosing (the night before my evening dose). I smoked DMT while rolling and it was certainly plenty active.
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Interesting.
I wonder how much smoking DMT while candy flipping would make my serotonin receptors cry. Considering the tolerance buildup from DMT is negligable, which suggests receptor downregulation from its use is about nil, might not be too bad, but I'm still not trying to do that without some more careful consideration. Very tempting, though.
 
SWIM had a pretty dreadful, confusing dissociative and disorienting experience with DMT yesterday, after having taken 100mg of 5-HTP approximately 4 hours prior. Not certain that the combination had anything to do with it, but I felt it appropriate to share this. SWIM also blew out a lightbulb that was in the off position in the adjacent room with 3 clearheaded individual witnesses. Very, very strange evening. The time dilation and frustratingly wretched confusion and dark thoughts subsided after about 15 minutes, but it was a hell of a journey back to baseline. SWIM has no recollection of the breakthru part of the trip, but was reportedly laughing and smiling. The only thing SWIM recalls is coming back altered, in a schizophrenic-like state of mind that lasted 20 minutes, afterwords quickly returning to baseline and called his friends to let them know he was back.
 
I don't think it works like that, having excess precursors does not make the serotonin mechanisms use them. Those systems are stabilized and regulared tightly. What it should help with though is preventing early depletion, eventually serotonin releasers will deplete your 'stock' if you use enough of it fast enough but there is faster depletion if you don't take care of the restocking mechanisms.
From what I hear preloading isn't a particularly smart or effective thing to do and post-loading has also proven to be no more than marginally helpful. It's like with vitamins: it's quite redundant if you eat well but they will not fix everything if you don't. They can help fill in the occasional (mild) deficiencies and optimalize all metabolic systems and while that is nice, it doesn't do magic.

About 5-HTP and DMT: I don't think there is that much evidence to say there would be big interaction between them but just to be sure you might wanna put like half a day between them. That is just a wild guess and precaution though. I have never heard about someone's experience that would help us give you proper advice. We should say: We don't know!!!
 
^Have you ever taken 5-HTP? I get light visuals every time I take it, and a very noticable shift in mood/perception. It certainly is decarboxylated in to serotonin in my brain. And I have taken it during times of serotonin 'depletion', and it almost completely mitigates the syndrome within the first day or two. This was especially helpful after coming off of an SNRI cold-turkey. I have used it to replenish after aMT too, and it works a charm.

You need to take it with a decarboxylase inhibitor (such as EGCG - green tea extract) to get the most efficient use out of it. Although 50mg without a decarboxylase inhibitor has always worked for me, it just causes a body load without the inhibitor (and less gets converted).
 
I have only taken 5-HTP and EGCGs separately and I haven't noticed anything like that.

There was a blind small scale but still properly done study by handing out 5-HTP and placebo's to people taking MDMA to try and figure out if there was any significant statistical difference. There was a small difference but not a significant one found.
Also I have heard about people feeling very differently about a MDMA hangover by interpreting it differently, giving it a different place and meaning altogether. This has removed the negative connotation for at least a few people I know.

So sorry, I don't really believe the above means much. ^
 
Solipsis said:
So sorry, I don't really believe the above means much. ^
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Well I don't really care what the blind study said, because it 100% works for me. If I can feel the psychotropic effects of a bolus amount of serotonin being synthesized in my brain, I don't need some faceless study to tell me whether it works or not. Direct experience means infinitely more to me than some "study".

And even if I don't experience an effect from a particular drug/supplement, I'm not going to discount the anecdotal reports of others' direct experiences.

It's the same with Mucuna/L-Dopa with dopamine. That has a huge psychotropic effect too, but I suppose your going to tell me there was some blind study to suggest that it's all placebo. Whatever, all those parkinsons sufferers who switched their meds to Mucuna aren't complaining.
 
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