I treat NBOMes like this, but with a few exceptions. I suppose that the things I view as the safest, such as LSD, miprocin, DiPT, allylescaline or 2C-B I would consider mixing with an N-benzylated phenethylamine, and I have mixed them with one another, but generally it's not a great idea. DOx compounds too, I've tried many mixed but I'd never even consider a DOx alongside an N-benzylated phenethylamine. I once mixed 25C-NBOMe, MDA and a random pressed street xannie that was almost certainly ~4mg of Bromazolam in retrospect, they were SO common in the area and the effects and timelines line up. Regardless, 25C-NBOMe and MDA mixed in a truly magical way, but both of these drugs are known neurotoxins and I can only remorsefully ponder as to what their neurochemical intersection looked like in my brain. The experience was wonderful and permanently healing in many ways, but I suspect I pushed my nervous system a little bit hard that night/morning.
I've yet to encounter 2C-X's that aren't 2C-B, but I have so far found 2C-B to be the most tofu-like out of the 25 or so different psychedelics I've tried. It also seems to have an insane safety profile, I can't find a single death associated with it despite many accidental overdoses, myself included from foolishly eyeballing using a new sniffing straw that was much larger than I was used to. I wonder if other 2C-X compounds are equally as tough as 2C-B, we just left it out on a glass dish in the living room and all the roommates and we were using it, wearing the mountain down into a series of large lines, then divided with a quick slice leaving waves of traces of psychedelic sand on the tray. We just call it the "insufflation tray". Putting it in a mass spectrometer would be a near complete listing of all the things I've ingested for the past 3 years or so, and it often housed piles of 2C-B equivalent to ~2/3 of a fistful of blueberries, and it would last 6 weeks never degrading in potency. Tryptamines like miprocin, mushroom extracts of various kinds, N,N-DMT, and LSD seemed to degrade if left out around light and room temp/humidity. Most other things don't seem to be affected in such a way, but I may just not be noticing it I suppose. I'm shocked people aren't selling 2C-B in the form of gel tabs, at 7.5mg per tab, 750mg in a sheet, lets say somehow it took a full gram that's only an $80 reagent cost. Compared to mass producing sheets of LSD, that's not a bad competitor just since it's SO cheap tp buy in its finished form. Synthetically too, it's only a couple steps away from 4-thiol, 4-chloro, and for some clever people, 4-iodinated analogs of 2C-B/DOB/4C-B/25B-NBXX compounds, based on how you reduce it after a particular intermediate step.