No I meant having an psychosis while on antipsychotics. I had one on february from meth.
Same. I assume the brain works analog to tech - undefined states lead to undefined behaviour and it's possible to catch more than one psychosis at a time. The thought concept of a scale ranging from zero over normal to psychosis is just wrong. Psychosis - normal - psychosis is one step closer but still a dangerous oversimplification, that would need at least three dimensions if you get the imagination.
GABAergics are imo the acute antipsychotics of choice. My gut tells me that clonidine / sympatholythics might be effective too but this is a plain guess. The dopamine hypothesis was a nice theory but it's flawed and too much contradictory facts around. 5ht2a might be another target yet as psychedelics aren't exactly delirants I'm not so sure but as long as it sedates you it's good. Antihistaminergics too, what a coincidence that most antipsychs are H1 antagonists and/or antiadrenergics and these side effects are being heavily exploited.
It's entirely possible that cases exist where a dopamine shutdown indeed helps and perhaps even too much DA is the origin but that DA antags are notoriously useless in treating drug induced psychosis, well, speaks for itself.
My hunch is that antidopaminergics are just dysphorics, anhedonics. They can slow you down and make you care less about compulsory beliefs, or convince you that you're better off obeying the docs this or that way but it's dangerous. Partial agonists sound better, if they help with the symptoms but apparently it's not so relieable so possibly we could leave these dopamine ceptors alone in many cases and stop bothering with dyskinesia.
I'd say it could be possible to develop something like an antiglutamatergic which would calm the consciousness down not unlike dissociative anesthesia but without the transitional phase, this might make an effective 'reboot' for the brain and replace middle age practices like convulsion therapy or haloperidol but I should do my research before guessing wild.
Maybe too there is a certain subtype of high dopamine personality with pronounced antisocial behaviour, causing a statistical bias. I've just seen too many 'remitted' so-called schizos which continued to be super weird but learned how to hide it from authorities and even speculate that it might be a majority.
Last but not least we have metastudies telling that psychosis cases are better off without chronic medication.
but it's a real issue I've experienced both multiple times personally and heard of similar reactions from others while the majority of professionals is completely ignorant about. This has the power to fuck up lifes. It's just hilarious that high status doctorates notoriously fail or refuse to learn from past disasters, and believe there were one-pill-for-all that just cleanse psychosis (hell, it's not even known yet why and when psychosis happens and I'd bet there is no sich thing as 'the psychosis' but xy variants of neural network malfunction, ergo impossible to come up with a general solution). The only such thing which might work is a death cocktail and they're struggling with that too. But they keep intoxicating overdose cases with dopamine antagonists bullshit fearing respiratory depression (it's called emergency room for a reason, isn't it?) That's negligent homicide imo.
