I couldn't imagine taking phenergan with the methadone.lol. Even as high as my opiate tolerance is, phenergan knocks me on my ass ((unless I'm in withdrawal)). But I did take Cimetidine about 30 mins before mu dose this am, and I am surprised as to how much I feel the 50mg they dosed me this am. I didn't feel yesterday's 40mg or Monday's 30mg, so was very pleasantly surprised today lol. I have a 45 min drive each way to the clinic, so timing works out great. I stop for gas/coffee/cimetidine before I leave which allows plenty of time to start working. Then after I dose, by the time I hit my driveway it's starting to kick in.