• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

How detrimental to your health is APAP really?

Geist89

Geist89

Bluelighter
Joined
Oct 10, 2007
Messages
762
Location
Los Alamitos, CA
I've heard that 4g or more can SERIOUSLY fuck your liver up, and I've heard that 4g isn't good for you but still isn't as bad as just a good night of drinks.

How dangerous is it really?
 
Taking 4 grams of APAP isn't going to cause any lasting damage to your liver. It's the people that keep taking that amount or more that have to worry.
 
Its hard to give a quantified answer to that, isn't it?
^ is right. Taking even more than that at once isn't a huge deal. Doing that daily is bad.
Generally, I say if you're taking APAP containing medications (vicodin, etc) on occasion, don't bother with a CWE for ~4g APAP. If you take them daily, or even semi regularly, you really should do a CWE.
 
it probably all depends on your own liver. some people take tons of it daily with no problems, other people take less and get screwed livers. i apologize for the bad posts today, i slammed my hand in a door so typing is difficult.
 
There has never been a documented case of liver failure related to APAP abuse of less than 7.5 grams in one go.

4 grams is like an industry standard, but is by no means gospel. I've heard estimations from Doc's that on a full grown adult tylenol doesn't do damage until about 15 grams.

Not saying tylenol is good for you but it'll take a lot to bring you to hepatitis. But when it does, your liver is fucked and good luck making it to the top of donor list when you tell them you blew out your liver because of too much vic.
 
Geist89 said:
I've heard that 4g or more can SERIOUSLY fuck your liver up, and I've heard that 4g isn't good for you but still isn't as bad as just a good night of drinks.

How dangerous is it really?
Click to expand...

I can honenstly say in my experiences when I was younger and didn't use the CWE (cold water extraction) method, I found anything over 1800 mgs of APAP made my stomach queasy, and I ended up pretty damn naseous or puking. I know that, that little hydrocode/codiene/oxycodone would never get me that ill... so I chalk it up to the APAP and the adverse effects it has when I was stupid enough to take such risks ingesting that much. I mean, is it going to kill you? Probably not. But the fact it's the key element in the pill making me nauseous, and not the opiod content, I can't imagine it being anything but sabotage to your liver/stomach etc. etc. People who abuse asprin in the first place get stomach ulcers and bleed internally... it's no wonder so many people spend the extra hour or so with CWE... I know I do if I have any decent amount.
 
sonnyluv said:
There has never been a documented case of liver failure related to APAP abuse of less than 7.5 grams in one go.

4 grams is like an industry standard, but is by no means gospel. I've heard estimations from Doc's that on a full grown adult tylenol doesn't do damage until about 15 grams.

Not saying tylenol is good for you but it'll take a lot to bring you to hepatitis. But when it does, your liver is fucked and good luck making it to the top of donor list when you tell them you blew out your liver because of too much vic.
Click to expand...

Thank you! I always come out with this but usually I get yelled at for it.

The toxic dose is 200mg/kg in humans over 6 years old. Do the math, a 75 kg person would need 15 grams of APAP to overdose.

http://www.ncbi.nlm.nih.gov/pubmed/16496488
 
I would like to know how alcohol would potentiate liver damage from APAP.


MMMMMmmmmm Hard Liquor and CWE.
 
time traveler said:
I would like to know how alcohol would potentiate liver damage from APAP.


MMMMMmmmmm Hard Liquor and CWE.
Click to expand...

I'm no expert here, but I'll take a guess that... not only is alcohol a diuretic that's harsh on your liver and stomach, apap on these parts of the body is as well. Compounded, making two negatives twice as bad when in conjunction. I might also guess (and again this is a complete guess) that the diuretic qualities of alchol may speed the apap through your liver faster then usual, thus putting extra strain on said liver. Don't take my advice though, I'm just winging it here.
 
It can certainly kill in high concentrations. The exact amount varies naturally, primarily in relation to your liver condition.

I am a Hep-C positive male in good health and 10,000 mgs can kill me.
 
Up until recently, there was a lot of information going around to HCPs advising them of the dangers of combining alcohol and APAP, but recently people's attitudes seem to be changing. This article is interesting

http://www.australianprescriber.com/magazine/27/1/14/5/#qa

Another one of those cases where the jury's out.

OH and PS I had to call the poisons hotline the other day for someone who had taken a dangerous dose of paracetamol, and their advice was any greater than 6 grams in a day - see a doctor/hospital. They are always super cautious, but still thought you may be interested.
 
i was on around 6 grams at a time 2x a day for about 2 -3 1/2 weeks had my liver tested after and my ast and alts were below normal but then again young people metabolize apap better and at the time i was 6'8 and 130 pounds that might have something to do with it.
 
Taking large doses exceeding four grams daily is not approved by the FDA to have beneficial effects on your liver. You can only imagine.

It's not necessarily suggested to even take four grams a day, however- in some cases that permit - it's necessary.
 
Somewhat offtopic: I came across some codeine 12,8mg + 200mg ibuprofen pills. I just took 8 so that puts me at about 100mg of codeine and 1600mg ibuprofen. This is where I should stop, I know, but I saw on a website maximum daily dosages as big as 3+ grams. If I won't feel any discomfort from these 8 pills, could I down 4 more at about T1:30?

(CWE ain't possible atm, I would've gone with that ofc)
 
Bavanai said:
Somewhat offtopic: I came across some codeine 12,8mg + 200mg ibuprofen pills. I just took 8 so that puts me at about 100mg of codeine and 1600mg ibuprofen. This is where I should stop, I know, but I saw on a website maximum daily dosages as big as 3+ grams. If I won't feel any discomfort from these 8 pills, could I down 4 more at about T1:30?

(CWE ain't possible atm, I would've gone with that ofc)
Click to expand...


when i had the flu, i was on prescribed ibuprofen 2 at 800mg each, up to 4 times daily, you will be fine, if you start getting stomach pains though, this could mean a stomach ulcer.
 
Thanks for the answers, it turned out ok, had a bit of nausea which may have been because of the codeine but nothing else.
 
You must log in or register to reply here.
Top