How come grape fruit juice potentiates opiates more then orange juice even though....

[Swimmingdancer]

I know it makes no sense, but I asked is it true. If you type "grapefruit concentrate opiates" on google, the first like 4 links are ancedotes of it being stronger. Then like 2 of people saying its actually the opposite. Then some more saying its true, and the results kind of fall apart after that. I was assuming it had something to do with either the strain of grapefruit used or the parts of the fruit? Idfk, but that's the only kind of used since I read people specifically say use juice bought in store from concentrate. And it worked, though I always end up drinking a whole bottle in about an hour because fuck it why not, it's delicious.

Those are all exactly the same copy-and-pasted from one person who has cited no evidence to back up their dubious claim that from concentrate juice can contain "25%-40% more" of the active compounds. Maybe they just mean it's often easier to find 100% pure grapefruit juice when it's from concentrate and concentrates might be more likely to use the peel - that would increase the levels of these compounds. Grapefruit juice made from the whole fruit including peel does have more, regardless of whether or not it's made from concentrate.

Bergamot is a type of orange, most known for being the source of the oil that flavors "Earl Grey Tea"....I wonder if Bergamot oranges are even more rich in this "naringin"? If so, you can order bergamot oil....I'm pretty sure. Maybe bergamot oranges don't have "bergamottin" or whatever..but if they do, it could be something to think about as a cheap alternative to potentiation that's not grapefruit...the Bergamot orange is a bitter orange....

Bergamot oranges do have bergamottin, look at the name, bergamottin is named after bergamot, because that's where the compound was first discovered I wouldn't advise drinking bergamot essential oil though.

 

[alt 14]

Yeah I was guessing the peel might have something to do with it when I read awhile back it was the bitter compound in juice, but really had nothing to go off of. And there's no reason for me to like investigate why when I know from concentrate works, at least in the amounts I use when I drink it for that reason. I can't say not from concentrate would or wouldn't work as well because I've never used it.

So I guess the jury's out on if it is a rumor or not then?

 

[ldawg616]

\Im talking about vicoden sorry. So Lets say 70mg of vicoden how much should i reduce that by? And I know its not a science but you all are smart and can give me an estimate couldn't you? Should I try 40mg and 8floz of white grape fruit juice?

 

[alt 14]

Well I know probably every single person will disagree with me on this, but I wouldn't reduce the amount of opiates by much or at all. Some people say take half to a third less, but if you can take 70 OR like 90-100 and only get throw up sick, if that, don't reduce it much. But if 70 is at the higher end of your dosing, you'll need to take off more.

Like for me I can feel 40 of hydro, but I could easily take 60 and just be noddy. But I normally go for 40. So I take the whole 40mg, plus like a full bottle of from concentrate white grapefruit juice. About half a bottle before I dose, starting about 45mins to an hour before I plan on taking the pills, and then like another 12oz glass WITH the pills, but usually I end up finishing all 64 ounces by 30mins after the pills went down the hatch. This will work with hydrocodone btw in case you were wondering.


You prob don't need 64ounces to potentiate it, but id say like half the bottle would do it. So like 3-4 z cups would work.

 

[ldawg616]

Well I know probably every single person will disagree with me on this, but I wouldn't reduce the amount of opiates by much or at all. Some people say take half to a third less, but if you can take 70 OR like 90-100 and only get throw up sick, if that, don't reduce it much. But if 70 is at the higher end of your dosing, you'll need to take off more.

Like for me I can feel 40 of hydro, but I could easily take 60 and just be noddy. But I normally go for 40. So I take the whole 40mg, plus like a full bottle of from concentrate white grapefruit juice. About half a bottle before I dose, starting about 45mins to an hour before I plan on taking the pills, and then like another 12oz glass WITH the pills, but usually I end up finishing all 64 ounces by 30mins after the pills went down the hatch. This will work with hydrocodone btw in case you were wondering.


You prob don't need 64ounces to potentiate it, but id say like half the bottle would do it. So like 3-4 z cups would work.

yah that sounds like a lot of liquid. So Im new to grape fruit juice can i drink maybe 3/4 of the bottle 45 min b4 i take pill? Im also taking other things like tagamat naproxem sodium, dxm, cimetidine and atarax

 

[alt 14]

Well if you have Tagamet, the grapefruit juice isn't going to do a whole lot more than an extra cimitedine pill or two would. What's the dxm's main purpose? The dxm works on the same enzyme as the opiates to be broken down iirc, so that may intensify the effects of the dxm and "dirty" the high. Or maybe just make it last longer; I really don't know which. I'd definitely say look into it if you're going to use it so you can know what kind of a dose to do. The hydroxyzine is fine to mix with either gfj of cimitidine, of course.

If you're taking Tagamet instead of or on addition to the grapefruit juice, may I suggest taking a little less hydro? You never menitioned how many pills of that you're taking, but as I understand it, cimitidine blows grapefruit juice out of the water.

 

[ldawg616]

Well if you have Tagamet, the grapefruit juice isn't going to do a whole lot more than an extra cimitedine pill or two would. What's the dxm's main purpose? The dxm works on the same enzyme as the opiates to be broken down iirc, so that may intensify the effects of the dxm and "dirty" the high. Or maybe just make it last longer; I really don't know which. I'd definitely say look into it if you're going to use it so you can know what kind of a dose to do. The hydroxyzine is fine to mix with either gfj of cimitidine, of course.

If you're taking Tagamet instead of or on addition to the grapefruit juice, may I suggest taking a little less hydro? You never menitioned how many pills of that you're taking, but as I understand it, cimitidine blows grapefruit juice out of the water.

usualy 70mg-100mg so are you saying that if i took tagamat with grapefruit juice it will ruin the potentiation or jst make it stronger/last longer?

 

[alt 14]

Hmm well if they're 100mg pills basically what I am saying is you could take 400mg of Tagamet and have it potentiate very effectively, and drink grapefruit juice which is all additive to the effects of the opiate high. Or save yourself a few bucks on the juice and take like 2 extra pills and get about the same out of it as you would by adding grapefruit juice.

The only thing I think may take away from the experience is the dxm, though I've never tried it so I can't attest to what it adds, if anything. Like by this I mean if you take 75mg of dxm and it too will be potentiated by gf juice and/or the Tagamet pills, so you might end up actually feeling some dxm effects. Idk if this will happen, purely conjecture. I just wouldn't want to ruin as pure of a buzz as hydro with shite first plateau dxm effects.

I'd say pop like 3 tagamet and drink up on grapefruit juice if it turns out you like it. It's a good drink. If you would feel 40mg of hydro on their own, I think you'd get more out of it. But like I could take 25mg and put all the adds in I want, and still won't feel the 25mg. But 40plain I could, and potentiated is marginally better yet. I wouldn't potentiate if I was at the higher end of my dose scale which is right around 60. It all depends on what 40 and 70mg feels like to you untouched.

 

[ldawg616]

Hmm well if they're 100mg pills basically what I am saying is you could take 400mg of Tagamet and have it potentiate very effectively, and drink grapefruit juice which is all additive to the effects of the opiate high. Or save yourself a few bucks on the juice and take like 2 extra pills and get about the same out of it as you would by adding grapefruit juice.

The only thing I think may take away from the experience is the dxm, though I've never tried it so I can't attest to what it adds, if anything. Like by this I mean if you take 75mg of dxm and it too will be potentiated by gf juice and/or the Tagamet pills, so you might end up actually feeling some dxm effects. Idk if this will happen, purely conjecture. I just wouldn't want to ruin as pure of a buzz as hydro with shite first plateau dxm effects.

I'd say pop like 3 tagamet and drink up on grapefruit juice if it turns out you like it. It's a good drink. If you would feel 40mg of hydro on their own, I think you'd get more out of it. But like I could take 25mg and put all the adds in I want, and still won't feel the 25mg. But 40plain I could, and potentiated is marginally better yet. I wouldn't potentiate if I was at the higher end of my dose scale which is right around 60. It all depends on what 40 and 70mg feels like to you untouched.

I took 10mg hydroxzine, 600mg of tagamat, 30mgdxm, 40mg vicodin, and some grapefrit jice. Now it usualy takes me 70mg-100mg to get gigh...with this combination with the 40mg vicoden and the other stuf, will i feel anything or have to re-dose?

 

[alt 14]

10mg hydroxyzine? I'm guessing you meant 100? Umm I'd go ahead right now and top up to 100hydroxyzine, or at least 50-75. I've only heard about 25 and 50mg pills, but if they make 10s you'll need more than one.

I'd imagine you need to take at least 10-20 more mg of hydro, but you can wait like 30mins til your hydroxyzine kicks in if you want, unless you particularly like the come-up. If it takes you 100 to be noddy but you can just kind of start to feel it at 60-70, I wouldn't take much less than that tbh.


Good thing is after this first experiment you'll see for yourself how much/little all this stuff helps.

 

[ldawg616]

yah man i dont feel shit....maybe a bery very slight buzz but Im going to have to take more and i meant 100mg and there 50 mg tabs

 

[alt 14]

Don't jump right to your 100mg dose. I'd say another 1/3rd of a tablet would work, but its prob easier to cut it in half. I don't think a half would hurt ya if you can handle 100.

 

[ldawg616]

Well I did and went to 10mg and still brely feel anything...idk why...i always feel them if i take like 70mg idk whats up with me except my high tolerance

Sorry for the double post but if i drink the juice WHILE Im on the vicoden will it make my high longer? Remeeer Im on it

 

[Venrak]

It can, if you still have more enzyme to inhibit, so to speak.

Next time, just edit your last post. I know you wanted a quicker answer, but it didn't seem to make a difference...