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  • BDD Moderators: Keif’ Richards

How come grape fruit juice potentiates opiates more then orange juice even though....

Well I guess the easiest answer is that the potentiation has nothing to do with vitamin c.
 
^ding ding.

It has to do with a chemical inside the grapefruit, but not in oranges, that acts as a substrate for liver enzymes that are responsible for part of the opiod's metabolism.
 
Specifically, the ingredient is narangin, and is only in white grapefruit juice, not in pink or any of your pseudo-juice mixtures.
 
^Cool, thanks for that info.

I didn't know the name of the chemical and didn't quite feel like researching it at the moment. :)
 
synchrojet said:
Specifically, the ingredient is narangin, and is only in white grapefruit juice, not in pink or any of your pseudo-juice mixtures.
Click to expand...

It's spelled naringin, but it's not actually the compound in grapefruit responsible for the potentiation of certain drugs [see this study], nor is it solely found in white grapefruit juice.

The group of compounds responsible for the "grapefruit juice effect", in which the metabolism of certain drugs is affected, are called furanocoumarins. These include bergamottin, bergapten, bergaptol and 6',7'-dihydroxybergamottin. These compounds interfere with enzymes in the body that metabolize drugs. This does not work with all opioids. It depends on how the specific drug is metabolized in the body. Some drugs will be decreased in effect instead of increased.
 
Holy Christ, you're either a genius or a big cheater. Looks it up and copy pastes is the cheater one, btw. Ahahahaa so much knowledge of grapefruit, I hope you get hella fuckin lucky on some sort of gameshow or trivia contest if you knew that off the top of your head. You'd be deserving of the prizes.
 
^^Haha, thanks, I just have an excellent memory for random facts, an interest in this kind of stuff, and read a lot of studies and stuff in my spare time. Those are my own words aside from quickly looking up the exact names of the compounds because bergamottin was the only one I could remember.

But I agree with Venrak, I think it's good to research things (*properly - this does not mean just checking somewhere like Wikipedia and automatically believing it) to make sure one is giving an educated answer.
 
Alright guys thanks for the input. So Lets say it would take me 10mg to get where I need to go but I have an 8 fl oz of white grapefruit juice, how many mg would I have to give up to drink that drink? %mg &mg? 2mg? I hope I'm not breaking rules :(
 
It's my understanding that enzyme inhibition isn't gonna get you higher, it's just gonna keep you high longer because the enzymes aren't breaking down the drugs. Just my understanding I could easily be wrong.
 
^One factor is ROA; if there is extensive first pass metabolism and your dose is oral, there will be a net increase in effects.
 
And what drug? As I said it varies from drug to drug.

But the grapefruit juice effect is notoriously unpredictable, it's not an exact science where we can tell you how many mg of a drug you would need to take with 8 oz of juice (plus different juice is different too). There are so many factors at play. Just err on the side of caution.
 
Why does it have to be white grape fruit juice? Yall gotta problem with the orange man? Anyway it sounds to me like i would have to drink something organic.
 
It doesn't have to be white grapefruit, white grapefruit is just stronger than pink grapefruit. It doesn't have to be organic (although of course organic is healthier, it has nothing to do with the potentiation of drugs). Orange juice doesn't work. You still haven't mentioned what drug you are talking about using it with.
 
Isn't from concentrate grapefruit juice better than organic/non-concentrate? As far as opiate potentiation goes. Or is that a rumor?
 
alt 14 said:
Isn't from concentrate grapefruit juice better than organic/non-concentrate? As far as opiate potentiation goes. Or is that a rumor?
Click to expand...

That makes no sense. Juice "from concentrate" just means that the juice originally had some of the water removed to concentrate it, (to make it smaller and easier to store, freeze, etc), then water is re-added to that concentrate. Maybe they were talking about just drinking concentrate itself? Like you could drink one cup of concentrate to be equivalent to around 4 cups of regular juice I suppose.
 
I know it makes no sense, but I asked is it true. If you type "grapefruit concentrate opiates" on google, the first like 4 links are ancedotes of it being stronger. Then like 2 of people saying its actually the opposite. Then some more saying its true, and the results kind of fall apart after that. I was assuming it had something to do with either the strain of grapefruit used or the parts of the fruit? Idfk, but that's the only kind of used since I read people specifically say use juice bought in store from concentrate. And it worked, though I always end up drinking a whole bottle in about an hour because fuck it why not, it's delicious.
 
Bergamot is a type of orange, most known for being the source of the oil that flavors "Earl Grey Tea"....I wonder if Bergamot oranges are even more rich in this "naringin"? If so, you can order bergamot oil....I'm pretty sure. Maybe bergamot oranges don't have "bergamottin" or whatever..but if they do, it could be something to think about as a cheap alternative to potentiation that's not grapefruit...the Bergamot orange is a bitter orange....
 
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