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How bad is Ecstasy actually for you?

id love to 'fight' you in the sack after splitting a gram of coke! i am being deathly serious *serious face*
 
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i actually put mdma on a similar tolerance line as psychedelics,
you keep dosing and you aint gonna get much higher really,

where as coke and amphetamines you can keep redosing, hell waits for you when you've run out though lol sitting there hung like a gnome
 
I think there's a very interesting point of discussion here.

Just for clarity, in this study the (reported) frequency of MDMA use among "MDMA preferring participants" was a MINIMUM of 0.4 times per month, on AVERAGE 3.3 times per month, and at MAXIMUM 9.6 times per month. Doses (apparently) ranged from 100-600 mg per night and averaged 268 mg.

The participants were screened for anxiety, depression, etc. This suggests that some people were taking MDMA multiple times per month, for years, without suffering major psychological problems. However, the SERT binding potential of those users was substantially reduced- by as much as 56% in the cerebral cortex!

Does reduced SERT binding cause psychiatric disorders? Does it put users at greater risk for them? Does it do anything at all? I'm not really sure. But there's pretty good evidence here that I can AVOID some risk if I put 1-3 months between my rolls, so I'll take that for what it's worth.
 
This suggests that some people were taking MDMA multiple times per month without suffering major psychological problems. However, the SERT binding potential of those users was substantially reduced- by as much as 56% in the cerebral cortex!
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how exactly is this ascertained or tested for? mri type test or blood type screening?
Does it do anything at all?
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good question. how is this practical in real life. theory is all well and good but it needs to be substantiated irl.
 
I only take mdma once or twice a year now but that is more to do with me being older than sensible. In my late 20s I used it every weekend for years as did most of my friends. Most of them are doing very well and living *normal* drug free lives now apart from alcohol, I know two people who ended up in the looney bin for a while but having had in depth conversations with them about their issues it seems that they already had problems that their drug use brought to the surface.

Would they have gone bonkers and needed to be hospitalised if they had never used drugs? Who knows.
 
Clocktower said:
Does reduced SERT binding cause psychiatric disorders? Does it put users at greater risk for them? Does it do anything at all? I'm not really sure. But there's pretty good evidence here that I can AVOID some risk if I put 1-3 months between my rolls, so I'll take that for what it's worth.
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I think that's the best conclusion. The serotonin system heals slowly.

(Ironically the first thing that comes up for a Google of "reduced SERT binding" is the SSRI anti-depressant class! Though, come to think of it, some of the side effects of why I think SSRIs are shit, useful for only very specific situations (a tendency to blunt emotions / make some emotionally numb, brain fog / brain zaps, long term memory issues) are *exactly* some of the things I've seen and read about in some of the more heavy MDMA users...)
 
laugh said:
how exactly is this ascertained or tested for? mri type test or blood type screening?
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The participants underwent PET scans with two different radioactive tracer molecules, one of which was Flourine-18 labeled altanserin, as well as MRI scans. The researchers then compared the results of the "user" scans with the "control" scans.

Essentially how this works is: the altanserin molecules get stuck to the 5-HT2A receptor and emit radiation from their Flourine-18 labels. The scanner measures the amount of radiation coming off of various brain regions- less radiation means less altanserin got stuck, which means fewer 5-HT2A receptors.

EDIT: According to the altanserin page, some studies have found that patients with depression and some other at-risk mental states had decreased SERT binding in certain brain regions. This is correlation, not causation, of course, but it's worth being aware of it.
 
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laugh said:
sounds like a different chemical. tbph it sound like your stuff has been shit house.



yeh ignorance is bliss but i think the pendulum of your conscience has swung too far the other way. i think you are confusing the theory and the prac. you are overhyping the danger imo and you are not saving brains on bluelight. do you wear a mask & cape like zoro? :)
i doubt you would be saying the same thing if you were ingesting pure pharm grade gear.

if dosed in moderation and shown respect it is simply not that bad! ask any old raver. abuse anything and it will fuck you up.

all the tech theory bs is exactly that tech theory bs. practical or first hand knowledge cannot and should not be over ridden by crap read on the net doesn't matter how tech it sounds.
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5/10 For making me laugh about the zoro thing lol

But na mate, it wasn't my stuff. Half of my total rolls were on the old school pokeballs, which only had high amounts of MDMA / caffeine in them tested. I admit i had a few pipes and meth bombs before and i don't count those, i can definitely tell when i've had a dirty pill and yea the come down is 5x worse.
Anyway no i'm not a super hero or anything, i just want people who don't know about rolling to know there can be consequences and fast. I'd like to see as little as possible threads about people asking why they feel fucked up, or are they damaged for life. Because i have been there, and it was hell.
 
^ You have to realize, most people who come on Bluelight do so because they are already hurt.. this is the time they start wondering, what the fuck am I doing to myself?


For every awful comedown thread here, there's 100 if not 1000 people who took the same pills on the same night and are perfectly fine or even had a life changing (for the better) experience. None of those people want to go searching around on the internet about the drug, they just want to take some more in a few weeks. By the time they get to us it's *usually* too late.. the only thing that is going to stop those types of threads from appearing is actual drug education at an early age
 
i too have seen the darker side of mdma effects. took me about a year to get my head back together again. i dont blame the mdma though, i blame my abuse and addictive personality, i thank my parents for those but take responsibility for my own actions. the thing is if i didnt abuse mdma i wouldnt have had the negative issues, the key word is abuse, not mdma. if i didnt fuck myself on mdma it would have been something else, maybe speed (well that was there too), maybe coke, maybe lsd, maybe one of these new fantabulous research chemicals that no one has any long term research on, or it more than likely would have been societies soma legal old ugly and dangerous alcohol.

dont abuse mdma and it will do you no more damage than drinking a bottle of scotch 3 nights a week. a couple drinks in moderation is fine, some even argue is good for you, well i see the same principal applying to mdma. mdma was after all first used in therapy sessions as a tool for positive purposes.

iv always found alcohol comedowns to be just as bad as mdma comedowns..

anyway have a good day! :)
 
is good. you can't abuse mdma, the third consecutive day you use it's like drinking a cup of coffee. other drugs can cause you trouble but not this one.
 
laugh said:
dont abuse mdma and it will do you no more damage than drinking a bottle of scotch 3 nights a week. a couple drinks in moderation is fine, some even argue is good for you, well i see the same principal applying to mdma. mdma was after all first used in therapy sessions as a tool for positive purposes.
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Well... if you drink a bottle of scotch three times a week, you still might be putting some unwanted strain on your body. I guess how much damage is "acceptable" comes down to personal preference, but there's evidence that both alcohol and MDMA can do more-than-negligible damage if used on a weekly basis (for an extended period of time).
 
once i use mdma on friday, on saturday, and then on sunday...about a gram during the sunday...a little crystal about 0,2 g in a bottle of beer...and the rest snorted...and i wasn't high i wasn't rolling...on friday and saturday night i have rolled only snorting molly...this is why i said you can't abuse it...not on a daily basis like all the other drugs except lsd and simil substance mescaline ecc...tolerance prevent me from dependence
 
"Abuse" is not the same as "daily use." One could argue that using MDMA once per week is enough to constitute abuse.
 
farmacista said:
once i use mdma on friday, on saturday, and then on sunday...about a gram during the sunday...a little crystal about 0,2 g in a bottle of beer...and the rest snorted...and i wasn't high i wasn't rolling...on friday and saturday night i have rolled only snorting molly...this is why i said you can't abuse it...not on a daily basis like all the other drugs except lsd and simil substance mescaline ecc...tolerance prevent me from dependence
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i agree with you bro. i also have tried to abuse MDMA and it jus cant be done like other drugs. like YOU said its about 3 days in a row tops then it doesnt matter how many pills you take or molly you snort. you will not roll like the first 3 nights.......not even close. well actually, i guess you could abuse it but it would jus end up being a HUGE waste of MDMA. at the most i would believe some people can roll like 5 days in a row, but anything more than that and i jus cant beleive that.
 
i agree with you about abusing MDMA. it can damage your serotonin system pretty fast. i think that contributes to people "losing the Magic" as they say. im sure if people didnt abuse it and only did it 1 time every 3 months woud probably never hear about people losing the magic because that would probably never happen. i truley believe that rolling multiple days in a row is what causes a lot of the damage to the system. jus my 2 cents.
 
i have rolled every week for some months, lost the magic, take a six months break, try to roll again and...the magic was back! imo it depends from people to people
 
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