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High intake of cholesterol shown to repair damaged brains

asecin

asecin

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Apr 13, 2005
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http://www.naturalnews.com/036258_cholesterol_brain_repair_Alzheimers.html


i think this article makes sense about being good for the brain because of what i read in medical articles online. i believe cholesterol is good for you and the whole bad and good cholesterol thing has no exact definition and separation in between. its mostly how our body processes any cholesterol and considering that we can manufacture it naturally within us without even eating any foods containing it, it definitely has to do with genes, aging and other environmental factors. perhaps adding it from the diet over period of time is not good idea ? maybe too much or too little is both bad ? anyone care to discuss.
 
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LOL..."Good" and "bad" cholesterol are most certainly different. Good and bad cholesterol refers to the transportation system of cholesterin. The molecules which typically carry cholesterin are called Lipoproteins. The most common Lipoproteins are Chylomicrons, VLDL, LDL, IDL, and HDL. Each have specialized proteins that define how they work within the body. HDL and LDL work very differently due to their varying Apolipoproteins. Moreover, the names that they have come from the ratio of TAGs and cholesterin to proteins. Cholesterin is necessary for us to live. It is a crucial part of our cell membranes, allowing them a certain fluidity. Read up on the basics, discussion would be futile until then.
 
Shimmer.Fade said:
LOL..."Good" and "bad" cholesterol are most certainly different. Good and bad cholesterol refers to the transportation system of cholesterin. The molecules which typically carry cholesterin are called Lipoproteins. The most common Lipoproteins are Chylomicrons, VLDL, LDL, IDL, and HDL. Each have specialized proteins that define how they work within the body. HDL and LDL work very differently due to their varying Apolipoproteins. Moreover, the names that they have come from the ratio of TAGs and cholesterin to proteins. Cholesterin is necessary for us to live. It is a crucial part of our cell membranes, allowing them a certain fluidity. Read up on the basics, discussion would be futile until then.
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Through the interaction with the phospholipid fatty acid chains, cholesterol increases membrane packing, which reduces membrane fluidity.[8] In this structural role, cholesterol reduces the permeability of the plasma membrane to neutral solutes,[9] protons, (positive hydrogen ions) and sodium ions.[10]

Actually, no, cholesterol helps to modulate membrane fluidity, so it can either increase or decrease it.
 
Where did I say it only increases cell membrane fluidity? By certain I meant the physiological fluidity at which our cellular membranes normally function..

Sorry I don't just copy and paste.
 
do you think there is some way you can use cholesterol as nootropic ? maybe help stabilize neuron cells fluidity and prevent dementias and other cognitive dysfunctions ?
 
Shimmer.Fade said:
Where did I say it only increases cell membrane fluidity? By certain I meant the physiological fluidity at which our cellular membranes normally function..

Sorry I don't just copy and paste.
Click to expand...

I was talking to myself in that post and corrected (myself). I didn't mean to say you were wrong. Copy and pasting valid information instead of having to go and grab my biochem book ftw!
 
can someone help me out with discussing how can cholesterol be modified in such way that it can actually prevent damaged brains ? perhaps as nootropic ? maybe we should move this to advanced drug discussion forum, they know their chemistry so much better.
 
Cholesterol itself is probably not very neuroactive and no more neuroprotective at the dose levels normally found in food than any other vitamin, mineral, or amino acid is. True, it's an integral part of the cell membrane and required for functioning, but if you eat nothing but steak and fried eggs it is not going to be very good for your cardiovascular system. You also need fatty acid intake to maintin a healthy brain, restricting triglycerides a large amount will make you pretty miserable... Everything in moderation.

Excess cholesterol can lead to gallstones, arterial plaque etc if it is not absorbed properly (it is very poorly soluble in water).

It is also important to note that this article only mentions cholesterol helping a rare genetic defect, and it was in mice... mice aren't exactly known for consuming tons of eggs, meat, and oils. It's not like taking sterol supplements is going to reverse brain damage.

If you want to delve into "modifying" cholesterol then you get into anabloic, androgenic, estrogenic or neurosteroids. Some of them are indeed neuroprotective but they are fairly complex drugs.
 
tnx for this sekio.
was reading few articles on cholesterol lowering drugs and fatigue in people and even degeneration of brain cells. it seems trying to lower cholesterol, remove as much as you can, is detrimental to the body and specifically the brain. i should try to find the article where it says it may cause degenerative problems because of statins, but im chatting from phone and cant search properly. maybe when i have time ill reply back with it.

also, curious about neurosteroids, dont know any such drugs and i wonder if there are good for any cognitive problems and if they are safe ?
 
Neurosteroids and steroids in general are some of the least "safe" drugs you can play with - you can seriously disturb your body's horomone balance. You have to really know what you're doing.

The neurosteroids are very strange drugs that act as a sort of sedative, some of then have been trialed as anesthetics but they have not been studied very far beyond that. I doubt they are "cognitive enhancers" but they may help prevent against e.g. strokes. (There is no evidence for this though)
 
sekio said:
Neurosteroids and steroids in general are some of the least "safe" drugs you can play with - you can seriously disturb your body's horomone balance. You have to really know what you're doing.

The neurosteroids are very strange drugs that act as a sort of sedative, some of then have been trialed as anesthetics but they have not been studied very far beyond that. I doubt they are "cognitive enhancers" but they may help prevent against e.g. strokes. (There is no evidence for this though)
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disturb your hormone balances ? is this perm. sounds like a wet dream tho. i like shit that completely dissembles you and re-wires you again. its exciting, turns you on. just wonder what are popular, good ones to get (easyness of access and such) so i can shut myself in the little room i call world and go wild. =D
 
The neurosteroids aren't "popular" because they are all "research chemicals" sensu stricto. They're only used in cell cultures and are essentially experimental drugs.

Disturbing horomone balances are much less exciting than you expect, do you really want to grow boobs and have your hair fall out? Or become a temeramental, hypersexual anger demon?
 
was wondering, i read cholesterol production within the body is not affected from dietery sources and you dont need precursor to synthesize naturally cholesterol. but cholesterol plays vital role for the cells, and it is mentioned various times that you cant exist without therefore the body synthesize it by itself naturally and with no need of dietery sources. does anyone have any idea how naturally without eating food that contains it cholesterol is manufactured by the body and sent to all the right places ?
 
http://en.wikipedia.org/wiki/Stigmastanol

Stigmastanol (sitostanol) is a phytosterol found in a variety of plant sources. Similar to sterol esters and stanol esters, stigmasterol inhibits the absorption of cholesterol from the diet.[2][3][4] Animal studies suggest that it also inhibits biosynthesis of cholesterol in the liver.[2]

sounds devilish. if it can inhibit the biosynthesis of cholesterol in the liver among healthy people, imagine consequences. it is present in vegetables. hence why men who eat vegetables are not manly.
 
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