madmick19
Bluelight Crew
hey davis you brought up some really interesting points about methadone and of the dangers of using over the top of pharmacotherapies. When people present for opioid dependance to a clinic is is usually because they cannot manage to self moderate their use of substances. and get to a point where they need to use just to feel normal or not go into withdrawal & the difficult experience that is withdrawal.
The Rx pharmacotherapies are usually more potent and have longer half lives than street Opiods, which is great beng that you only have to administer the dose once per day. Also when you have a long acting drug like methadone it gives some of the opioid high while reducing the clients need to use additional opioids. when people go over say 60mg of methadone per day there is a thereputic blockade of the receptor sites (tolerance above that required to feel the effects of street opioids) but each person is different and dose level will change for each person.
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as people feel the need for more of a scripted Phamacotherapy they will in conjunction with the Dr raise the levels over time, in effect driving up tolerance for opioids. ALthough methadone still has an active dose effect curve
this is also the reason using on top of mehadone or using other central nervouse system depressants in combination with MMT can be very dangerous- alcohol, benzodiazapines and opioids potentiate (multiply) each others effects but not in a way that you can accurately control or predict. which puts people at risk of respiritory depression (stopping breathing).
suboxone is a much safer drug for treatment of opioid dependnace due to its features of being a partial agonist. But again everybody is different and between the two drugs methadone and Buprenorphine- they seem to cover most peoples needs for treatment. If you.
The Rx pharmacotherapies are usually more potent and have longer half lives than street Opiods, which is great beng that you only have to administer the dose once per day. Also when you have a long acting drug like methadone it gives some of the opioid high while reducing the clients need to use additional opioids. when people go over say 60mg of methadone per day there is a thereputic blockade of the receptor sites (tolerance above that required to feel the effects of street opioids) but each person is different and dose level will change for each person.
"
Therapeutically appropriate doses of these agonist medications produce cross-tolerance for short-acting opioids such as morphine and heroin, thereby suppressing withdrawal symptoms and opioid craving as a short-acting opioid is eliminated from the body. The dose needed to produce cross-tolerance depends on a patient's level of tolerance for short-acting opioids.
as people feel the need for more of a scripted Phamacotherapy they will in conjunction with the Dr raise the levels over time, in effect driving up tolerance for opioids. ALthough methadone still has an active dose effect curve
this is also the reason using on top of mehadone or using other central nervouse system depressants in combination with MMT can be very dangerous- alcohol, benzodiazapines and opioids potentiate (multiply) each others effects but not in a way that you can accurately control or predict. which puts people at risk of respiritory depression (stopping breathing).
suboxone is a much safer drug for treatment of opioid dependnace due to its features of being a partial agonist. But again everybody is different and between the two drugs methadone and Buprenorphine- they seem to cover most peoples needs for treatment. If you.
