• 🇬🇧󠁿 🇸🇪 🇿🇦 🇮🇪 🇬🇭 🇩🇪 🇪🇺
    European & African
    Drug Discussion

    Welcome Guest!
    Posting Rules Bluelight Rules
  • EADD Moderators: Shambles

here is whats in the coke you did last night

Yeah thats true been dabbling on and off, breaks inbetween, no problems so far, and not addicted to not being sober... i enjoy it. as for going a whole month sober... dont think ive done that since i was 15, and never intend to a month completely sober either
 
Like I said I'm not judging, just handing out a reality check. Today is the first day I've had to myself for almost three months so I'm going to have some coke, roll a spliff and catch the ferry into the city and try and negotiate at the jewellers. It will either be tulips or weeds if you catch my drift
 
One Thousand Words said:
Like I said I'm not judging, just handing out a reality check. Today is the first day I've had to myself for almost three months
Click to expand...

Sooo...that post a couple of weeks back where you were bragging about how hard you worked when you were 17 so that you didn't have to work hard now and had minions running around for you...that was just pure bollocks yes?

I'm not judging...
 
I have every fri-sat off work, but I have adult responsibilities like parenting which kind of cock blocks drug fiending. I had two weeks off over Easter but once again I was playing dad so rather than spliffs and GTA it was skateboarding/rock climbing and multiplayer halo 3.

But today my son has a birthday party after school and my daughter has a tween girl sleep over tonight so they don't need me to pick them up until Saturday morning. With the mrs at work I get a whole day to myself, except we leave for NY/LA next week so I got to get some US dollars and other such mundane shit. Nothing that requires great mental agility though, so I'll be angle to get my dank on, but thanks for your concern SHM
 
inflorescence said:
hmmmm..the seratonin depletion is a worse one for me the dopamine however helps..

"In addition, dopamine appears to influence attention and the ability to concentrate. This is why researchers think that some dopamine-enhancing drugs, such as Ritalin, help control the jittery, unfocused behaviors of attention deficit hyperactivity disorder."
Source psychology today
Click to expand...

Carefully controlled prescription of certain stimulants can ease the symptoms of people with all kinds of disorders, sure. Though you might want to check out the link between dopaminergic drugs and psychosis before stating that 'dopamine helps'.
 
Sammy G said:
Carefully controlled prescription of certain stimulants can ease the symptoms of people with all kinds of disorders, sure. Though you might want to check out the link between dopaminergic drugs and psychosis before stating that 'dopamine helps'.
Click to expand...


I thought he/she was suggesting that dopamine 'helps' as in 'contributes', and was just using the quote as an example of how it can fuck about with your levels of concentration.
 
No, read the post again. :)

She's saying that she thinks dopamine is beneficial ("the dopamine for me however helps"). Why else would she use a quote about the therapeutic use of dopaminergic stims to support it?
 
One Thousand Words said:
I have every fri-sat off work, but I have adult responsibilities like parenting which kind of cock blocks drug fiending. I had two weeks off over Easter but once again I was playing dad so rather than spliffs and GTA it was skateboarding/rock climbing and multiplayer halo 3.
Click to expand...

Get out of it yer big pansy. Going on the above, my mum never had a day off for 20 years, Children are a choice and you chose to give yours your 'me' time

I thought it was only 1 weekend in 4 you had them? ..
 
Looking after kids is a fucking doddle, particularly now they know how to open a fridge and feed themselves. As selfish as I am I'm still responsible enough not to get fucking high and drive the 200km round trip with them in the back. Particularly with 150kg red kangaroos leaping across the road in the pitch dark.

Today is Ferris Beullers Day Off and he plans to be yayo'd at the pub come lunchtime washing down a steak sandwich with a frosty beer, with not need to worry about talking to the principal come 3pm
 
Sammy G said:
No, read the post again. :)

She's saying that she thinks dopamine is beneficial ("the dopamine for me however helps"). Why else would she use a quote about the therapeutic use of dopaminergic stims to support it?
Click to expand...

So what's the 'worse' doing there? Worse than what? It must be bad on some level if that adverb is being bandied about :)
 
She's suggesting that serotonin depletion is a more serious side effect of stimulant use (i.e. 'worse') than the threat of psychosis through excess dopamine.
 
But the discussion was about triggers for psychosis. Serotonin depletion is its own distinct problem. So it's a bit puzzling to declare that it's somehow 'worse' in that context.
 
Sammy G said:
She's suggesting that serotonin depletion is a more serious side effect of stimulant use (i.e. 'worse') than the threat of psychosis through excess dopamine.
Click to expand...

Id sooner have depleted dopermine than psychosis
 
Raising serotonin levels too high can cause psychosis. Psychosis is listed as a side effect in the Physicians Desk Reference for all antidepressants.

The dopamine hypothesis of schizophrenia and psychosis originated from observations of the dopamine-blocking actions of early neuroleptic drugs. These results support the dopamine hypothesis, however, only on the assumption that the drugs act by reversing an underlying disease mechanism (or part of it). An alternative explanation is that the drugs work by inducing a state of neurological suppression that reduces the intensity of symptoms. Although stimulant drugs are known to induce episodes of psychosis, the mechanism for stimulant-induced psychosis has not been clarified, and stimulants are known to affect many neurotransmitters other than dopamine. Recent imaging studies suggest that there may be increased dopamine release in response to amphetamine administration compared to controls. Some studies indicate increased uptake of L-dopa in parts of the striatum, but some do not. The potential confounding effects of factors associated with dopamine release—such as movement, arousal, attention, stress, and smoking—have rarely been examined, and prior medication use may also have influenced results in some studies. Comparable research on other psychiatric conditions associated with increased arousal, stress, and physical activity is sparse. Research on dopamine concentrations in postmortem brain tissue, on homovanillic acid concentrations, and on dopamine receptors has been negative or inconclusive. Therefore, the idea that the symptoms of psychosis or schizophrenia are caused by the overactivity of dopamine is not supported by current evidence.


Read More: http://informahealthcare.com/doi/abs/10.1080/10673220902979896
 
I've had psychotic experiences with a strong emphasis on serotonin excess and also with dopamine excess. Personally I'd say they're both pretty shitty to be honest. The serotonin-based incident was far more intense, vivid and part of a bigger immediate issue at the time so I was a bit distracted with other stuff. The psychosissy bits were flat out nuts but not in the same way dopamine psychosis is. I'm not really sure where you'd draw the line between psychosis and delirium but was probably more the latter for me with serotonin. I've never really taken serotonergics for such extended periods I've hit psychosis in the same way I do with dopamine and it's quite possible it's a rather different beast.

Dopamine psychosis is more like what I'd imagined schizophrenia to be like. Not saying it is actually similar - I don't know if it is or it isn't - but is what I'd picture schizophrenia to be. Lots of paranoia seeing vast conspiracies focussed on you - really very elaborate and bizarre stuff that is almost comical cos it's so much of a cliché but at the time there is no way you could convince me it wasn't real. You really do see the connections everywhere. Everything is connected. All of it relates to you in some way. It's not that I'm thinking I'm especially worthy of being observed and plotted against - it's completely bewildering but you see it so clearly and everything fits but none of it makes sense cos why would these things be happening but they are happening so it has to be true. Even away from the psychosis I'm not always completely sure that all of it was in my head. It does seem so incredibly real however nuts you know it is.

Aside from the conspiratorial stuff there's also visual and auditory hallucinations more real than anything that you'd ever get from psyches. It's really quite disturbing just how real something can appear when it isn't. I guess everything you see and hear is essentially put together in the mind not actually directly observed so if that process goes a bit wonky your mind can do exactly the same thing for stuff that probably isn't anywhere outside my head but damn sure looks and sounds like it is. I find the auditory hallucinations far harder to deal with than the visual ones cos at least I have some sense of visual hallucinations from other drugs so I find those easier to understand even if they do look more real. The aural stuff is just so insanely vivid though and I have nothing to compare that with. You hear it exactly as you would hear anything else - complete with all the real world effects you'd expect of reality. If you are hallucinating something happening outside the sound is muffled by the windows. If it is something coming through speakers it has the hiss and any quirks you're used to with your speakers are also present and correct. Actual voices are the worst by a very long way. They are directly inside your head and they overpower the internal monologue completely. Terrifying doesn't even begin to describe just how scary it is. No matter how you think you would react if such a thing were to happen you won't. All the rest I can cope with to some degree but the voices thing is just a whole other matter. That is not anything I can cope with and hope I don't have to again.

I do still <3 me stims but I think (or I hope) I have finally learnt that a little moderation really does go a long way. There is only so far you can push before things start to crack around the edges and I have no intention of pushing any harder just in case it really does snap and perhaps stay snapped.
 
Have I contradicted myself? Genuine question as...very tired today and probably confusing my thoughts or expressing myself either very badly or in fact just talking bollocks. Ahh the irony is not lost.
 
Hey inflo did u get pm?

Guys I confess o haven't read the last few posts but it seems to me that sammy is right on the money. Dopamine and serotonin arent even the same class of transmitter substance. While chemically they are kissing cousins, the brain uses them in vary different ways. Serotonin is a neuromodulator while dopamine is a neuro transmitter. The difference is that serotonin is more like a hormone. Evolutionary it came first, therefore, all our serotonin is released from the back of rhe brain(cerebullum, pons l etc ). From these areas serotonin is released regularly where it spreads out through the entire brain.

The vital part of the discussion is that serotonin effects how dopamine works, though not vice versa. Dopamine acts by hopping miniscule distances between cells - it's basically how the brain gets shit done when time is of the essence. Meanwhile, whenever dopamine is released across a synapse, the receiving cell will also have a few serotonin molecules already attached to it. Serotonins job is to mitigate the effects of the dopamine. Its kind of like a smoother and more consistent version of GABA. For anyone interested, this whole process I have outlined is called "neural integration".

Quickly, shambles point about serotonin system is an interesting one. I hope someone else can add to this but s good starting point is that a neurochemical would, on its own, be completely useless. It would be like mailing a letter to someone at random instead of someone specific. No, brain chemicals also need addresses. That's what a receptor is for, and as a result the brain has shit loads of different ones. Back in 2000 they had found 16 separate serotonin receptors.

I'm about to pass out - sorry I went on and couldn't wrap up properly.
 
You must log in or register to reply here.
Top