1, Tramadol + Acetaminophen ( both cns acting multimodal painkillers - serotonine release, noradrenaline reuptake inhibition and mu-opioid receptor agonism + endogenous endorphines, endogenous cannabinoids release and ibuprofen works better combined with paracetamol )
2, Ibuprofen ( body and cns inflammation, surprisingly potent pain relief )
3, Dihydrocodeine prolonged release ( sedation and my main mu-opioid receptor agonist )
4, Diazepam ( mental and physical tension treatment )
5, Levetiracetam ( epilepsy treatment )
It's basically sofisticated pain treatment based on many actions which result in reduction in general pain perception mostly by mu-opioid agonism of tramadols metabolite O-Desmethyltramadol and dihydrocodeine + its low concentration dhm metabolite mu-opioid receptor agonism, reduction in inflammation provided by ibuprofen and sligtly by paracetamol and surprisingly tramadol too ( yes, tramadol somehow reduce inflammation ), neuropathic pain decreased by very effective monoaminergic properties of tramadol and its main active metabolite ( tramadol induce higher levels of serotonine, noradrenaline and also of dopamine so both three main monoamines usefull for mostly neuropathic pain relief, instant antidepressant effects, instant reduction in anxiety, hightened motivation and satisfaction from casual tasks - tramadol is absolutely like mild amphetamine with weak opioid affinity but with metabolite capable of full mu-opioid receptor agonism, capability to reach amounts of it binding to receptors that it can be used instead of morphine but with half-life of 6 hours for parent drug and 9 hours for potent active metabolite - for comparison codeine has half-life of 4 hours and morphine of 3 hours.
Dihydrocodeine is stronger version of codeine with slightly longer half-life and it is active drug, no need for rapid cyp2d6 hepatic metabolism. I use it because of effects that don't change if for some reason my liver is slightly less efficiently metabolising through cyp2d6 and i am actually ultrarapid metabolizer but sometimes I can't metabolise enough of tramadol to potent O-DSMT because of enzymatic depletion or maybe inhibition. Also, 12 hours of effects pair nicely with +- 9 hours of effects produced by tramadol and its active metabolite. They compliment each other nicely.
Ibuprofen works for only 4 hours but trust me - it reduce inflammation and it's not as weak for treating pain as everyone things. The problem is not in lack of effects but it will destroy your gut so take it only after eating food. Paracetamol is completely cns acting painkiller with very evident potentiating of opioid, monoamines, antiinflammatory agents induced analgesia.
Diazepam is providing nice muscle relaxation and it reduce fear, anxiety, i would say reducing psychological "pain" it also makes your physical pain less bothering and it provides additional sedation so chances of sleep are higher
Leteriracetam is ( in my case ) 100 % effective at seizure prevention and i also like that it doesn't cause any psyxhological effects. No tired feelings, no enzyme inhibition, it's like taking sugarpill with benefit of doesn't need to worry about having seizure attack.
This is all for today and past week.
