Its possible drugs have fucked me up. I have ibs (bloating, constipation) and food sensitivities. I'm positive my gut microbiome is fucked. It causes me brain fog/headaches and anxiety and difficulty concentrating (I already have this due to ADHD so it exacerbates it) What's worse is a lot of GPs dont have the training to understand the mechanism of how the cognitive issues could arise from ibs. They say it's all in my head. It's my mental health issues, or side effects from all the medications I'm prescribed.
The currently held view is the blood brain barrier means it's not possible for problems in the body to effect the brain. The mind and body are considered separate. Newer research is showing it's possible though. 'The inflamed mind' is a great book that explains how inflammation in the body (whether in the gut, joints as in arthritis, or anywhere else...can cause inflammatory cytokines which can cross the blood brain barrier and cause anxiety, depression etc.
Its wrote by this guy:
https://en.m.wikipedia.org/wiki/Edward_Bullmore
Pretty good credentials if you ask me.
I will never know if chronic codeine usage caused this (stopping my intestine contractions, causing constipation, causing shit which the body wants eliminated to linger/fester in my gut. I could have easily perma messed up my guts ability to contract and expell waste. Apparently this can cause small bacterial overgrowth and a leaky gut/food intolerances. You shouldn't have bacteria in the small intestine, only the large intestine. If bacteria invade the small intestine they can colonize and wreak havoc. Destroying the walls of the intestine, making them leaky and letting large proteins through, when they shouldn't be able to, such as gluten, yeast, any food proteins really. Broken down proteins into amino acids: good. Fully formed proteins: bad. Your immune system can then view these proteins as invaders and attack them, causing chronic inflammation and sensitivities to those food types. I can't eat gluten any more without an intense headache and anxiety a few hours later for example. No I'm not a coeliac. I've been tested twice, the most recent just 6 weeks ago.
Or maybe other drugs such as gbl, loads of booze with sulphates (cheap cider) periods of mdpv abuse, hardly eating at all. Periods of being stoned and having the munchies then eating loads and loads of crap junk food. Chocolate, takeaways, cookies, icecream etc. Literally stuffing myself silly sometimes till I felt ill. My weight was fluctuating all the time back in the day, depending on if I had stims or weed/gbl/booze.
I cant know for sure drugs caused all this but I have my suspicions... Considering all the inconsistencies I threw at my gut, I would hardly have a healthy microbiome, surely? Microbiome is term used for the assortment of good/friendly bacteria in the gut. They have a huge role in food digestion and then creation of certain chemicals the body needs...short-chain fatty acids (SCFAs) such as butyrate
My health right now is pretty bad due to all this. I had a period of 5-6 years clean from drugs recently. These problems started about 3 years ago. Could be a delayed reaction. Opiates can train your gut not to work as efficiently even after stopping. The natural contractions of the migrating motor complex (mmc) normally flush out bacteria in small intestine that shouldn't be there. I hypothesise I may have a faulty mmc that started all my ibs symptoms.
I have to take laxatives daily now, but at least I can take a shit. Sadly the bloating and other cognitive symptoms remain.