• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Has Yohimbine actually worked for anyone?

Tried it years back - mild nasty stim; it's not sexy stuff to my mind but nor is viagra/cialis
 
sekio said:
I'd be willing to experiment with it, although I'd prefer the pharmaceutical yohimbine pills. Yohimbe root is just too difficult to dose, and when the alkaloid is dosed in milligram amounts, I'd rather not risk having my blood pressure set new records.
Click to expand...

Are you referring to a hypothetical situation where these would exist?

Or can one legitimately acquire them?

I'm based in the UK.
If they are for real - would I be looking at health food outlets to source them, or such?
 
Also, is there any information on yohimbine half life, dosing etc?

They seem to be available in 2.5 mg pills - whether these are pharmaceutical grade or not, I don't know?
 
Used it in the form of a standardized extract and then tried pure yohimbine. Certainly not even close to being the same.

Regardless, when I used it for weight control and body building - once I quit I suffered worse fatigue and adrenal issues than after quitting meth.
 
MyExcuse said:
Used it in the form of a standardized extract and then tried pure yohimbine. Certainly not even close to being the same.

Regardless, when I used it for weight control and body building - once I quit I suffered worse fatigue and adrenal issues than after quitting meth.
Click to expand...

Which was better - how did the effects differ?

The dosing seems pretty ambiguous.

20 to 50 mg seems standard, but it's sold primarily in 2.5 mg capsules.


Anyone have an opinion on adding this to a clinical alpha 2 blocker like remeron or mianserin?
 
It depends what you are looking for from it. Personally, I have gotten good results from yohimbine dosed at approx 10mg daily, first thing in the morning for fat loss when doing low carb diets.

As for sexual effects, I would imagine the shakes it causes more than offsets that.
 
The yohimbe version is available in much higher dosing denominations.

I assume thusly the pharmacological version yohimbine is proportionally more potent.

In short - which version is superior??

Edit: And there's also yohimbine and yohimbine HCL....??
 
Last edited:
Have been using Yohimbine HCL powder (cant find the origin paperwork for it but I think it was synthesized one) in small amounts (3-8mg) occasionally as a mild non-aggressive stimulant and did not have any problems with pulse, BP, nor did I notice any chest pains with it, unlike with many classic stims. Combines interestingly with Kratom and some nootropics (especially Centrophenoxine and Aniracetam), but gotta be careful with dosages then. YMMV.:p
 
Okay I got some 2.5 mg yohimbine hcl's in the mail this morning.

Dosed 5 mg to start off.
No feelings one way or the other thus far.

One inhibition I have about it is that, some articles claim it can inhibit CYP2D6 enzyme - which would metabolize other pharmaceuticals I'm on.
The degree to which it does this however - I don't know.

One pubmed article claims it's half life it quite short also - like, less than an hour....?
 
The Charmer said:
It depends what you are looking for from it. Personally, I have gotten good results from yohimbine dosed at approx 10mg daily, first thing in the morning for fat loss when doing low carb diets.

As for sexual effects, I would imagine the shakes it causes more than offsets that.
Click to expand...

When you dosed it in the morning - how long did you notice the effects last for?
 
Oddly - perhaps it was in combo with the other meds but, felt a little more sluggish with the addition of 5 mg yohimbine hcl to 10 mg reboxetine and 30 mg mianserin.

And - it most certainly works as an appetite suppressant in my case.

This unfortunately will be a one and done endeavor.
Last thing I need is an appetite suppressant, or lethargy.

Which means - most/all of my eggs, now go into the Strattera basket.
 
I take Yohimbine HCL sometimes when I don't take my adderall. Coffee is lame to me these days, and I would prefer something stronger but I don't want to waste adderall if I'm not working. So, I just take some of this stuff since I have it in my house. Definitely gets me up and makes me feel kinda tweaked out and even a bit euphoric. However, there's no motivation or anything like amphs give....... just energy and even a bit of a euphoric feeling. At least that is what it does for me, but yeah I like the stuff and definitely stronger than caffeine by a long shot. In my experience, it's nothing bad..... yet nothing good. I live alone, so I don't take it as a sexual enhancer. But as a stimulant, it works in its own way. 100x better than caffeine but no focus/motivation really, just wakes you up and is a bit of a mood lift.
 
I was very surprised when I dosed yohimbe bark tea for the first time...
I've read all the bad reviews, some of them really nightmarish, about panic attacks, crazy heart rate, dizziness, nausea, rage and anxiety...

In my case was nothing like that, more or less the opposite..! Well, few times I had little side effects, a bit of nausea, a bit of headache when took a bit too much, and something that could resemble anxiety (for some people) close to the heart chakra.
I love the adrenergic stimulation it gives, it's potent but if you don't take too much is not difficult to control that energy, I don't get jitters in any way, it's energy is like kratom energy multiplied and more focused, more all-encompassing. I do get an extra motivation, stronger than caffeine motivation and more or less as kratom motivation (when kratom works). I feel that I cannot waste myself physically while on it, I feel like I have infinite energy. It can also help with mental tasks, at least in my case, I can be writing or reading, without distracting so much, more motivated, even if it's more suitable for physical activities.

The pro-sexual effects I think they occur in higher dosages. I remember once I´ve just used it and went to a walk in the street, I saw a girl that was more or less attractive and I thought about how well built she was, in that specific moment (when thinking about it) I felt an enormous libido build up in my genital region, it was almost scary, if I kept thinking about it or looking at her probably I'd had an erection, which rarely happens to me in public spaces... Also, the erections seem better and more "meaty" and orgasms are more powerful, in a way similar to psychedelics, when you are climaxing seconds before the actual orgasming, like edging with the intensity of the orgasm. Increased semen.

I don't use yohimbine nor yohimbe extract but yohimbe BARK. My doses are very little and I think that's the trick: half a teaspoong to a teaspoon and a half. I do think that the tolerance is very important with this plant so you can titrate up after a few days taking it, NEVER start with high dosages or you'll have the typical "toxicodrome" of yohimbe overdosing.

It hasn't a psychological "comedown" for me, you can feel dehydrated and with a bit of headache when coming down but it's better to take first thing in the morning since it can surely affect sleeping patterns and causing insomnia (in my case it affects my sleep but coffee affects me much worse).

Important thing! Most times I used it was along kratom, in fact I think they are the best herbal combo I've ever tried (and I've tried quite a lot), it suits kratom perfectly, it has what kratom lacks and viceversa. I'm pretty sure kratom smooths out yohimbe effects by several ways so read this considering it more like yohimbe + kratom (when having kratom tolerance). Mitragynine can be consider a yohimbane indole alkaloid (as reserpine) and they compliment each other reaaaally good, in my experience.

I hope this would help somebody.
 
some 20 years ago I brought some powdered root bark with me from the Netherlands, tried it and found it’s effects rather nice. Somewhat trippy and a tryptamine like feeling. It also had some pro sexual effects but I didn’t tried it, apart from the usual wank.
 
No, that lazy beggar never worked a day in his life

Typical jungle attitude
 
Interesting how different people react to this compound. I tried a yohimbine pill many years ago, and it was indeed a jittery, anxious nightmare. Unfortunately I forgot the dosage but it was sold in headshops so shouldn't have been overly strong. Clonidine, having the opposite mechanism, is relaxing but also made me feel depressed when used for multiple days in a row. Took me long to figure this out, I was taking the clonidine for sleep based off the belief that it would have the opposite effects of yohimbine which wasn't entirely true.

Wonder if it's indeed a question of dosage? I could certainly use a plant based stim but I'm also very sensitive to norepinephrine, this limits the dosage windows of many stims for me so maybe it's just not for me.
 
plumbus-nine said:
Interesting how different people react to this compound. I tried a yohimbine pill many years ago, and it was indeed a jittery, anxious nightmare. Unfortunately I forgot the dosage but it was sold in headshops so shouldn't have been overly strong. Clonidine, having the opposite mechanism, is relaxing but also made me feel depressed when used for multiple days in a row. Took me long to figure this out, I was taking the clonidine for sleep based off the belief that it would have the opposite effects of yohimbine which wasn't entirely true.

Wonder if it's indeed a question of dosage? I could certainly use a plant based stim but I'm also very sensitive to norepinephrine, this limits the dosage windows of many stims for me so maybe it's just not for me.
Click to expand...
I'm not sure if it has to dowith norepinephrine or other actions, perhaps the specific adenosine receptor stuff..
I react very poorly to other norepinephrine-based stims, specially the human made.
I said in my post that I used bark instead of pure yohimbine and while I've read the opposite idea too, (that the yohimbine itself has less side-effects) I think the bark on its own have some balancing actives on it. I don't know how much yohimbine could be in half a teaspoon of tea bark, but surely not a lot. Perhaps less than 2.5mg?
Also, I suspect that I have ADD, since a long time (in my country was not a trend in any way to diagnose it in the 90s..) so that probably comes in play.
 
Neuroborean said:
I'm not sure if it has to dowith norepinephrine or other actions, perhaps the specific adenosine receptor stuff..
I react very poorly to other norepinephrine-based stims, specially the human made.
I said in my post that I used bark instead of pure yohimbine and while I've read the opposite idea too, (that the yohimbine itself has less side-effects) I think the bark on its own have some balancing actives on it. I don't know how much yohimbine could be in half a teaspoon of tea bark, but surely not a lot. Perhaps less than 2.5mg?
Also, I suspect that I have ADD, since a long time (in my country was not a trend in any way to diagnose it in the 90s..) so that probably comes in play.
Click to expand...
Suspect vs actually having ADHD and non pure vs pure... buy some nutricost Yohimbine 5mg take 2 to try at first I'm 125lbs 2 works for me if you weigh more try more?
 
You must log in or register to reply here.
Top