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has anyone tried dextromethorphan to reduce tolerance?

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onmyway

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Sep 11, 2009
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i have read several threads about using dxm (and other NMDA antagonists) to reduce tolerance to things like opiates and amphetamines, but nothing on cannabis. any experience with this? ideas?
 
For the sake of harm reduction, I say no. Is that the answer I wanna give you?
I'm stoned, pm me and I can give you tons of info about lowering tolerance
 
^lowering tolerance is harm reduction. smoking less would be good, no? i have been noticing a bit of extra congestion which i assume is from all the weed i have been using lately. I would like to cut down on my use for both health and economics.


from what i have read about using dxm for this, i gathered that one takes less than what is considered recreational?
 
Throw in some mucinex then take a break. got dxm and guafinosen to clear out ur dirty lungs.
 
There's actually a scientific neurological explanation on why drugs like shrooms , LSD , dxm etc cand reduce your weed tolerance (it might be temporary . Not sure )

can any more experieced and advanced bluelighters help me with explaining this ?
 
No, it's just mixing drugs. It's called an interaction, it doesn't reduce tolerance it reduces amount needed to reach desired intoxication level. Your tolerance will be the same when the DXM wears off.
 
Lol, by harm reduction I was trying to keep this guy from puking from dxm. Not everybody finds puking from robo pleasant. I sure dislike it, there's easier ways to get messed up
 
DXM isn't going to reduce your tolerance. Just cut back on smoking for a while, it actually doesn't take a really long time for your tolerance to lower considerably. Stop smoking for a week or two. It's not that hard, it's not like you physically can't go without
 
chainer3k said:
No, it's just mixing drugs. It's called an interaction, it doesn't reduce tolerance it reduces amount needed to reach desired intoxication level. Your tolerance will be the same when the DXM wears off.
Click to expand...

i think it has been shown that opiate tolerance is partially dependent on NMDA receptors (which DXM effects). NMDA antagononists can supposedly lessen tolerance to opiates.

i thought somebody must have tried this with cannabis by now.
 
Yes, DXM can help keep opiate tolerance steady, but reducing it, not so much. With cannabis, they do not act on the receptors.

When I was given my first bottle of oxymorphone pills, my doctor prescribed DXM as well to help reduce the speed of tolerance build up.
 
I would doubt it would have any beneficial effect. There is no guarantee that the tolerance mechanisms of the CB receptors are affected by NMDA antagonism in the same way as the opiod and dopamine receptors.

Secondly, the NMDA antagonists are thought to prevent tolerance, not undo it. If you wish to experiment with DXM and cannabis, though, you'll have to lower your tolerance the old-fashioned way first.
 
What I don't understand is how exactly an NMDA receptor antagonist would affect cannabinoid receptors. So I'm thinking that, like dasfa said, the receptor antagonism would simply protect your receptors to prevent the building of tolerance.
 
Backwards... weed brings out dxm. If you take enough dxm for it to do anything, you will NOT get high from your weed, you will trip off the dxm, only.

Smoking weed and taking dxm at the same time brings out the DXM, and covers up the weed. If you're not into crazy ass robotripping along with possible puking, it's not a good idea.
I love dxm, but it's not for everyone, and it will NOT get you high off of the weed.


If you can't get high anymore at all, you need to take a few days break. If it's just taking more to get you high, try smoking out of a bong or something that gets you higher than what a bowl or other piece normally would, if you don't usually use a bong. I hardly ever use a bong, so when I do I get wayyy more high than I normally would.

Hope I helped (: good luck
 
I think its the opposite, I used to trip 24/7 and now I never trip except when I get some good dank cause just 6-8 robo's (absolutely nothing to me at 200 lbs and high tolerance) totaly brings out weed. If you love weed and dxm its a mixture you cant miss for the world.
Yohanson said:
Backwards... weed brings out dxm. If you take enough dxm for it to do anything, you will NOT get high from your weed, you will trip off the dxm, only.

Smoking weed and taking dxm at the same time brings out the DXM, and covers up the weed. If you're not into crazy ass robotripping along with possible puking, it's not a good idea.
I love dxm, but it's not for everyone, and it will NOT get you high off of the weed.


If you can't get high anymore at all, you need to take a few days break. If it's just taking more to get you high, try smoking out of a bong or something that gets you higher than what a bowl or other piece normally would, if you don't usually use a bong. I hardly ever use a bong, so when I do I get wayyy more high than I normally would.

Hope I helped (: good luck
Click to expand...
 
splendide mendax said:
What I don't understand is how exactly an NMDA receptor antagonist would affect cannabinoid receptors. So I'm thinking that, like dasfa said, the receptor antagonism would simply protect your receptors to prevent the building of tolerance.
Click to expand...

i don't think anyone knows exactly what is going on, but NMDA receptors are needed for synaptic plasticity. this is used to explain tolerance to the analgesic properties of opiates though.
 
chainer3k said:
Yes, DXM can help keep opiate tolerance steady, but reducing it, not so much. With cannabis, they do not act on the receptors.

When I was given my first bottle of oxymorphone pills, my doctor prescribed DXM as well to help reduce the speed of tolerance build up.
Click to expand...

for the oxymorphone, did you notice a reduction in analgesic tolerance alone, or reduced tolerance for recreational value as well? from what i have been reading, it looks like DXM is acting mostly at the spinal cord to prevent opiate induced hyperalgesia. it seems like tolerance to the euphoric effects might still develop.
 
Eat a ripe mango an hour before you eat. It is a proven fact that the chemical Mycrene (found only in RIPE Mangos) allows THC to pass the blood brain barrier easier making your high more intense and essentially stronger and better.
 
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